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Novel technology of extracting salvianic acid from salvia miltiorrhiza

A new technology of danshensu, which is applied in the field of new extraction technology of danshensu in danshensu, can solve the problems of inability to extract danshensu, waste, etc., and achieve the effects of saving medicinal materials, increasing extraction rate, and light color of the solution

Inactive Publication Date: 2008-07-30
药都制药集团股份有限公司
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AI Technical Summary

Problems solved by technology

[0007] None of the above-mentioned traditional extraction techniques can extract the active ingredient Danshensu contained in Salvia miltiorrhiza to the maximum extent, and the extraction rate is only 0.10-0.18% (calculated according to the amount of crude drug), resulting in a great waste

Method used

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  • Novel technology of extracting salvianic acid from salvia miltiorrhiza
  • Novel technology of extracting salvianic acid from salvia miltiorrhiza
  • Novel technology of extracting salvianic acid from salvia miltiorrhiza

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Embodiment Construction

[0026] Clean the Danshen medicinal material, cut into slices, soak in water for 1 hour, add water to extract four times, combine the extracts, keep the extracts at 70-100°C for 8-36 hours (the longer the holding time, the higher the extraction rate), concentrate, and dry Get Danshen dry paste.

[0027] It is also possible to carry out alcohol precipitation treatment on the concentrated solution before drying, then recover ethanol, concentrate the alcoholic extract, and dry to obtain the dry extract of Danshen.

[0028] Schedule 1

[0029]

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Abstract

The invention relates to a new extraction process of tanshinol from salvia. The dry extract of salvia is obtained by the steps of infiltrating salvia pieces, extracting, combining the extract, concentrating and drying. The invention is characterized in that the extract is kept for insulation from 70 DEG C to 100 DEG C for 8 to 36 hours after the step of combining the extract. The beneficial effects of the invention are: improving the extraction rate of tanshinol in salvia material greatly; making full use of the effective components in salvia material and saving the medicinal materials greatly; the invention does not need to add any other chemical materials, the color of the solution is shallow, and the invention greatly reduces the occurrence of secondary pollutant, so the produced medicine is much safer; the invention can support the research and development of new medicine of the effective position of salvia, reduce dosage, and improve efficacy.

Description

technical field [0001] The invention relates to a new extraction process of danshensu in salvia miltiorrhiza, belonging to the extraction method of effective components of traditional Chinese medicine. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia mikltiorrhiza Bge. It is a commonly used traditional Chinese medicine, which has the effects of dispelling blood stasis and relieving pain, promoting blood circulation and promoting menstruation, clearing heart and eliminating troubles. It is clinically used in the treatment of stroke, coronary heart disease, and viral myocarditis in children. Its water-soluble components mainly include danshensu, protocatechualdehyde, and salvianolic acid. It has been proved by pharmacological experiments that Danshensu is an active ingredient in Danshen against myocardial ischemia. Danshensu can inhibit platelet synthesis, improve myocardial hypoxia resistance, protect myocardium, increase coronary arte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P3/06A61P9/10A61P39/06A61K125/00
Inventor 李晓恩
Owner 药都制药集团股份有限公司
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