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Application of usnic acid and/or salts thereof

A kind of technology of usnic acid and usage, applied in the direction of soap detergent and other compounding agents, skin care preparations, chemical instruments and methods, etc., can solve the problems of surrounding tissue damage, hair follicle wall structure damage, hair follicle integrity damage, etc. For simplicity of application and ease of use

Inactive Publication Date: 2013-03-06
LB COSMECEUTICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0017] (5) Propionibacterium acnes can secrete a large amount of esterase and protease, thus causing damage to the structure of the hair follicle wall
[0019] (7) The lack of linoleic acid substances causes the generation of free radicals, O 2 、H 2 o 2 and OH · causing damage to the surrounding tissue and disruption of the integrity of the hair follicle

Method used

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  • Application of usnic acid and/or salts thereof
  • Application of usnic acid and/or salts thereof
  • Application of usnic acid and/or salts thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 The inhibitory experiment of usnic acid to Propionibacterium acnes

[0043] Experimental strain: Propionibacterium acnes (ATCC6919)

[0044] Medium:

[0045] (1) Liquid medium: tryptone 10g / L, beef extract 10g / L, glucose 5g / L, NaCl 5g / L, yeast extract 3g / L, sodium acetate 3g / L, soluble starch 1g / L, cysteine Hydrochloride 0.5g / L, dissolved in distilled water, adjusted to pH 6.8±0.2, autoclaved at 115°C for 20min. (2) Solid medium: add agar 15g / L on the basis of liquid medium.

[0046] Experimental method: Determination of inhibition zone

[0047] Propionibacterium acnes was inoculated in solid medium, and activated under anaerobic conditions at 37°C for 2 days. After activation, the plaque was directly diluted with physiological saline to prepare a bacterial suspension. Take 0.5ml of the activated bacterial suspension in liquid medium, and culture it under anaerobic conditions at 37°C for 2 days, which is the experimental bacterial suspension. The experime...

Embodiment 2

[0054] Example 2 Sodium Usnicate Inhibits Propionibacterium acnes MIC Value Determination

[0055] Experimental strain: Propionibacterium acnes (ATCC6919)

[0056] Medium: (1) Liquid medium: tryptone 10g / L, beef extract 10g / L, glucose 5g / L, NaCl 5g / L, yeast extract 3g / L, sodium acetate 3g / L, soluble starch 1g / L, Cysteine ​​hydrochloride 0.5g / L, dissolved in distilled water, adjusted to pH 6.8±0.2, autoclaved at 115°C for 20min.

[0057] (2) Solid medium: add agar 15g / L on the basis of liquid medium.

[0058] Experimental method: Determination of the minimum inhibitory concentration (MIC value) of traditional Chinese medicine extracts

[0059] Propionibacterium acnes was inoculated in solid medium, and activated under anaerobic conditions at 37°C for 2 days. After activation, the plaque was directly diluted with physiological saline to prepare a bacterial suspension, and the bacterial suspension was diluted with liquid medium. The final bacterial concentration was 10 5 CFU / ...

Embodiment 3

[0066] Example 3 Usnea extract inhibits Propionibacterium acnes MIC value determination

[0067] Experimental strain: Propionibacterium acnes (ATCC6919)

[0068] Medium: (1) Liquid medium: tryptone 10g / L, beef extract 10g / L, glucose 5g / L, NaCl 5g / L, yeast extract 3g / L, sodium acetate 3g / L, soluble starch 1g / L, Cysteine ​​hydrochloride 0.5g / L, dissolved in distilled water, adjusted to pH 6.8±0.2, autoclaved at 115°C for 20min.

[0069] (2) Solid medium: add agar 15g / L on the basis of liquid medium.

[0070] Experimental method: Determination of minimum inhibitory concentration (MIC value) of Usnea extract

[0071] The Usnea extract was purchased from Xi'an Sinuote Biotechnology Co., Ltd., and the plant extract was derived from Usnea aspiratus.

[0072] Propionibacterium acnes was inoculated in solid medium, and activated under anaerobic conditions at 37°C for 2 days. After activation, the plaque was directly diluted with physiological saline to prepare a bacterial suspension...

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Abstract

The invention discloses an application of usnic acid and / or salts thereof as a propionibacterium acnes inhibitor. The invention further discloses an application of usnic acid and / or salts thereof in preparation of drugs or cosmetics for preventing or treating pimples caused by the breeding of the propionibacterium acnes. The invention can effectively treat the pimple generation caused by the breeding of the propionibacterium acnes. The usnic acid and / or salts thereof are from both the sunglow plants and the artificial synthesis, have the advantages of low toxicity for the human body and high bacteriostatic action for the propionibacterium acnes, can be prepared into various external medicine dosage forms and cosmetics and have good application prospects.

Description

technical field [0001] The present invention relates to the use of a compound, in particular to the use of usnic acid and / or its salt in the preparation of Propionibacterium acnes inhibitors, and to the use of usnic acid and / or its salt in the preparation of acne Use in medicine or skin care products for acne caused by Propionibacterium multiplication. Background technique [0002] Usnenic acid is the dried lichen extract of Usnea diffracta Vain. and Usnea longissima Ach. of Usneaceae (Usneaceae) plants. Usnic acid is also called lichenic acid, the English name is: Usninic acid; Molecular formula: C 18 h 16 o 7 ; Chemical name: 1,3(2H, 9bH)-Dibenzofurandione, 2,6-diaacetyl-7, 9-dihydroxy-8, 9b-dimethyl; Molecular weight: 344.1. Physicochemical properties: Usnicic acid has optical activity and is found in two forms (+)- and (-)- in lichens. Usnic acid is easily soluble in chloroform, but insoluble in methanol. In the color reaction of lichen, usnic acid reacts with KOH ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/49A61K31/343A61Q19/00A61Q19/10A61P17/10A61P31/04C11D9/50C11D9/26
Inventor 孙常磊段朝辉朱丽平翟春涛
Owner LB COSMECEUTICAL TECH CO LTD
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