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Usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in preparation of oral care product

A supramolecular complex and cyclodextrin technology is applied in the field of supramolecular complexes to achieve the effects of improving solubility, simple preparation method and solving poor solubility of usnic acid

Active Publication Date: 2018-10-12
CHONGQING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned encapsulation process is only suitable for oral direct application

Method used

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  • Usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in preparation of oral care product
  • Usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in preparation of oral care product
  • Usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in preparation of oral care product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The investigation of embodiment 1 different cyclodextrin derivatives to the solubilization of usnic acid

[0042] Study on Phase Solubility of Usnic Acid in β-CD and Its Cyclodextrin Derivatives

[0043] Prepare a series of different concentrations of α-CD solutions (0, 0.625, 1.25, 2.5, 5, 7.5, 10, 12.5%, w / v), β-CD solutions (0, 0.25, 0.5, 0.75, 1.0, 1.25, 1.5, 1.75%, w / v), γ-CD solution (0, 1.25, 2.5, 5, 10, 15, 20, 25%, w / v), HP-β-CD solution (0, 2.5, 5, 10, 20, 30, 40, 50%, w / v) and SBE-β-CD solutions (0, 2.5, 5, 10, 20, 30, 40, 50%, w / v). Pipette 5 mL of the above solution and place them in 10 mL centrifuge plastic tubes, and add excess usnic acid raw material (50 mg per portion) to the above medium respectively, and mix well. Put them into a constant temperature oscillating water bath shaker and shake at two temperatures of 25°C and 37°C for 72h. Take out the sample, centrifuge at 8000rpm for 30min, absorb the supernatant and dilute to a certain multiple, and ...

Embodiment 2

[0067] Example 2 Investigation of the preparation method of supramolecular complexes of different cyclodextrin derivatives of usnic acid

[0068] 1. Preparation method

[0069] 1.1 Reverse mixing and stirring method: Take a certain amount of cyclodextrin derivatives in a container, add 50mL of pH buffer solution or distilled water in each experiment and stir until dissolved. Another certain amount of usnic acid was taken, stirred and dissolved in acetone (30mL). Slowly add the cyclodextrin derivative aqueous solution into the usnic acid acetone solution, rotate at 800rpm, stir at a constant temperature of 60°C for a certain period of time, evaporate the acetone, cool to room temperature, put it in the refrigerator for 24 hours, freeze-dry, and use ethyl acetate to dry the dried product Rinse 3 times (10mL / time), evaporate ethyl acetate, and vacuum-dry under reduced pressure to obtain the supramolecular complex of usnic acid cyclodextrin derivatives for future use. Calculate ...

Embodiment 3

[0116] The preparation of embodiment 3UA-SBE-β-CD oral care product

[0117] 1. Mouthwash

[0118] 1) The formula composition of mouthwash: including antibacterial agent, fresh fragrance agent, sweetener, solvent. Bacteriostatic agent is the sulfobutyl-beta-cyclodextrin (UA-SBE-beta-CD) supramolecular complex of active substance usnic acid (UA); fragrance agent selects peppermint oil, orange peel oil, green tea extract, One or more of propolis extract, surfactant selected from any of non-ionic or zwitterionic surfactants, sweetener selected from one or more of stevioside, xylitol, sorbitol , the solvent is deionized water. The formula is as follows (by weight):

[0119]

[0120]

[0121]

[0122] 2) Preparation method: take the bacteriostatic agent in the formula and fully dissolve it with 3 / 4 of the full prescription amount of deionized water, then add the fragrance agent, surfactant, and sweetener in turn to stir and dissolve, and then add it to the full formula ...

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Abstract

The invention provides an usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex and its use in oral care. The supramolecular complex is prepared from sulfobutyl-beta-cyclodextrin and usnic acid coated with the sulfobutyl-beta-cyclodextrin. The usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex is prepared through a simple method and solves the technical problem of poor solubility of usnic acid. The invention provides an oral care product of the usnic acid-sulfobutyl-beta-cyclodextrin supramolecular complex. The formula has good effects of preventing dental caries, ozostomia and dental ulcer.

Description

technical field [0001] The invention relates to a supramolecular complex, more specifically to a usnic acid-sulfobutyl-β-cyclodextrin supramolecular complex and its application in preparing oral care products. technical background [0002] The oral cavity is a complex and complete micro-ecological system, which provides a suitable environment and conditions for the growth and reproduction of various microorganisms. Modern studies have shown that the occurrence of common oral diseases such as dental caries, periodontal disease, gingivitis, and oral ulcers are all related to the growth and reproduction of harmful bacteria in the oral cavity. Therefore, maintaining the balance of microbial populations in the oral cavity and preventing harmful bacteria from multiplying in the oral cavity play an important role in maintaining oral health. [0003] At present, the treatment of oral diseases mainly relies on the use of broad-spectrum chemical fungicides, antibiotics and other meth...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/343A61K9/12A61K9/06A61P31/02A61P1/02A61P31/04A61K8/73A61K8/49A61K8/04A61Q11/00
CPCA61K8/042A61K8/046A61K8/4973A61K8/738A61K9/006A61K9/06A61K9/12A61K31/343A61Q11/00
Inventor 赵颖赵臻邱聪慧顾培林杨凤谭杨
Owner CHONGQING UNIV OF TECH
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