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Process for supersonically extracting usnic acid

An extraction process, the technology of usnic acid, which is applied in the field of extracting usnic acid by ultrasonic technology, can solve the problems of waste of crude drug resources, long extraction cycle, and low extraction rate, and achieve shortened extraction time, convenient operation, and improved extraction rate. rate effect

Active Publication Date: 2008-10-15
兰州奇正生态健康品有限公司
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  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the extraction of usnic acid generally adopts alcohol extraction or water extraction, which has a long extraction cycle, high cost and low extraction rate, and also wastes crude drug resources.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1, earlier Usnea genus Usnea long without pollution on the Qinghai-Tibet Plateau is cut into sections of 2 to 10 cm, and cleaned with drinking water until the water is clear and colorless, drained; 98% ethanol with 2 times the volume of radishes, extracted for 20 minutes by ultrasonic waves with a frequency of 35KHZ, filtered, and the filtrate was collected; the filtrate was concentrated to a density of 0.8-1.6g / cm3, and vacuum freeze-dried to obtain usnic acid.

Embodiment 2

[0017] Embodiment 2, earlier Usnea genus Usnea long without pollution on the Qinghai-Tibet Plateau is cut into sections of 2-10 cm, and cleaned with drinking water until the water is clear and colorless, drained; then add pine in the Usnea cut section 95% ethanol with 4 times the volume of radishes, extracted for 30 minutes by ultrasonic wave at a frequency of 35KHZ, filtered, and the filtrate was collected; the filtrate was concentrated to a density of 0.8-1.6g / cm3, and vacuum freeze-dried to obtain usnic acid.

Embodiment 3

[0018] Embodiment 3, earlier Usnea genus Usnea long without pollution on the Qinghai-Tibet Plateau is cut into sections of 2-10 cm, and cleaned with drinking water until the water is clear and colorless, drained; then add pine in the Usnea cut section 90% ethanol with 5 times the volume of radishes, extracted for 40 minutes by ultrasonic waves with a frequency of 40KHZ, filtered, and the filtrate was collected; the filtrate was concentrated to a density of 0.8-1.6g / cm3, and vacuum freeze-dried to obtain usnic acid.

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PUM

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Abstract

The present invention is ultrasonic usnic acid extracting process. Cut usnea is added with 75-98 % concentration alcohol solution in 2-6 times, and ultrasonically extracted at the frequency of 30-50 KHz for 10-50 min, and through further filtering to obtain filtrate, concentrating while recovering alcohol and vacuum freeze drying, usnic acid is obtained. The present invention has high usnic acid extracting rate, can save usnea resource, and has simple technological process, low power consumption and low cost.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a process for extracting usnic acid, an organic acid, from Usnea, a crude drug of traditional Chinese medicine, in particular to a process for extracting usnic acid by ultrasonic technology. Background technique [0002] Usnic acid is an organic acid widely present in the lichen plant Usnea, which has antibacterial, anti-Plasmodium and Trichomonas vaginalis effects. Studies have shown that Usnea has no cooling effect on normal body temperature, but has a significant cooling effect on LPS-induced high temperature. Compared with the same amount of aminopyrine (50mg / g, orally), usnic acid has a significant and lasting analgesic effect. According to the research of Xi'an Medical University, the inhibition rate of usnic acid crude product (50-120mg / g) on ​​mouse S180 sarcoma is greater than 65%, indicating that usnic acid has strong anticancer activity. Experiments also sh...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/91A61K36/09A61K125/00
Inventor 雷菊芳
Owner 兰州奇正生态健康品有限公司
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