Constructing method and application of zebra fish bacterial infection model

A technology of bacterial infection and construction method, applied in application, fish farming, climate change adaptation, etc., can solve problems such as differences in physiological structure and physiological functions, poor prediction reliability and comparability, and large differences in biological levels, etc., to achieve repeatability Stable and reliable performance, simple experimental process operation, high success rate effect
CN102907356AActive Publication Date: 2013-02-06南京新环检测科技有限公司 +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
南京新环检测科技有限公司
Publication Date
2013-02-06

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Abstract

The invention relates to a constructing method of a zebra fish bacterial infection model and application of the animal model to bacterial infection research and antibiotic screening. The constructing method of the zebra fish bacterial infection model mainly includes the steps of zebra fish selection, bacterium injection, image analysis and / or microwell plate analysis and statistical analysis. The constructing method has the advantages of simplicity, convenience, rapidity, economy, high efficiency, high throughput and the like, and the model can be used for bacterial infection research and antibiotic screening. The constructing method and application of the zebra fish bacterial infection model are of great significance to acceleration of research and development on antibiotics and improvement on treatment of patients suffering from bacterial infection.
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Description

technical field

[0001] The invention belongs to the field of biological model construction, and in particular relates to a construction method and application of a zebrafish bacterial infection model. Background technique

[0002] Bacteria resistance is a thorny problem in the control and treatment of bacteria, and bacteria resistant to antibiotics is becoming a growing threat and becoming more and more common. The overuse of antibiotics has led to multi-drug resistance of bacteria, which makes humans face the danger of "super bacteria infection" [1]. Escherichia coli is the gram-negative bacteria most likely to develop drug resistance. The enterohaemorrhagic Escherichia coli (EHEC) epidemic that broke out in Germany in May 2011 was caused by a type of enterohaemorrhagic Escherichia coli (EHEC) called "husec41". (EHEC) variants that are resistant to many antibiotics. The abuse of antibiotics in animal husbandry has also led to a certain amount of antibiotic resistance of E...

Claims

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