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Traditional Chinese medicine oral liquid containing premna fulva craib and preparation method of oral liquid

A technology of traditional Chinese medicine oral liquid and oral liquid, which is applied in the field of medicine and achieves the effects of less allergic reaction, high bioavailability and convenient taking.

Inactive Publication Date: 2014-04-02
GUANGXI NANNING BAIHUI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to provide a traditional Chinese medicine oral liquid containing Zhangu in view of the adverse reactions of Jiangu injection in clinical practice. It has been proved by pharmacology and clinical practice that the oral liquid has the functions of promoting blood circulation and dispelling blood stasis, strengthening tendons and bones, and dispelling wind. Analgesic effect, can be used for hyperosteogeny of the spine, and also has curative effect on rheumatic joint pain, and the present invention also has the advantages of fast absorption, stable quality, and convenient administration

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A preparation method of a traditional Chinese medicine oral liquid containing war bones, comprising the following steps:

[0023] 1. Take 5kg of the warbone medicinal material, crush it, and pass through a 40-mesh sieve to obtain the war-bone medicinal material powder;

[0024] 2. Put the war bone powder into the ultrasonic extraction tank, add 6 times the amount of 40% ethanol for ultrasonic vibration extraction, the time is 20 minutes, the oscillation frequency is 50kHz, the temperature is controlled at room temperature, extracted 3 times, filtered, combined extraction Liquid, recovery of ethanol under reduced pressure below 60°C, concentrated to a relative density of 1.20 (50°C) Dezhangu herbal extract;

[0025] 3. Add 6 times the amount of water to the obtained war bone medicinal material extract, stir well, let it stand for 24 hours, and filter the supernatant;

[0026] 4. Concentrate the supernatant to an appropriate amount, add 3 g of sodium benzoate and 0.5 g o...

Embodiment 2

[0028] A preparation method of a traditional Chinese medicine oral liquid containing war bones, comprising the following steps:

[0029] 1. Take 5kg of Zhagu medicinal material, crush it, and pass through a 50-mesh sieve to obtain Zangu medicinal material powder;

[0030] 2. Put the war bone medicinal material powder into the ultrasonic extraction tank, add 8 times the amount of 40% ethanol for ultrasonic oscillation extraction, the time is 40 minutes, the oscillation frequency is 100kHz, the temperature is controlled at room temperature, extracted twice, filtered, combined extraction Liquid, recovery of ethanol under reduced pressure below 60°C, concentrated to a relative density of 1.25 (50°C) Dezhangu herbal extract;

[0031] 3. Add 10 times the amount of water to the obtained war bone medicinal material extract, stir well, let it stand for 48 hours, and filter the supernatant;

[0032] 4. Concentrate the supernatant to an appropriate amount, add 3 g of sodium benzoate and...

Embodiment 3

[0034] A preparation method of a traditional Chinese medicine oral liquid containing war bones, comprising the following steps:

[0035] 1. Take 5kg of the warbone medicinal material, crush it, and pass through a 40-mesh sieve to obtain the war-bone medicinal material powder;

[0036] 2. Put the war bone powder into the ultrasonic extraction tank, add 7 times the amount of 40% ethanol for ultrasonic vibration extraction, the time is 30 minutes, the oscillation frequency is 100kHz, the temperature is controlled at room temperature, extracted 3 times, filtered, combined extraction Liquid, ethanol is recovered under reduced pressure below 60°C, and concentrated to a relative density of 1.22 (50°C) Dezhangu herbal extract;

[0037] 3. Add 8 times the amount of water to the obtained war bone medicinal material extract, stir well, let it stand for 48 hours, and filter the supernatant;

[0038] 4. Concentrate the supernatant to an appropriate amount, add 3 g of sodium benzoate and 0...

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PUM

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Abstract

The invention discloses traditional Chinese medicine oral liquid containing premna fulva craib and a preparation method of the oral liquid. A premna fulva craib medicinal material extracting solution is used as the active ingredient of the oral liquid, and pharmaceutically acceptable additives are added in the active ingredient to prepare 10 L oral liquid, and the premna fulva craib medicinal material extracting solution is extracted by the following method: crushing 5 kg of premna fulva craib medicinal material, and filtering the powder through a sieve of 40-50 meshes to obtain premna fulva craib medicinal material powder; putting the premna fulva craib medicinal material powder in an ultrasonic extracting tank, adding 6-8 times of 40% ethanol to carry out ultrasonic oscillation extraction, wherein the ultrasonic oscillation extraction time is 20-40 minutes and the oscillation frequency is 50-100 kHz, controlling the temperature to be lower than 50 DEG C, extracting for 2-3 times, filtering, mixing the extracting solutions, decompression recycling ethanol below 60 DEG C, and concentrating the mixed extracting solution to relative density of 1.20-1.25 (50 DEG C) to obtain the premna fulva craib medicinal material extracting solution. The traditional Chinese medicine oral liquid disclosed by the invention has the functions of promoting blood circulation and removing blood stasis, strengthening tendons and bones and dispelling wind-evil and relieving pain, the traditional Chinese medicine oral liquid can be used for treating vertebral bone hyperplasia and also has a curative effect on rheumatic arthralgia, and the traditional Chinese medicine oral liquid has the advantages of non-allergic reaction and small side effect and provides a safe and effective drug choice for the majority of patients.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a traditional Chinese medicine oral liquid containing war bones and a preparation method thereof. Background technique [0002] Zhangu medicinal material is recorded in the 1990 edition of "Guangxi Standards of Chinese Medicinal Materials". It is derived from the dried stem of Premna fulva Craib, a plant of the genus Verbenaceae. Guangxi Huanbao Pharmaceutical Co., Ltd. uses war bone, swollen joint wind, Corydalis corydalis, natural copper, salvia miltiorrhiza, achyranthes bidentata, and Eucommia as raw materials to produce "Dieda Shenggu Granules", which have the functions of promoting blood circulation and removing stasis, reducing swelling and pain, strengthening muscles and bones function. The "Jiangu Injection" produced by our company is a pure Chinese medicine preparation extracted by modern technology. Stem) processed into the injection, "Standard issued by the Ministry of Traditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/00A61P29/00A61P19/08A61K135/00
Inventor 郭雄张乃汉
Owner GUANGXI NANNING BAIHUI PHARMA GRP
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