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Heart-benefiting pulse-invigorating injection and its preparation process

An injection preparation and preparation technology, applied in the field of Yixin Fumai injection preparation and its preparation, can solve the problems of limited therapeutic effect, low bioavailability, no reports of Yixin Fumai injection preparation, etc., and achieve the convenience of the impurity removal process , high extraction rate and high extraction rate

Inactive Publication Date: 2005-11-23
张海峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned preparations are oral preparations with low bioavailability, and the therapeutic effect is greatly limited.
[0004] No reports about Yixinfumai injection preparations were found in the data search

Method used

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  • Heart-benefiting pulse-invigorating injection and its preparation process
  • Heart-benefiting pulse-invigorating injection and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0067] (1) The raw materials are: raw sun-dried ginseng 4kg, Ophiopogon japonicus 4kg, Schisandra chinensis 3kg, Astragalus membranaceus 4kg, Salvia miltiorrhiza 5kg, Rhizoma chuanxiong 3kg.

[0068] (2) Take the above-mentioned Rhizoma Chuanxiong and Schisandra, crush them, add 8 times the amount of water to soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the volatile oil, and use the water extract for later use; dissolve it with a small amount of ethanol, and slowly add it to 20 times the amount In a saturated solution made of HP-β-CD, stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 0.8 kg of clathrate.

[0069] (3) Take the above-mentioned raw sun-dried ginseng, Ophiopogon japonicus, Radix Astragali, and Salvia miltiorrhiza, and combine them with Rhizoma Chuanxiong and Schisandra herb residues, put them into an ultrasonic extraction tank, add 8 ...

Embodiment 2

[0072] (1) The raw materials are: raw sun-dried ginseng 2kg, Ophiopogon japonicus 2kg, Schisandra chinensis 1kg, Astragalus 2kg, Salvia miltiorrhiza 3kg, Rhizoma chuanxiong 1kg.

[0073] (2) Take the above-mentioned Rhizoma Chuanxiong and Schisandra, crush them, add 8 times the amount of water to soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the volatile oil, and use the water extract for later use; dissolve with a small amount of ethanol, slowly add to 10 times the amount In a saturated solution made of HP-β-CD, stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 0.4kg of clathrate.

[0074] (3) Take the above-mentioned raw sun-dried ginseng, Ophiopogon japonicus, Radix Astragali, and Salvia miltiorrhiza, and combine them with Rhizoma Chuanxiong and Schisandra dregs, put them into an ultrasonic extraction tank, add 8 times the amount of 40% ethanol ...

Embodiment 3

[0077] (1) The raw materials are: raw sun-dried ginseng 3kg, Ophiopogon japonicus 3kg, Schisandra chinensis 2kg, Astragalus 3kg, Salvia miltiorrhiza 4kg, Rhizoma chuanxiong 2kg.

[0078] (2) Take the above-mentioned Rhizoma Chuanxiong and Schisandra, crush them, add 8 times the amount of water to soak for 1 hour, extract the volatile oil by steam distillation for 4 hours, collect the volatile oil, and use the water extract for later use; dissolve it with a small amount of ethanol, and slowly add it to 15 times the amount In a saturated solution made of HP-β-CD, stir at 50°C for 3 hours, then stir at room temperature for another 2 hours, let stand overnight, filter, and dry at low temperature to obtain 0.6 kg of clathrate.

[0079] (3) Take the above-mentioned raw sun-dried ginseng, Ophiopogon japonicus, Radix Astragali, and Salvia miltiorrhiza, and combine them with Rhizoma Chuanxiong and Schisandra herb residues, put them into an ultrasonic extraction tank, add 8 times the amo...

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Abstract

The invention relates to a heart-benefiting pulse-invigorating injection which is prepared from the raw materials of chuanxiong rhizome, schisandra chinensis volatile oil, HP-beta-CD, sun-dried ginseng, lilyturf root, astragalus root, salvia miltiorrhizae and water-soluble medicinal auxiliary materials for injection. The invention also discloses the process for preparing the injection.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and in particular relates to a Yixin Fumai injection preparation and a preparation method thereof. Background technique [0002] Yixin Fumai Granules [Ministry of Traditional Chinese Medicine 19 volumes] prepared from sun-dried ginseng, Ophiopogon japonicus, Schisandra chinensis, Astragalus root, Salvia miltiorrhiza, and Chuanxiong has the functions of nourishing qi and nourishing yin, promoting blood circulation, rejuvenating pulse, promoting qi and blood circulation, and removing blood stasis. The efficacy of collaterals; special effects in the treatment of various types of ischemic heart disease; Symptoms include chest obstruction and heart pain, chest tightness and discomfort, palpitations, shortness of breath and fatigue, and pulse knots; it is used for coronary heart disease, angina pectoris, hidden coronary heart disease, myocarditis, rheumatic heart disease, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 张海峰
Owner 张海峰
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