The invention provides an extraction and purification process method for forsythiaside A in fructus forsythiae leaves. Fat-soluble
pigment and water-soluble impurities in forsythiaside A extract are removed as much as possible before purification, the difficulty of following forsythiaside A purification is lowered, the
chromaticity of the final product forsythiaside A is good, the purity reaches 95%-99%, and the extraction rate reaches 3.5%-5.5%. According to the technical scheme, the method includes the steps that 1, extraction is conducted; 2, extraction is conducted, wherein water is added to concentrate obtained in the step 1 for
dissolution, an extracting solution is obtained, then the pH value is adjusted to be 6,
petroleum ether is added, the fat-soluble
pigment is removed through extraction, and then, most of the water-soluble impurities are removed through extraction through water-saturated normal
butanol, wherein the use amount of water-saturated normal
butanol is 0.5-2 times that of the extracting solution according to the volume ratio, the number of extraction times is 2-4, normal
butanol is recovered, and forsythiaside A extract is obtained; 3,
chromatographic column refining (fed to a 200-300-mesh silicagel column) is conducted, and coarse
crystal substances are obtained; 4, recrystallization is conducted, and a finished product is obtained. The main innovation of the method is shown in extraction in the step 2.