The invention discloses an application of combination of usnic acid and
azole drugs in preparation of an
antifungal drug and the
antifungal drug, and relates to the technical field of
antifungal drugs, systematic in-vitro
drug sensitive tests find that although the
natural product usnic acid (UA) has limited bacteriostatic activity on various pathogenic fungi, the usnic acid (UA) has limited bacteriostatic activity on various pathogenic fungi; however, when the compound is combined with clinically common
azole drugs (such as ITC, VOR, POS and ISA / FLC), the compound can generate a remarkable synergistic killing effect on a series of clinically separated strains.