34 results about "Lichen acid" patented technology

The invention relates to a Chinese herbal medicinal bactericide, which aims to solve the problem of public hazards of the conventional bactericide. The bactericide comprises the following Chinese herbal medicines in part by weight: 40 to 120 parts of sessile stemona root, 40 to 120 parts of camphor tree, 35 to 105 parts of pomegranate rind, 35 to 105 parts of macleaya cordata, 35 to 105 parts of common andrographis herb, 35 to 105 parts of isatis root, 30 to 90 parts of barberry root, 30 to 90 parts of vietnamese sophora root, 30 to 90 parts of common fibraurea stem, 30 to 90 parts of densefruit pittany root-bark, 30 to 90 parts of officinal magnolia bark, 30 to 90 parts of common threewingnut root, 25 to 75 parts of akebia stem, 25 to 75 parts of oriental variegated coralbean bark, 25 to75 parts of fourstamen stephania root and 25 to 75 parts of humifuse euphorbia herb. The bactericide is prepared by the following steps of: performing ethanol precipitation on the Chinese herbal medicines to obtain the original liquid medicine; diluting sodium usnic acid by using a solvent; and adding 0.1 to 0.3 weight percent of diluted sodium usnic acid into the original liquid medicine. The finished Chinese herbal medicinal bactericide comprises 0.3 percent of stemonine, is brownish red, has the pH value of 7 to 8 and the density of 1.10g / cm<3>, and has the advantages of capability of effective sterilization and no damage to humans.

The invention relates to a Chinese herbal medicinal insecticide, and aims to solve the problem of public hazards of the conventional insecticide. The Chinese herbal medicinal insecticide comprises the following Chinese herbal medicines in part by weight: 50 to 110 parts of macleaya cordata, 50 to 110 parts of eucalyptus robusta smith, 40 to 100 parts of betel nut, 40 to 100 parts of pumpkin seed,40 to 100 parts of clematis root, 40 to 100 parts of celastrus angulatus, 30 to 90 parts of stone-like omphalia, 30 to 90 parts of grand torreya seed, 30 to 90 parts of camphor tree, 30 to 90 parts of pomegranate rind, 30 to 90 parts of lightyellow sophora root, 30 to 90 parts of rhododendron molle, 30 to 70 parts of fourstamen stephania root, 30 to 70 parts of sessile stemona root, 30 to 70 parts of hindu datura flower and 30 to 70 parts of liquoric root. The Chinese herbal medicinal insecticide is prepared by the following steps of: performing alcohol precipitation on the Chinese herbal medicines to obtain the original liquid medicine; diluting sodium usnic acid by using a solvent; and adding 0.1 to 0.3 weight percent of diluted sodium usnic acid into the original liquid medicine. The finished Chinese herbal medicinal insecticide comprises 0.5 percent (g / ml) of sanguinarine, is brownish red, has the ph value of 7 to 8 and the density of 1.10g / cm<3>, and has the advantages of effective insecticidal capability, no damage to humans, high adsorbability and durable seepage force.

The invention relates to an in-vehicle air freshener with a sterilization function. The in-vehicle air freshener is prepared from raw materials in parts by weight as follows: 104-124 parts of wormwood, 104-124 parts of camellia chrysantha, 104-124 parts of honeysuckle flowers, 83-103 parts of Chinese atractylodes, 83-103 parts of usnic acid, 76-98 parts of Chinese mugwort, 76-98 parts of sweet wormwood herbs, 55-80 parts of tea tree oil, 55-80 parts of eucalyptus oil, 89-110 parts of a Hang Zhou chrysanthemum flower extract, 76-98 parts of shaddock peels, 55-80 parts of sweet orange oil, 50-65 parts of essential oil, 50-65 parts of plant essence, 55-70 parts of ethanol and 40-55 parts of deionized water. The invention further discloses a preparation method of the in-vehicle air freshener. The in-vehicle air freshener has remarkable bacteriostasis and antibacterial effects, is lasting in bacteriostasis time, smells pleasant, really realizes air purification, has no irritation to skin and the respiratory tract, is safe and stable, doesn't contain a surfactant and doesn't affect the environment.

The invention provides a compound formula with whitening and anti-aging effects and application thereof. The formula is formed by compounding plant extract, vitamin and biochemical preparation. The plant extract consists of one or more of herbal plants of pine extract, vitamin A, vitamin E, rhodiola rosea extract, lily extract, dipotassium glycyrrhizate, hyaluronic acid, azelaic acid, propolis, grape seed, seaweed, phytic acid, green tea, sea-buckthorn, usnic acid, abietic acid, vitamin C, vitamin B, vitamin E, maltose, maltitol, glucose, glucitol, glucan, trehalose, glycyrrhizinic acid and the like; and proved by a large amount of clinical tests, the formula has good whitening and anti-aging effects on the skin. The formula can be prepared into cosmetics such as cleaning products, maintenance products, beautifying products and the like according to the conventional processes and accessories for preparing the cosmetics.

The invention relates to compound medicine toothpaste. An abradant, a wetting agent and deionized water are taken as the main components, and a composition of tranexamic acid, organic acid zinc, usnic acid and / or usnic acid salt is at least added. According to the compound medicine toothpaste, by adopting the mode of combined usage of the tranexamic acid, the usnic acid and / or usnic acid salt and zinc ions, the toothpaste has the very high hemostasis, anti-bacterium and anti-inflammation functions, gingival bleeding can be quickly prevented, and the symptoms such as red and swollen gums, oral ulcer and dental plaque are effectively relieved; meanwhile, introduced magnolol can generate the synergistic effect with the formula, and then the anti-bacterium and hemostasis effects of the toothpaste are further improved.

The invention discloses a production technology for extracting usnic acid from usnea longissima. The technology comprises the steps that a raw material is subjected to coarse grinding, and fed in from a feeding hopper; an extraction tank unit host rotates to slowly push the material from the front end of a unit backwards; an extraction solvent enters an extraction tank from a liquid inlet tube at the tail end of the unit, passes through the moving material from the back end of the tank, and flows towards the front end; and solid and liquid substances are contacted fully in an inverse motion, so that effective components in the medicinal material are extracted. Dregs are forcibly pushed to a dreg discharge port by a discharge transport and then discharged; a special juice squeezer squeezes the dregs; residual medicine liquor in the dregs is squeezed out of a medicinal material tissue; and the content of the residual medicine liquor in the dregs is reduced. The extraction efficiency is higher, and the extraction is more complete. The method adopts a continuous extraction tank unit for extraction, and is combined with a silica gel column chromatography for purification, so that a separating effect is better. Finished usnic acid with a maximum yield of 1% and the content above 95% can be obtained.

This invention relates to a process for extracting usnic acid from Usnea longissima. The process comprises: adding dried Usnea longissima in a percolator, adding 3-5 volume times of ethyl acetate, heating to 60-80 deg.C, extracting, concentrating, freezing for crystallization, filtering, recrystallizing to obtain 90-95% usnic acid, dissolving in chloroform to remove insoluble impurities, and crystallizing to obtain higher than 98% usnic acid. The method has such advantages as high extraction rate (higher than 85%), high usnic acid utility, saved biological resources, simple process, low energy consumption and is suitable for mass production.

The invention discloses a method for extracting volatile oil from usnea and simultaneously extracting usnea polysaccharide and usnic acid. The method for extracting volatile oil from usnea includes the following steps: (1) reflux extraction: crushing dried usnea, adding an organic solvent, reflux extracting, and filtering to obtain an extracting solution; (2) column chromatography separation: arranging a chromatography column filled with a filler on the extracting solution obtained in the step (1), collecting an effluent liquid, and concentrating to obtain the volatile oil. The invention further discloses a method for simultaneously extracting usnea polysaccharide and usnea acid. In the volatile oil, usnea polysaccharide and usnea acid products obtained by the method, the mass content of the volatile oil, usnea polysaccharide and usnea acid can reach 95.2%, 97.5% and 99.7% respectively, and the yield can reach 95%, 95% and 97% respectively. The method can comprehensively utilize usnearesources, has high product yield, high purity, simple process, strong operability, low cost and little pollution, so that the method is suitable for industrial production.

The invention relates to a method for extracting usnic acid from sun-lo, which comprises the following steps: pulverizing sun-lo, adding alkaline alcohol solution, carrying out reflux extraction for 2-3 times, recycling ethanol from the extracting solution, adsorbing by adding to cationic resin macroporous resin series columns, eluting with 50-90% ethanol, concentrating the eluent until the alcohol crystal concentration reaches 30-50%, and refluxing anhydrous ethanol to recrystallize. The method for producing usnic acid can reduce the pollution and lower the production cost. The invention is suitable for industrial production.

The present invention is ultrasonic usnic acid extracting process. Cut usnea is added with 75-98 % concentration alcohol solution in 2-6 times, and ultrasonically extracted at the frequency of 30-50 KHz for 10-50 min, and through further filtering to obtain filtrate, concentrating while recovering alcohol and vacuum freeze drying, usnic acid is obtained. The present invention has high usnic acid extracting rate, can save usnea resource, and has simple technological process, low power consumption and low cost.

The invention discloses an application of usnic acid and / or salts thereof as a propionibacterium acnes inhibitor. The invention further discloses an application of usnic acid and / or salts thereof in preparation of drugs or cosmetics for preventing or treating pimples caused by the breeding of the propionibacterium acnes. The invention can effectively treat the pimple generation caused by the breeding of the propionibacterium acnes. The usnic acid and / or salts thereof are from both the sunglow plants and the artificial synthesis, have the advantages of low toxicity for the human body and high bacteriostatic action for the propionibacterium acnes, can be prepared into various external medicine dosage forms and cosmetics and have good application prospects.

The invention provides an usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in oral care. The supramolecular complex is prepared from sulfobutyl-beta-cyclodextrin and usnic acid coated with the sulfobutyl-beta-cyclodextrin. The usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex is prepared through a simple method and solves the technical problem of poor solubility of usnic acid. The invention provides an oral care product of the usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex. The formula has good effects of preventing dental caries, ozostomia and dental ulcer.

The invention discloses application of usnic acid (UA) in anti-influenza virus medicaments. The invention shows that the usnic acid has a certain anti-influenza virus function in vitro on MDCK cells and A549 cells infected by influenza A viruses, such as H5N1, H3N2 and the like. The impact effect of the medicaments applying the usnic acid relatively approaches that of a positive control medicament, namely amantadine; in addition, the usnic acid has better inhibiting effect on inflammatory reaction induced by the influenza viruses, which exposes that the medicaments applying the usnic acid have the prospect of being developed into anti-influenza virus medicaments.

Topical skin treatment formulation containing usnic acid or an usnate salt, dissolved in a solvent system comprising (i) dimethyl isosorbide; (ii) a C1 to C9 alkyl salicylate; and (iii) a glyceryl fatty acid ester. The solvent system may also comprise an alcohol, a polyoxyalkylene-based solvent, and / or a C1 to C4 alkyl glucose ester. The formulation may be used in the treatment of microbial conditions, in particular acne. The solvent system assists in the effective dissolution of the usnic acid or usnate and in targeting its delivery to relevant sites on the skin.

The invention discloses a drug for treating cirrhosis with ascites, a preparation method thereof and an application; the drug is prepared from, by weight, 7-15 parts of catechinic acid, 1-5 parts of benzbromarone, 11-19 parts of chitin, 3-7 parts of usnic acid. The drug is prepared by mixing and grinding benzbromarone and chitin; sieving through 120 meshes; adding 3.7 times of deionized water by mass of the both; then raising temperature to 81-83 DEG C, and stirring for 36-39 min under the temperature; preparing a mixture A; placing usnic acid and catechinic acid in a mixture A, then performing ultrasound treatment on the mixture for 28 min at 56 DEG C; stirring the mixture until dry at 61 DEG C, and prilling the mixture. The total effective rate for treating the cirrhosis with ascites is 98% above, and the drug can improve liver function of patients, correct hypoproteinemia and rapidly remove ascites, while reduce complication. The raw materials are simple and easy to acquire, the preparation technique is simple, the production cost is low, the treatment effect is good, and visible effect is quick; the drug is free from toxic and side effects, and applicable to large-scale production and popularization.

The invention provides a compound traditional Chinese medical composition which comprises the following components: active ion calcium, podophyllotoxin extract, lygodium japonicum extract, macleaya cordata extract, oleuropein, polygonum cuspidatum extract, usnic acid, essential oil of chaste tree, organic tea tree essential oil, Eastern Indian sandalwood essential oil, sea salt and medical citric acid. The compound traditional Chinese medical composition provided by the invention has superior curative effect and generalization performance and is used as an external medicine which is directly effected on sebaceous gland and mucosa, and is not harmful to a body, not irritant and not allergic. The compound traditional Chinese medical composition not only has positive energy formula of mineral components, but also maintains unique effect of Chinese herbal medicines, and the compound traditional Chinese medical composition is free from any irritation and harm. The compound traditional Chinese medical composition is a pure natural green therapy for removing secret sorrow.

The invention provides a nano composite sophorae flavescentis preparation and relates to the technical field of traditional Chinese medicines. The nano composite sophorae flavescentis preparation is prepared from the following components in parts by weight: 50-60 parts of sophorae flavescentis, 15-25 parts of usnic acid, 1-10 parts of borneol, 1-10 parts of aloe juice, 5-15 parts of tert butyl alcohol and 1-10 parts of purified water. The sophorae flavescentis washing lotion prepared by the invention has strong antibacterial activity, no irritation and no side effect, is good in long-term prevention curative effect, has efficacy obviously better than that of pure traditional Chinese medicine or western medicine and is an external washing lotion used for vaginal irrigation of women, vulva cleaning of women and men and daily health nursing of women and men, and especially used for gynecological diseases.

The invention relates to a Chinese herbal medicinal preparation for treating advanced lung cancer. The secret recipe of the Chinese herbal medicinal preparation overcomes chemotherapy or excision for treating the lung cancer in particular the advanced lung cancer, and the Chinese herbal medicinal preparation comprises the following components in percentage by weight: 19 to 21 percent of elaeagnus glabra, 29 to 31 percent of gnaphalium affine, 19 to 21 percent of usnea longissima, 19 to 21 percent of cynoglossum, and 9 to 11 percent of Chinese alangium root. The leaf of the elaeagnus glabra contains alkaloid and the like and has the function of relieving asthma by injecting a leaf decoction into the abdominal cavity of a cavy. The gnaphalium affine contains 5 percent of flavonoid glycoside and the like and has the function of relieving cough by drenching a decoction for treating chronic cough. The usnea longissima contains usnic acid to inhibit the activity of a-glycerol phosphate tetrazolium reductase in sugar mitochondria of a rat ascites tumor cell. The cynoglossum contains lasiocarpine which causes parenchyma cells and a huge nucleus in the lung of a rat to have anti-tumor function. The Chinese alangium root contains alkaloid which can cause muscle relaxation so that pain sensation reaction disappears by injecting a decoction into the abdominal cavity of a mouse. In ten cases of clinical treatments, two cases are cured by taking the decoction orally, 6 cases are cured by taking a condensate orally, one case is effective and one case is invalid, the total effective rate is more than 80 percent, and the curative ratio is more than 60 percent.

The present invention provides a Chinese herb disinfection liquid, which comprises, by weight, 15 g of dandelion, 18 g of cnidium monnieri (l.) cuss, 15 g of polygonum cuspidatum, 25 g of andrographis paniculata, 30 g of santonin, 35 g of celastrus angulatus maxim, 20 g of camphor tree, 20 g of stephania tetrandra, and 15 g of rhododendron molle. The preparation method comprises: weighing the bulk drugs according to the weight part ratio, carrying out percolation with 15 times the amount of 65% ethanol at a rate of 1.5 ml / min, taking the percolation liquid, filtering, adding 1 ml of Tween 80 and 1 ml of 0.03% by weight of usnic acid sodium, uniformly mixing, and bottling to obtain the product, wherein the usnic acid sodium is dissolved with a solvent, and the obtained solution is mixed in the raw drug liquid. The prepared Chinese herb disinfection liquid of the present invention has advantages of effective disinfecting and no harm to human body.

An antibacterial or anti-acne formulation suitable for topical or local application to human skin containing (a) either usnic acid or an usnate and (b) a metal salt selected from copper salts, bismuth salts, and mixtures thereof, wherein if the component (a) is an usnate, the components (a) and (b) are not the same compound.

The present invention is ultrasonic usnic acid extracting process. Cut usnea is added with 75-98 % concentration alcohol solution in 2-6 times, and ultrasonically extracted at the frequency of 30-50 KHz for 10-50 min, and through further filtering to obtain filtrate, concentrating while recovering alcohol and vacuum freeze drying, usnic acid is obtained. The present invention has high usnic acid extracting rate, can save usnea resource, and has simple technological process, low power consumption and low cost.

The invention discloses a preparation method of an algae culture fertilizer containing Chinese herbal medicines. The preparation method comprises the steps of crushing the Chinese herbal medicines, adding water, carrying out microwave extraction, filtering, adding an organic solvent into the filtrate, removing the filtrate, concentrating to obtain a Chinese herbal medicine preparation, adding sodium humate, potassium fulvate, bamboo vinegar liquid, microelements and attapulgite, uniformly mixing, granulating, and drying, so as to obtain the algae culture fertilizer, wherein the organic solventfor precipitating the Chinese herbal medicines contains ethanol, sodium usnic acid and sodium butyrate. The preparation method provided by the invention has the advantages that the production energyconsumption is low, particles are rapidly formed, the raw material utilization rate is high, and the production efficiency is high; and prepared algae culture fertilizer particles are high in yield offinished products, good in stability and capable of optimizing the algae phase and rapidly fertilizing and purifying water.

The invention discloses a composition for relieving asthenopia, as well as a preparation method and application thereof. The composition is prepared from the following raw materials by weight percent:7-15 percent of lutein, 1-4 percent of usnic acid, 8-17 percent of saccharomyces cerevisiae extract, 10-18 percent of crithmum maritimum extract, 5-11 percent of bamboo vinegar and the balance of auxiliaries. The composition can be used for effectively relieving asthenopia, is prepared from easily available raw materials, basically does not have toxic or side effect, has an effective rate for treating asthenopia being 96 percent, can be used for improving the visual level of patients with cataract and age-related macular degeneration and improving the visual acuity and central visual field ofpatients with retinal pigment degeneration, and has a high popularization value.

The invention discloses a method for extracting usnic acid from cladonia alpestris. The method comprises the following steps: (1) reflux extraction: smashing dry cladonia alpestris into powder, adding ethyl acetate, carrying out reflux extraction for two to three times at the temperature of 70 to 80 DEG C, filtering, merging a filter liquor, and concentrating to obtain a dry extract; (2) recrystallization: dissolving the dry extract with ethyl acetate at the temperature of 70 to 80 DEG C, after cooling to 25 DEG C, quickly (shorter than 1 h), dissolving out and separating usnic acid coarse grain, and then using ethyl acetate for recrystallization so as to obtain usnic acid crystal. The yield of the extracted and separated product is high, the purity is high, meanwhile few types of solvents are used, special equipment is not needed, the preparation period is short, preparation quantity is large, and the method is applicable for mass production.

The invention aims at providing liquid shampoo containing usnic acid and totaxin. The liquid shampoo is characterized by comprising an usnic acid fatty alcohol polyoxyethylene ether complex, a totaxin fatty alcohol polyoxyethylene ether complex, lauryl glucoside, coconut oil alcohol ethoxylate sulfate triethanolamine salt, coconut oil alcohol amide, coconut oil alkyl dimethyl betaine, a pearling agent, a thickener JR400, a slip agent, a pH modifier, a preservative, a chelating agent, essence and purified water. The usnic acid fatty alcohol polyoxyethylene ether complex and the totaxin fatty alcohol polyoxyethylene ether complex have good efficacies of removing scurf and relieving itching on hair of a human body, simultaneously have the efficacies of promoting qi to activate blood, nourishing hair roots, expanding head blood capillaries, promoting blood circulation of the hair roots, and the like, and are also capable of improving the tensile strength and the extensibility of the hair and keeping the hair elastic and not easy to be snapped. The liquid shampoo is purple pearl thick liquid in appearance, and is free of thrill on human skin, and low in toxicity, and the pH value is 6-7.

The invention discloses a method for producing 4‑O‑demethylbarbalicic acid by using Aspergillus terreus strains to synthesize oakmoss, and relates to the technical fields of new strains, microbial fermentation technology and chemical synthesis. The Aspergillus terreus strains are soil Aspergillus terreus (Aspergillus terreus) MEFC06, fermentation culture of Aspergillus terreus species; separation and purification to obtain 4‑O‑desmethyl barbalicic acid, hydrolysis of 4‑O‑desmethyl barbalic acid to 2,4‑dihydroxy‑ 3,6-dimethylbenzoic acid; using a methylating agent to carry out methylation reaction, after the reaction, treatment can obtain 2,4-dihydroxy-3,6-dimethylbenzoic acid methyl ester (synthetic oakmoss ). A new method for producing synthetic oak moss by combining microbial fermentation and chemical synthesis is provided, which is green and ecological, has short synthetic route, simple process and high yield.

The invention relates to an antibacterial Chinese herbal medicine liquid for spray-coating wounds. The antibacterial Chinese herbal medicine liquid solves the problem that the existing disinfectant has high irritation. Extract of Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with purified water having the weight 7-11 times that of the extract so that a water-soluble raw medicine is obtained, and the water-soluble raw medicine is added with usnic acid sodium salt so that the desired product is obtained; or the extract of the Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with a part of purified water so that a water-soluble raw medicine is obtained and then an usnic acid sodium salt aqueous solution prepared from usnic acid sodium salt and the other part of the purified water is added into the water-soluble raw medicine so that the desired product is obtained, wherein a weight ratio of the extract subjected to alcohol precipitation to the two parts of purified water is 1: 7-11 and a weight ratio of usnic acid sodium salt to the water-soluble raw medicine is 1.5-3: 1000. The Chinese herbal medicines as raw materials comprises, by weight, 50-110 parts of common andrographis herb, 50-110 parts of cortex phellodendri, 40-100 parts of radix berberidis, 40-100 parts of Celastrus angulatus, 40-100 parts of isatis root, 40-100 parts of radix sophorae flavescentis, 40-80 parts of mulberry bark, 40-80 parts of santonin, 40-80 parts of aloe, 40-80 parts of fructus rosae laevigatae, 40-80 parts of akebia stem, 40-80 parts of subprostrate sophora, 30-70 parts of Sichuan red orange peel, 30-70 parts of rheum officinale, 30-70 parts of corydalis tuber and 30-70 parts of licorice root. The antibacterial Chinese herbal medicine liquid has the advantages of small irritation, lasting disinfection effect, short treatment course and use convenience.

The invention belongs to the field of pharmacy, and relates to the new application of usnic acid and its derivatives, in particular to the application of usnic acid and its derivatives in the preparation of medicines for treating skin diseases caused by Malassezia bacteria, especially to the use of usnic acid and its derivatives Use of the compound in the preparation of medicines for treating excessive dandruff, seborrheic dermatitis, atopic dermatitis and psoriasis caused by Malassezia bacteria. The present invention is through inhibition experiment, and result shows, and the average value of inhibition circle is 20mm, shows that usnic acid can obviously suppress the growth of Malassezia; The growth of Malassezia was inhibited when the drug concentration gradient of acid and its derivatives increased. The usnic acid and its derivatives of the present invention can be used to prepare medicines for treating skin diseases caused by Malassezia, and can also be used to prepare daily chemical products and external preparations for preventing and treating the above skin diseases.

The invention provides a compound traditional Chinese medical composition which comprises the following components: active ion calcium, podophyllotoxin extract, lygodium japonicum extract, macleaya cordata extract, oleuropein, polygonum cuspidatum extract, usnic acid, essential oil of chaste tree, organic tea tree essential oil, Eastern Indian sandalwood essential oil, sea salt and medical citric acid. The compound traditional Chinese medical composition provided by the invention has superior curative effect and generalization performance and is used as an external medicine which is directly effected on sebaceous gland and mucosa, and is not harmful to a body, not irritant and not allergic. The compound traditional Chinese medical composition not only has positive energy formula of mineral components, but also maintains unique effect of Chinese herbal medicines, and the compound traditional Chinese medical composition is free from any irritation and harm. The compound traditional Chinese medical composition is a pure natural green therapy for removing secret sorrow.