Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors

An intratracheal, low-temperature technology, which is applied in the direction of heating appliances for treatment, cooling appliances for treatment, contraceptives, etc., can solve the problems of limited cooling range and inability to effectively reduce thermal ischemia damage, and reduce heat exchange. coefficient, against warm-ischemic injury of the donor lung, and to reduce the effect of warm-ischemic injury

Active Publication Date: 2013-02-20
SHANGHAI PULMONARY HOSPITAL AFFILIATED TO TONGJI UNIV +1
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Problems solved by technology

[0004] Therefore, the non-invasive application of endotracheal ventilation combined with low temperature for NHBD donor lung protection has attracted the attention of scholars, but previous studies have found that the cooling range of low temperature gas blown into the trachea is extremely limited and cannot effectively reduce warm ischemic injury

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  • Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors
  • Noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors

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Embodiment Construction

[0019] In the present invention, high-flow gas is rapidly cooled into low-temperature gas, which is directly sent into the lungs through the trachea; at the same time, a small amount of lung-preserving liquid is delivered into the lungs together with the cooling gas in a pulsed manner. This not only enhances the heat exchange coefficient in the lung, weakens the uneven specific heat between lung tissue and gas, but also protects the biological activity of tissue cells in the lung. The invention can quickly cool down the NHBD donor lung in situ under the premise of non-invasive operation, reduce warm ischemia injury, and improve the quality of the NHBD donor lung.

[0020] The embodiments of the present invention will be described in detail below with reference to the drawings. Figure 1 is a schematic diagram of the system principle of the device of the present invention.

[0021] The high-pressure gas source provides high-flow gas, which is quickly cooled by the second semico...

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Abstract

The invention belongs to the technical field of auxiliary medical devices, and specifically relates to a noninvasive endotracheal cooling device applied to preservation of lungs from non-heart-beating donors. The device comprises two solenoid valves, a minitype membrane pump, two semiconductor refrigeration modules, a lung preserving fluid tank, a cooling water tank, a radiating coil tube, a fan, a water temperature controller and a water pump, and is divided into three systems, namely a low temperature aerating system, a low temperature lung preserving fluid supply system and a radiating system, wherein the low temperature aerating system carries out low temperature aeration in tracheae, the low temperature lung preserving fluid supply system supplies low temperature lung preserving fluid in the tracheae, and the radiating system carries out circulatory radiating on the two refrigeration modules. The noninvasive endotracheal cooling device can provide low temperature air with high flow capacity under the precondition of noninvasive operation, simultaneously feed high pressure low temperature lung preserving fluid into the tracheae, reduce the heat exchange coefficient, weaken unevenness of specific heat, quickly lower the temperature in the tracheae and the temperature of lungs, alleviate warm ischemia injury and improve the quality of donor lungs.

Description

technical field [0001] The invention belongs to the technical field of auxiliary medical devices, and specifically relates to an intratracheal cooling device applied to lung transplantation and lung preservation of a heartless donor, especially a non-invasive tracheal device that can be provided before the donor confirms and authorizes a thoracotomy for lung extraction. Internal cooling device. Background technique [0002] The only effective treatment for end-stage lung disease is a lung transplant. At present, the number of clinical lung transplantation operations has increased little and has stagnated. The main reason is that there is a severe shortage of brain-dead donors (heart heating donors, HBD). , NHBD) research. However, HBD has a beating heart for blood supply, while NHBD donors, on the contrary, have no heart blood supply, have varying degrees of warm ischemic injury, and gradually lose their function over time, making them unsuitable for lung transplantation. ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/12
Inventor 赵晓刚胥义姜格宁
Owner SHANGHAI PULMONARY HOSPITAL AFFILIATED TO TONGJI UNIV
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