Novel technique for preparing pseudo-ginseng red sage root lozenge

A new technology, the technology of Danshen, is applied in the field of new technology for the preparation of Sanqi Danshen buccal tablets, which can solve the problems of not being able to extract Danshensu and affect the curative effect, and achieve the effects of saving medicinal materials, reducing the dosage, and reducing the content of impurities

Inactive Publication Date: 2008-08-20
药都制药集团股份有限公司
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AI Technical Summary

Problems solved by technology

[0005] The disadvantage of the above process is that the active ingredient danshensu contained in the salvia miltiorrhiza cannot be extracted to the maximum extent, and the extraction rate is only 0.1-0.18%, which affects the curative effect.

Method used

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  • Novel technique for preparing pseudo-ginseng red sage root lozenge
  • Novel technique for preparing pseudo-ginseng red sage root lozenge
  • Novel technique for preparing pseudo-ginseng red sage root lozenge

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Embodiment Construction

[0025] Cleanly prepare Danshen medicinal materials, slice them, weigh 1500g, crush Panax notoginseng into coarse powder, weigh 1000g, soak in water for 1 hour, add water to extract four times, combine the extracts, and keep the extracts at 70-100°C for 8 (12)- 36 hours (the longer the holding time, the more extraction rate), concentrated into an extract with a relative density of 1.10-1.30, dried to obtain a dry paste, pulverized into a fine powder, and added with auxiliary materials (xylitol, mannitol or sorbitol 2.5-40 %, citric acid 1-2.5%, aspartame 0-2%), granulated, compressed into tablets, and film-coated.

[0026] It is also possible to carry out alcohol precipitation treatment on the concentrated solution before drying, then reclaim ethanol, concentrate the alcoholic extract, dry to obtain a dry paste, grind it into fine powder, add auxiliary materials (xylitol, mannitol or sorbitol 2.5-40%, Citric acid 1-2.5%, aspartame 0-2%), granulated, compressed into tablets, mad...

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Abstract

The invention relates to a new preparation technology for notoginseng danshen root buccal tablet, comprising the following steps: a danshen root tablet and a notoginseng coarse powder are processed by infiltration, water extraction, extractant mergence, concentration and drying, and a dry extract is obtained; after adding an accessories, granulating and tableting, a primary tablet is prepared or a film-coated tablet is prepared by coating a film; the preparation technology is characterized in that after the step of extractant mergence, the extractant is thermally insulated in 70-100 DEG C for 8-36 hours. The new preparation technology has the advantages of greatly increasing the extraction rate of danshen root in notoginseng danshen root buccal tablet, saving medicinal materials, reducing dosage and enhancing therapeutic effect.

Description

technical field [0001] The invention relates to a new preparation process of Sanqi Danshen buccal tablet, which belongs to the preparation method of Chinese patent medicine. Background technique [0002] Sanqi Danshen Buccal Tablets are modified dosage forms of Sanqi Danshen Granules. Sanqi Danshen Granules are recorded in the Thirteenth Volume of Traditional Chinese Medicine Prescriptions in the "Drug Standards of the Ministry of Health of the People's Republic of China". Long-term use can prevent and treat coronary heart disease and angina pectoris. Pharmacological experiments have proved that Danshensu is an effective anti-ischemic ingredient in Danshen. Danshensu can inhibit platelet synthesis, improve myocardial hypoxia resistance, protect myocardium, increase coronary artery flow, and has anti-oxidation, anti-myocardial ischemia, and blood lipid regulation. And so on. [0003] At present, the preparation process of Sanqishendan buccal tablets is as follows: [0004...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/28A61P9/10
Inventor 李晓恩
Owner 药都制药集团股份有限公司
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