34 results about "Lichen acid" patented technology

The invention relates to a Chinese herbal medicinal bactericide, which aims to solve the problem of public hazards of the conventional bactericide. The bactericide comprises the following Chinese herbal medicines in part by weight: 40 to 120 parts of sessile stemona root, 40 to 120 parts of camphor tree, 35 to 105 parts of pomegranate rind, 35 to 105 parts of macleaya cordata, 35 to 105 parts of common andrographis herb, 35 to 105 parts of isatis root, 30 to 90 parts of barberry root, 30 to 90 parts of vietnamese sophora root, 30 to 90 parts of common fibraurea stem, 30 to 90 parts of densefruit pittany root-bark, 30 to 90 parts of officinal magnolia bark, 30 to 90 parts of common threewingnut root, 25 to 75 parts of akebia stem, 25 to 75 parts of oriental variegated coralbean bark, 25 to75 parts of fourstamen stephania root and 25 to 75 parts of humifuse euphorbia herb. The bactericide is prepared by the following steps of: performing ethanol precipitation on the Chinese herbal medicines to obtain the original liquid medicine; diluting sodium usnic acid by using a solvent; and adding 0.1 to 0.3 weight percent of diluted sodium usnic acid into the original liquid medicine. The finished Chinese herbal medicinal bactericide comprises 0.3 percent of stemonine, is brownish red, has the pH value of 7 to 8 and the density of 1.10g / cm<3>, and has the advantages of capability of effective sterilization and no damage to humans.

The invention provides a compound formula with whitening and anti-aging effects and application thereof. The formula is formed by compounding plant extract, vitamin and biochemical preparation. The plant extract consists of one or more of herbal plants of pine extract, vitamin A, vitamin E, rhodiola rosea extract, lily extract, dipotassium glycyrrhizate, hyaluronic acid, azelaic acid, propolis, grape seed, seaweed, phytic acid, green tea, sea-buckthorn, usnic acid, abietic acid, vitamin C, vitamin B, vitamin E, maltose, maltitol, glucose, glucitol, glucan, trehalose, glycyrrhizinic acid and the like; and proved by a large amount of clinical tests, the formula has good whitening and anti-aging effects on the skin. The formula can be prepared into cosmetics such as cleaning products, maintenance products, beautifying products and the like according to the conventional processes and accessories for preparing the cosmetics.

The invention relates to a method for extracting usnic acid from sun-lo, which comprises the following steps: pulverizing sun-lo, adding alkaline alcohol solution, carrying out reflux extraction for 2-3 times, recycling ethanol from the extracting solution, adsorbing by adding to cationic resin macroporous resin series columns, eluting with 50-90% ethanol, concentrating the eluent until the alcohol crystal concentration reaches 30-50%, and refluxing anhydrous ethanol to recrystallize. The method for producing usnic acid can reduce the pollution and lower the production cost. The invention is suitable for industrial production.

The invention discloses an application of usnic acid and / or salts thereof as a propionibacterium acnes inhibitor. The invention further discloses an application of usnic acid and / or salts thereof in preparation of drugs or cosmetics for preventing or treating pimples caused by the breeding of the propionibacterium acnes. The invention can effectively treat the pimple generation caused by the breeding of the propionibacterium acnes. The usnic acid and / or salts thereof are from both the sunglow plants and the artificial synthesis, have the advantages of low toxicity for the human body and high bacteriostatic action for the propionibacterium acnes, can be prepared into various external medicine dosage forms and cosmetics and have good application prospects.

The invention provides a compound traditional Chinese medical composition which comprises the following components: active ion calcium, podophyllotoxin extract, lygodium japonicum extract, macleaya cordata extract, oleuropein, polygonum cuspidatum extract, usnic acid, essential oil of chaste tree, organic tea tree essential oil, Eastern Indian sandalwood essential oil, sea salt and medical citric acid. The compound traditional Chinese medical composition provided by the invention has superior curative effect and generalization performance and is used as an external medicine which is directly effected on sebaceous gland and mucosa, and is not harmful to a body, not irritant and not allergic. The compound traditional Chinese medical composition not only has positive energy formula of mineral components, but also maintains unique effect of Chinese herbal medicines, and the compound traditional Chinese medical composition is free from any irritation and harm. The compound traditional Chinese medical composition is a pure natural green therapy for removing secret sorrow.

An antibacterial or anti-acne formulation suitable for topical or local application to human skin containing (a) either usnic acid or an usnate and (b) a metal salt selected from copper salts, bismuth salts, and mixtures thereof, wherein if the component (a) is an usnate, the components (a) and (b) are not the same compound.

The invention relates to a usnic acid nano-suspension and its preparation method and application. Specifically, the present invention relates to the usnic acid nanosuspension and its preparation method, as well as its use as a preparation intermediate to prepare other pharmaceutical preparations, and also relates to the pharmaceutical composition prepared from the usnic acid nanosuspension.

The present invention is ultrasonic usnic acid extracting process. Cut usnea is added with 75-98 % concentration alcohol solution in 2-6 times, and ultrasonically extracted at the frequency of 30-50 KHz for 10-50 min, and through further filtering to obtain filtrate, concentrating while recovering alcohol and vacuum freeze drying, usnic acid is obtained. The present invention has high usnic acid extracting rate, can save usnea resource, and has simple technological process, low power consumption and low cost.

The invention discloses a method for extracting usnic acid from cladonia alpestris. The method comprises the following steps: (1) reflux extraction: smashing dry cladonia alpestris into powder, adding ethyl acetate, carrying out reflux extraction for two to three times at the temperature of 70 to 80 DEG C, filtering, merging a filter liquor, and concentrating to obtain a dry extract; (2) recrystallization: dissolving the dry extract with ethyl acetate at the temperature of 70 to 80 DEG C, after cooling to 25 DEG C, quickly (shorter than 1 h), dissolving out and separating usnic acid coarse grain, and then using ethyl acetate for recrystallization so as to obtain usnic acid crystal. The yield of the extracted and separated product is high, the purity is high, meanwhile few types of solvents are used, special equipment is not needed, the preparation period is short, preparation quantity is large, and the method is applicable for mass production.

The invention aims at providing liquid shampoo containing usnic acid and totaxin. The liquid shampoo is characterized by comprising an usnic acid fatty alcohol polyoxyethylene ether complex, a totaxin fatty alcohol polyoxyethylene ether complex, lauryl glucoside, coconut oil alcohol ethoxylate sulfate triethanolamine salt, coconut oil alcohol amide, coconut oil alkyl dimethyl betaine, a pearling agent, a thickener JR400, a slip agent, a pH modifier, a preservative, a chelating agent, essence and purified water. The usnic acid fatty alcohol polyoxyethylene ether complex and the totaxin fatty alcohol polyoxyethylene ether complex have good efficacies of removing scurf and relieving itching on hair of a human body, simultaneously have the efficacies of promoting qi to activate blood, nourishing hair roots, expanding head blood capillaries, promoting blood circulation of the hair roots, and the like, and are also capable of improving the tensile strength and the extensibility of the hair and keeping the hair elastic and not easy to be snapped. The liquid shampoo is purple pearl thick liquid in appearance, and is free of thrill on human skin, and low in toxicity, and the pH value is 6-7.

The invention discloses a method for producing 4‑O‑demethylbarbalicic acid by using Aspergillus terreus strains to synthesize oakmoss, and relates to the technical fields of new strains, microbial fermentation technology and chemical synthesis. The Aspergillus terreus strains are soil Aspergillus terreus (Aspergillus terreus) MEFC06, fermentation culture of Aspergillus terreus species; separation and purification to obtain 4‑O‑desmethyl barbalicic acid, hydrolysis of 4‑O‑desmethyl barbalic acid to 2,4‑dihydroxy‑ 3,6-dimethylbenzoic acid; using a methylating agent to carry out methylation reaction, after the reaction, treatment can obtain 2,4-dihydroxy-3,6-dimethylbenzoic acid methyl ester (synthetic oakmoss ). A new method for producing synthetic oak moss by combining microbial fermentation and chemical synthesis is provided, which is green and ecological, has short synthetic route, simple process and high yield.

The invention relates to an antibacterial Chinese herbal medicine liquid for spray-coating wounds. The antibacterial Chinese herbal medicine liquid solves the problem that the existing disinfectant has high irritation. Extract of Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with purified water having the weight 7-11 times that of the extract so that a water-soluble raw medicine is obtained, and the water-soluble raw medicine is added with usnic acid sodium salt so that the desired product is obtained; or the extract of the Chinese herbal medicines as raw materials subjected to alcohol precipitation is added with a part of purified water so that a water-soluble raw medicine is obtained and then an usnic acid sodium salt aqueous solution prepared from usnic acid sodium salt and the other part of the purified water is added into the water-soluble raw medicine so that the desired product is obtained, wherein a weight ratio of the extract subjected to alcohol precipitation to the two parts of purified water is 1: 7-11 and a weight ratio of usnic acid sodium salt to the water-soluble raw medicine is 1.5-3: 1000. The Chinese herbal medicines as raw materials comprises, by weight, 50-110 parts of common andrographis herb, 50-110 parts of cortex phellodendri, 40-100 parts of radix berberidis, 40-100 parts of Celastrus angulatus, 40-100 parts of isatis root, 40-100 parts of radix sophorae flavescentis, 40-80 parts of mulberry bark, 40-80 parts of santonin, 40-80 parts of aloe, 40-80 parts of fructus rosae laevigatae, 40-80 parts of akebia stem, 40-80 parts of subprostrate sophora, 30-70 parts of Sichuan red orange peel, 30-70 parts of rheum officinale, 30-70 parts of corydalis tuber and 30-70 parts of licorice root. The antibacterial Chinese herbal medicine liquid has the advantages of small irritation, lasting disinfection effect, short treatment course and use convenience.

The invention belongs to the field of pharmacy, and relates to the new application of usnic acid and its derivatives, in particular to the application of usnic acid and its derivatives in the preparation of medicines for treating skin diseases caused by Malassezia bacteria, especially to the use of usnic acid and its derivatives Use of the compound in the preparation of medicines for treating excessive dandruff, seborrheic dermatitis, atopic dermatitis and psoriasis caused by Malassezia bacteria. The present invention is through inhibition experiment, and result shows, and the average value of inhibition circle is 20mm, shows that usnic acid can obviously suppress the growth of Malassezia; The growth of Malassezia was inhibited when the drug concentration gradient of acid and its derivatives increased. The usnic acid and its derivatives of the present invention can be used to prepare medicines for treating skin diseases caused by Malassezia, and can also be used to prepare daily chemical products and external preparations for preventing and treating the above skin diseases.