Process for preparing notoginsen triterpenes

A technology of Panax notoginseng saponins and Panax notoginseng, which is applied in the field of preparation of Panax notoginseng saponins, can solve problems such as failure to consider saponin components, difficulty in extracting high purity, poor purity and yield, etc., and achieve saving medicinal materials, The effect of short extraction time and no heating

Inactive Publication Date: 2005-07-06
张平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above preparation method has the following deficiencies: for the poor resolution of this pair of contradictions of purity and yield, the yield declines while the purity improves, and the purity declines while the yield increases, and both can not be well taken into account; macropores Adsorption resin or polyamide or n-butanol extraction is a key step of purification. Due to the limitation of the method itself, it is difficult for the extract

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0036] Example 1

[0037] 10kg of Panax notoginseng stem base (reed head, notch), pulverized, passed through a 60 mesh sieve, added 10 times the amount of water, put into an ultrasonic extraction tank, and carried out ultrasonic vibration extraction, the time was 50 minutes, and the oscillation frequency was 20kHz, Extract 4 times, combine the extracts, centrifuge at 20,000 r / min, pass the centrifuge through the treated D101 macroporous adsorption resin column, first elute with 5 times the column volume of water, and then use 8 times the column volume 75% ethanol solution was eluted, the ethanol eluate was collected, concentrated by rotating scraper film at 50°C, dried and pulverized to obtain powder; the powder was dissolved with 40 times the amount of 50% ethanol, and the chromatographic column particle diameter was 5 μm of octane The preparative high-performance liquid chromatography system using silane-bonded silica gel as the filler was used for separation, eluted with 60...

Example Embodiment

[0038] Example 2

[0039]The main root of Panax notoginseng 10kg, crushed, passed through a 20-mesh sieve, added 6 times the amount of water, put it into an ultrasonic extraction tank, carried out ultrasonic vibration extraction, the time was 20 minutes, the oscillation frequency was 80kHz, extracted 2 times, and combined the extraction liquid, Centrifuge at 12,000 rpm, pass the centrifuge through the treated AB-8 macroporous adsorption resin column, first eluate with 10 times the column volume of water, and then wash with 4 times the column volume of 95% ethanol solution. The ethanol eluent was collected, concentrated by rotating scraping film at 50°C, dried and pulverized to obtain powder; the powder was dissolved with 20 times the amount of 50% ethanol, and the column particle diameter of 15 μm was used to bond silica gel with octadecylsilane. For the preparative high performance liquid chromatography system of the filler, separate it, use 20% ethanol solution to elute, col...

Example Embodiment

[0040] Example 3

[0041] 10 kg of Panax notoginseng roots were crushed, passed through a 40-mesh sieve, 8 times the amount of water was added, put into an ultrasonic extraction tank, and subjected to ultrasonic vibration extraction, the time was 40 minutes, the oscillation frequency was 50 kHz, extracted 3 times, and the extracts were combined. , centrifuge at 16,000 rpm, and the centrifuge passes through the treated D101 macroporous adsorption resin column, first eluted with 8 times the column volume of water, and then eluted with 6 times the column volume of 85% ethanol solution , collect the ethanol eluent, concentrate by rotating scraping film at 50°C, dry and pulverize to obtain powder; dissolve the powder with 30 times the amount of 50% ethanol, and use octadecylsilane-bonded silica gel with a particle diameter of 10 μm in the chromatographic column as The preparative high performance liquid chromatography system of the filler is used for separation, eluting with 40% et...

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Abstract

The invention discloses a method for preparing a notoginseng triterpene. The notoginseng triterpene is obtained from the caudex or axial root or rootlet or leaf of notoginseng by ultrasonic oscillation extraction, macroporous adsorptive resin passing or water saturated n-butyl alcohol extraction and enrichment, reverse preparation type highly effective liquid chromatographic system purification. The purity of the main active site notoginseng triterpene amounts to 98% above. The notoginseng triterpene has a good action for prevention and treatment of cardiovascular and cerebrovascular diseases.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Panax notoginseng saponins. Background technique [0002] Panax notoginseng is a commonly used traditional Chinese medicine in my country, and the total saponins of Panax notoginseng contained in it are its main effective parts. The role of immune function. The medicinal parts of Panax notoginseng include the stem base (reed head, cut mouth), main root, and branch root (tendon), and the leaves of Sanqi also contain a large amount of saponins. The content of total saponins in each medicinal part Differences. In order to obtain high-purity Panax notoginseng saponins, researchers have made unremitting efforts. The patent document of application number 02158727.2 discloses a method for extracting notoginseng saponin, which is obtained by using a water extract over a polar ADS-3 type adsorption resin column, wherein t...

Claims

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Application Information

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IPC IPC(8): A61P7/02A61P9/10A61P29/00A61P37/04C07J9/00C07J17/00C07J71/00
Inventor 张平
Owner 张平
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