Preparation method of water-soluble isofraxidin mixed powder

A technology of isoxapidine and mixed powder, which is applied in the field of preparation of water-soluble isoxapidine mixed powder, can solve the problems that isoxapidine is difficult to dissolve in water, easily cause allergic reactions, and has poor water solubility, and achieves The effect of high utilization efficiency, good fluidity and low production cost for oral administration

Inactive Publication Date: 2013-02-13
NORTHEAST FORESTRY UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, isoxazinidine is insoluble in water, so it is not convenient to be directly used in clinical practice.
Its fat solubility is high, water solubility is poor, side effects are large, and it is easy to cause allergic reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] First configure 50mg / ml of isoxapyridine solution, and then slowly release the isoxapyridine solution into the homogenized mannitol aqueous solution whose rotation speed is 5000 rpm, the ratio of mannitol to water is 20mg / ml; at 20°C range mix. Homogenize the mixed liquid to make it into a uniform emulsion, remove the organic solvent by drying at 70°C, and obtain a powder with a uniform particle size of not more than 1000 microns by negative pressure freeze-drying.

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Abstract

The invention discloses a preparation method of water-soluble isofraxidin mixed powder, which is characterized in that isofraxidin is dissolved in organic solvent in appropriate proportion to get isofraxidin solution, then the isofraxidin solution is slowly infused into mannitol aqueous solution in the process of homogenization, which is 3-15 times in volume of the isofraxidin solution, the mixed liquid is homogenized to homogeneous emulsion by a homogenizer with the rotational speed of 5,000-20,000 revolutions per minute at the temperature of 4-40 DEG C, the organic solvent is removed at the temperature of 30-100 DEG C, and epigranular and fine nano-powder is obtained through lyophilization. The isofraxidin mixed powder obtained through the preparation method is homogeneous, water-soluble, high-yield, cost-efficient and easy to be industrialized.

Description

technical field [0001] The invention relates to a preparation method of a water-soluble isoxapidine mixed powder, in particular to a preparation method of an anti-fatigue medicine isoxapidine water-soluble ultrafine powder. technical background [0002] Acanthopanax is the dried root and rhizome of Acanthopanax senticosus (Rupr.et Maxim.) Harms, a plant of the family Araliaceae. Kidney yang deficiency, physical weakness, loss of appetite, sore waist and knees, and frequent insomnia. Extracted and processed, it has the functions of calming liver and kidney, benefiting essence and strengthening bones, and is mainly used clinically to treat various cardiovascular diseases. [0003] Isoxiridine is the material basis for the sedative and hypnotic properties of Acanthopanax senticosus. Clinical experiments have shown that isoxazinidine has a good anti-fatigue effect. [0004] However, isoxazinidine is insoluble in water and is not convenient for direct clinical use. Its fat so...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/37A61P29/00A61P39/00
Inventor 祖元刚张晓楠李庆勇祖柏实杨磊赵修华赵春建张宝友孙志强张军
Owner NORTHEAST FORESTRY UNIVERSITY
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