Anti-inflammatory activity part of boat-fruited scaphium seed and preparation method of anti-inflammatory activity part

An active site, fat sea technology, applied in the field of anti-inflammatory active sites, can solve problems such as insignificant anti-inflammatory activity

Inactive Publication Date: 2013-01-09
BEIJING HUAMIAO TRADITIONAL CHINESE MEDICINE ENG TECH DEV CENT
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has been reported that the anti-inflammatory active ingredients of Panda Dahai are mainly polysaccharides, but the anti-inflammatory activity of polysaccharides is not obvious when taken orally or topically (Du Lijun, et al. Chinese Materia Medica, 1995, 18(8): 409-410; Chen Jianmin , et al. Chinese Medicinal Materials, 1994, 17(8): 32-34)

Method used

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  • Anti-inflammatory activity part of boat-fruited scaphium seed and preparation method of anti-inflammatory activity part
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  • Anti-inflammatory activity part of boat-fruited scaphium seed and preparation method of anti-inflammatory activity part

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Experimental program
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Embodiment

[0008] 1. Preparation of the anti-inflammatory active fraction of Panda Dahai

[0009] Panghaihai 2.7kg, crushed and passed through a 10-mesh sieve. The coarse powder was heated and refluxed three times with 4 times the amount of 95% ethanol for 2 hours, 2 hours and 1 hour respectively. The extract was concentrated under reduced pressure to obtain 3240 g of alcohol extract. Take 300 g of the extract, suspend it with 300 ml of methanol, and extract the suspension with an equal volume of cyclohexane. After cyclohexane extraction was complete, the methanol layer was recovered under reduced pressure until no methanol remained. Suspend with 200ml of distilled water, and extract with ethyl acetate and n-butanol in the same amount as the aqueous solution. After recovering each part of solvent, 98.0 g of cyclohexane extract, 12.7 g of ethyl acetate extract, 28.8 g of n-butanol extract and 131 g of extracted water-soluble fraction were obtained. The extracted water-soluble part is ...

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Abstract

The invention relates to an anti-inflammatory activity part discovered in boat-fruited scaphium seed extract and a preparation method of the anti-inflammatory activity part. The preparation method includes: sequentially extracting boat-fruited scaphium seed extract with cyclohexane, ethyl acetate and n-butyl alcohol, and partially drying the extracted water solution to obtain the anti-inflammatory activity part. Anti-inflammatory activity test of mice ear swelling model caused by dimethylbenzene and celiac seepage model caused by acetic acid shows that the part has evident anti-inflammatory activity.

Description

field of invention [0001] The invention relates to an anti-inflammatory active part discovered from the ethanol extract of the traditional Chinese medicine Panda Dahai and a method for preparing the active part. Background technique [0002] Panghaihai, also known as Dadongguo, is the dry and mature seed of Sterculia lychnophora Hance, a plant of the genus Sterculia in the family Sycamore family. The main producing areas are located in Vietnam, Thailand, Malaysia, India and other countries. At present, there are introduced species in southern China, but most of the medicinal materials used in my country are imported from the above-mentioned countries. Traditional Chinese medicine believes that Panda Dahai has the effects of clearing heat and moistening lungs, relieving throat and detoxification, moistening intestines and defecating. Its main pharmacological effects are anti-inflammatory, antibacterial, antiviral, etc. (Du Lijun, et al. Chinese Materia Medica, 1995, 18 (8): ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P29/00A61K131/00
Inventor 王如峰袁铭
Owner BEIJING HUAMIAO TRADITIONAL CHINESE MEDICINE ENG TECH DEV CENT
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