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Improved method of bone strengthening injection production process

A production process and injection technology, applied in the field of medicine, can solve the problems of incomplete extraction of active ingredients, long extraction time, unfavorable human body, etc., and achieve the effects of improving the extraction rate and the utilization rate of raw materials, shortening the extraction time and human body safety.

Inactive Publication Date: 2014-04-09
GUANGXI NANNING BAIHUI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide an improved method for the production process of Jiangu Injection in view of the problems in the production process of Jiangu Injection, such as incomplete extraction of active ingredients, large losses, long extraction time, and impurities that are harmful to the human body. , the production cycle of this method is obviously shortened, the impurities are less, the content of active ingredients is high, the operation is simple, and the production efficiency is improved

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  • Improved method of bone strengthening injection production process

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Effect test

Embodiment 1

[0019] An improved method for the production process of Jiangu injection, comprising the following steps:

[0020] 1. Take 2500g of Zhagu medicinal material, wash, dry, crush, and pass through a 40-mesh sieve to obtain Zangu medicinal material powder;

[0021] 2. Put the war bone medicinal material powder into the ultrasonic extraction tank, add 6 times the amount of 40% ethanol for ultrasonic vibration extraction, the time is 40 minutes, the oscillation frequency is 50kHz, the temperature is controlled at room temperature, extracted 3 times, filtered, combined extraction Liquid, get the raw liquid of war bone medicinal material;

[0022] 3. The stock solution of warbone medicinal materials is recovered under reduced pressure below 60°C to ethanol, concentrated to a clear paste with a relative density of 1.15 (50°C), passed through a D101 macroporous adsorption resin column (the ratio of medicinal materials to resin is 1:2), and water Elute until the eluent is colorless, then...

Embodiment 2

[0025] An improved method for the production process of Jiangu injection, comprising the following steps:

[0026] 1. Take 2500g of the war bone medicinal material, wash, dry, crush, and pass through a 50-mesh sieve to obtain the war bone medicinal material powder;

[0027] 2. Put the war bone medicinal material powder into the ultrasonic extraction tank, add 8 times the amount of 40% ethanol for ultrasonic vibration extraction, the time is 20 minutes, the oscillation frequency is 100kHz, the temperature is controlled at room temperature, extracted twice, filtered, combined extraction Liquid, get the raw liquid of war bone medicinal material;

[0028] 3. The stock solution of warbone medicinal material is recovered under reduced pressure below 60°C to ethanol, concentrated to a clear paste with a relative density of 1.20 (50°C), passed through a D101 macroporous adsorption resin column (the ratio of medicinal material to resin is 1:3), and water Elute until the eluent is colo...

Embodiment 3

[0031] An improved method for the production process of Jiangu injection, comprising the following steps:

[0032] 1. Take 2500g of the war bone medicinal material, wash, dry, crush, and pass through a 50-mesh sieve to obtain the war bone medicinal material powder;

[0033] 2. Put the war bone medicinal material powder into the ultrasonic extraction tank, add 7 times the amount of 40% ethanol for ultrasonic vibration extraction, the time is 30 minutes, the oscillation frequency is 80kHz, the temperature is controlled at room temperature, extracted 3 times, filtered, combined extraction Liquid, get the raw liquid of war bone medicinal material;

[0034] 3. The stock solution of warbone medicinal material is recovered under reduced pressure below 60°C to ethanol, concentrated to a clear paste with a relative density of 1.18 (50°C), passed through a D101 macroporous adsorption resin column (the ratio of medicinal material to resin is 1:3), and water Elute until the eluent is col...

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Abstract

The invention discloses an improved method of a bone strengthening injection production process. The method comprises the following steps: putting the caulis premnae fulvae medicine powder into an ultrasonic extraction pot, adding 40% ethanol 6-8 times the caulis premnae fulvae medicine powder in quantity, and performing ultrasonic oscillation extraction for 20-40 minutes, wherein the oscillation frequency is 50-100kHz; controlling the temperature at room temperature; extracting for 2-3 times, and filtering; combining the extracting solutions to obtain a stock solution of caulis premnae fulvae medicine; performing reduced-pressure recovery of ethanol from the stock solution of caulis premnae fulvae medicine at a temperature below 60 DEG C, and concentrating into a cream with relative density of 1.15-1.20 (50 DEG C); eluting with water through a D101 type macroporous resin adsorption column until the eluent is colorless; eluting with 40% ethanol 3-5 times the column in volume; collecting the ethanol eluent, and performing reduced-pressure recovery of ethanol at a temperature below 60 DEG C to obtain a concentrated solution of caulis premnae fulvae medicine; and producing according to the original production process to obtain a finished product. The method greatly shortens the extraction time, improves the extraction rate of active ingredients and the utilization rate of raw materials, and is simple to operate and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of medicines and relates to an improved method for the production process of Jiangu injection. Background technique [0002] Jiangu Injection is recorded in the "Standards Issued by the Ministry of Traditional Chinese Medicine" (Volume 14), the standard number is WS3-B-2768-97, and it is an injection made from Zhangu (stem). The medicinal materials of Zhangu come from The dry stem of the Verbenaceae Tofu Chai plant, Premna fulva Craib. "Standard issued by the Ministry of Traditional Chinese Medicine" records that Jiangu Injection [Functions and Indications]: promotes blood circulation and dissipates blood stasis, strengthens tendons and bones, dispels wind and relieves pain; it is used for vertebral hyperostosis, and it is also effective for rheumatic joint pain. Since its launch, Jiangu Injection has achieved certain curative effect in clinical practice. [0003] The Chinese patent with application number 94101711....

Claims

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Application Information

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IPC IPC(8): A61K36/85A61K9/08
Inventor 王静宇杜日建
Owner GUANGXI NANNING BAIHUI PHARMA GRP
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