15 results about "Lung protection" patented technology

The invention relates to the technical field of medical prediction, in particular to a digital twinborn prediction method for patient lung protective ventilation supported by ECMO, which comprises the following steps: extracting flow velocity change and jump points under the support of ECMO, constructing a ventilation fluctuation trend map, identifying fluctuation sections by combining compliance and pressure value ratio, delimiting lung partitions and analyzing oxygenation ratio trend. And generating an oxygenation capability classification graph, sequencing ventilation path effects, and outputting a pulmonary protective ventilation digital twinborn prediction scheme. According to the method, dynamic response mapping of ventilation behaviors is established on the basis of timing sequence changes of breathing flow velocity jump characteristics and compliance pressure value ratios, the lung regional ventilation state is accurately recognized, lung function zoning division is achieved by combining oxygenation ratio waveform classification, ventilation path utility sorting is completed through oxygenation descending characteristics under path coverage, and the lung function evaluation accuracy is improved. And a path state prediction sequence is constructed by fusing the change relationship between the tensile stress and the ventilation pressure, so that the dynamic adaptability of the ventilation strategy to the lung mechanics and oxygenation state and the region matching precision are improved.

To provide an apparatus and a method for convertible volume and pressure-controlled lung-protective ventilation.SOLUTION: There is provided a system for actuating a volume and / or pressure-controlled manual ventilator including the manual ventilator, a storage case, and an actuating mechanism. The manual ventilator includes a compressible body, an output one-way valve at an output end, and an input one-way valve at an input end. The storage case includes an inner housing surface configured to accommodate the manual ventilator. The actuating mechanism includes a power unit mechanically coupled to a linear rod mechanism and one or more applicator pads mechanically coupled to the linear rod mechanism and proximal to the compressible body. The linear rod mechanism is configured to convert a rotating motion of the power unit into an axial movement of the linear rod mechanism. The actuating mechanism is configured to apply pressure to the compressible body of the manual ventilator via the one or more applicator pads such that a volume of the compressible body is deflated.SELECTED DRAWING: Figure 1

The invention discloses an acute pneumonia inhibitory ginsenoside Rb1 monomer and application thereof, and relates to the technical field of biological medicines. The ginsenoside Rb1 is screened from a natural product library through a high-throughput screening method, and the ginsenoside Rb1 plays a role in inhibiting expression of inflammatory factors mediated by a menin / SETD2 compound. The monomer can be applied to preparation of anti-inflammatory drugs, anti-tumor drugs, radiotherapy and chemotherapy adjuvant therapy drugs, anti-cytokine storm syndrome (CSS) drugs, lung protection drugs and the like. The compound is applied to drugs for treating acute pneumonia related to inflammatory factor over-activation induced by microbial infection and physical and chemical factors, including inhibition of inflammatory factor expression, reduction of lung tissue inflammatory cell infiltration and pulmonary alveolar protein deposition and the like. The monomer can also effectively inhibit release of lung epithelial cell inflammatory factors induced by ionizing radiation and chemotherapeutic drug exposure. The compound has the advantages of definite action target, high efficiency, specificity, remarkable curative effect, low toxicity and the like.

The invention discloses chest surgery lung protection equipment which comprises a neck sleeve, two connecting ropes are connected to the outer side of the neck sleeve, a hard rod is installed at one end of each connecting rope, a protection plate is slidably installed on the outer sides of the two connecting ropes, two grooves are formed in one side of the protection plate, and pressing assemblies used for pressing the connecting ropes are arranged in inner cavities of the grooves. Elastic blocks are installed on the two sides of the protection plate, an attaching belt is connected between the two elastic blocks, a plurality of connecting strips are connected to the middle of one side of the attaching belt, a pull rope is connected to one ends of the connecting strips, a mounting groove is formed in the middle of the protection plate, and an adjusting assembly used for driving the pull rope to move is arranged in an inner cavity of the mounting groove. The binding belt can be detached by detaching the threaded assembly, so that the number of the protective plates on the outer side of the connecting rope is conveniently changed, the positions of the protective plates can be conveniently changed through the pressing assembly, and the protective plates are adjusted according to the size and position of a wound of a patient.

The utility model relates to the technical field of lung protection devices, in particular to a clinical lung protection device which comprises a chest piece, a front protection plate, a back piece, shoulder straps, axilla straps, a rear protection plate and air holes. The front part of the chest piece is wrapped with a front protection plate, and the back part of the chest piece is connected with a back piece through shoulder straps and axilla straps; the shoulder straps are sewn on the two sides of the upper part of the back piece and are bonded with the two sides of the upper part of the chest piece through magic tapes; the axilla belts are sewn on the two sides of the lower portion of the chest piece and bonded to the two sides of the lower portion of the back piece through hook-and-loop fasteners; the rear protection plate is wrapped in the back piece; and a plurality of air holes are uniformly distributed on the chest piece and the back piece respectively. Through the improvement on the structure, the lung safety protection device has the advantages that the lung safety protection effect is perfect, the wearing comfort is good, and the lung safety protection device has practical performance and practical value, so that the problems and defects in the prior art and equipment are effectively solved.

The present invention relates to the field of medical technology, and specifically to the use of a β-methyl derivative of genipin, Gen‑17, in the preparation of a drug for preventing or treating acute severe pneumonia. The present invention simulates human acute severe pneumonia for the first time with an acute lung injury mouse model, and systematically evaluates the preventive and therapeutic effects of a β-methyl derivative of genipin, Gen‑17, on mice with acute lung injury. The results show that: the β-methyl derivative of genipin, Gen‑17, can significantly reduce the pathological morphological damage of the lung tissue of ALI mice induced by LPS, and inhibit the inflammatory response and oxidative stress of the lung tissue; the protective mechanism of Gen‑17 on the lungs of ALI mice is: it exerts an anti-inflammatory effect by inhibiting the NF‑κB and MAPK signaling pathways, and exerts an antioxidant effect by activating the Keap1 / Nrf2 / HO‑1 signaling pathway. The present application can provide a certain experimental basis for the use of Gen‑17 in the prevention and treatment of acute severe pneumonia.

The invention discloses a lung protection function exosome based on resveratrol-astragalus membranaceus-ginseng induction, an inhalation preparation and application, and belongs to the technical field of biology. The exosome is obtained by inducing lung fibroblasts by active ingredients containing resveratrol, an astragalus extract and a ginseng extract and then secreting the lung fibroblasts; wherein the content of astragaloside in the astragalus extract is not less than 2.0%, and the total content of ginsenoside Rg1 and Rb1 in the ginseng extract is not less than 5.0%. The invention also provides a dry powder inhalant or an aerosol inhalation solution containing the exosome. The exosome and the preparation thereof play a lung protection role through multiple mechanisms such as inflammation regulation and control, oxidative stress resistance and repair promotion, can be used for preventing and / or treating various lung injury diseases such as acute lung injury and pneumonia, and have the advantages of good biocompatibility and strong targeting property.

The utility model discloses a thoracic surgery clinical lung protection equipment belongs to thoracic surgery technical field, a thoracic surgery clinical lung protection equipment, including fixed part one and setting in hand fixed part one fixed part two, the both sides between fixed part one and fixed part two are fixedly connected with the buckle belt, fixed arm no.

The present application relates to the application of Huangjing polysaccharide in the preparation of products for preventing and / or treating lung injury, and belongs to the technical field of traditional Chinese medicines. The application of Huangjing polysaccharide in the preparation of products for preventing and / or treating lung injury, wherein the products are drugs or health products. The present application is based on the traditional Chinese medicine theory of treating disease before it occurs, comprehensively analyzes the clinical application characteristics of traditional Chinese medicines in treating lung injury, selects yin-nourishing and qi-tonifying traditional Chinese medicines that enter the lung meridian as the research object, and uses the constructed in-vivo lung injury chemical prevention evaluation system to screen different lung protection activities of Huangjing polysaccharide. Experimental research shows that Huangjing polysaccharide can obviously improve lung injury and has a protective effect on the lung, especially for acute lung injury.

The invention discloses a lung protecting device which comprises a base plate, an elastic plate is connected to the bottom of the base plate, and the elastic plate is made of elastic materials and is of an arc-shaped structure so as to be better attached to the natural curve of the thorax of the human body. According to the lung protection device, personalized adjustment can be conducted according to the specific contour of the chest of a patient, the lung protection device is tightly attached to the shape of the thorax of the patient, the more attached and more comfortable supporting effect is provided for the patient, and discomfort and oppression caused by the fact that the device is not attached to the body are reduced. The personalized adaptation function ensures the comfort and stability of the device in the wearing process.

The invention belongs to the technical field of biological medicine, and particularly relates to application of a short peptide entrapped by lung-targeted liposome and used for blocking combination of PKM2-FOXO3A in preparation of a medicine for treating stroke-related lung injury, the amino acid sequence of the short peptide is shown as SEQ ID NO.1, the SEQ ID NO.1 RKGEDREGKR and Pe (at) P-Lipo can be used for remarkably relieving MCAO mouse lung tissue pathological injury, and can be used for preparing a medicine for treating stroke-related lung injury. According to the present invention, with the application of the cerebral ischemia injury in the lung, the total reactive oxygen species (ROS) level in the lung tissue and the mitochondrial ROS level, the reduction of the ATP content can be reversed, the level of the lung tissue inflammation-related protein can be reduced, and the enrichment of PKM2, FOXO3A and TXNIP in the mitochondria can be reduced so as to alleviate the lung tissue oxidative stress and the mitochondrial injury caused by the cerebral ischemia injury, and provide the lung protection effect;

The invention relates to the field of medicines, in particular to application of Noregenin to treatment of acute lung injury or acute respiratory distress syndrome. According to the application disclosed by the invention, NLRP3 inflammasome activation and downstream inflammatory factor release are remarkably reduced by utilizing an inhibition effect of Noregenin on Nur77, so that lung inflammatory response, macrophage proinflammatory polarization and tissue damage in acute lung injury and acute respiratory distress syndrome are effectively relieved; and the pharmaceutical composition shows a definite lung protection effect in various dosage forms and administration modes.

The utility model discloses a calibration device of a portable breathing machine, which belongs to the technical field of medical instruments and comprises a breathing machine body, a three-way pipeline is arranged on one side of the breathing machine body, a calibration component is arranged outside the three-way pipeline and comprises a second knob, an air pipe is arranged in the three-way pipeline, and a first knob is arranged on the air pipe. The other end of the air pipe is connected with an artificial simulation lung in a clamped mode, and a protection box is arranged on one side of the breathing machine body. Through the arrangement of the second knob, the air pipe, the artificial simulation lung, the protection box and the external oxygen pipe, when calibration is needed, the second knob is turned on, the artificial simulation lung can simulate oxygen uptake through the air pipe, the current tidal volume of oxygen can be tested, and data are displayed on the control panel; the pressure of the breathing machine is controlled through the displayed data, so that a user can automatically calibrate the breathing machine more conveniently, and when the oxygen amount is insufficient, oxygen can be supplied through an external oxygen pipe, and an oxygen bottle does not need to be replaced.

The invention relates to the technical field of biological medicine, in particular to application of procyanidine B2 in preparation of a product for relieving animal lung injury caused by chronic cold exposure. The procyanidine B2 is found to be capable of relieving oxidative stress injury of the lung and enhancing the oxidation resistance of the lung. Technical support is provided for application of procyanidine B2 as a natural lung protection medicine under the condition of chronic cold exposure of animals, and a new thought is provided for comprehensive treatment of animal lung injury caused by chronic cold exposure.