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Medicinal composition containing zaltoprofen and capsule preparation method thereof

A composition and drug technology, applied in the directions of drug combination, capsule delivery, effective components of heterocyclic compounds, etc., can solve problems such as high price, and achieve the effects of easy storage, reasonable ratio, and safe and effective clinical use.

Inactive Publication Date: 2013-03-06
XIAN TAKOMED PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the safety problems brought about by COX-2 inhibitors have made doctors and patients question the drugs; at the same time, the price of COX-2 inhibitors is often relatively expensive, so its main market growth occurs in developed countries, and most of the domestic patients Unable to afford expensive medical expenses for a long time, therefore, for most domestic patients, they prefer traditional NSAIDs with good curative effect and low side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Capsules for the treatment of arthritis are made using the following steps:

[0024] a) Formula: (Specification 80mg)

[0025] Zaltobuprofen 81g

[0026] Anhydrous glucose 84g

[0027] Starch 110g

[0028] Magnesium Stearate 15g

[0029] 7%pvp ethanol solution 10g

[0030] Make 1000 capsules, each capsule is 0.3g.

[0031] b) Pass step a) 81g zaltoprofen, 84g anhydrous glucose and 120g starch through a 20-100 mesh sieve;

[0032] c) Mix the zaltoprofen, anhydrous glucose, and starch sieved in step b) evenly, and add 10 g of soft material in 7% pvp ethanol solution;

[0033] d) Soft materials are granulated with a 10-40 mesh sieve, and air-dried at 50-60°C;

[0034] e) Sieve 10-60 mesh, add 15g of magnesium stearate, and mix well;

[0035] f) Capsules are filled and packaged.

Embodiment 2

[0037] Capsules for arthritis are made using the following steps:

[0038] a) Formula: (Specification 80mg)

[0039]Zaltobuprofen 81g

[0040] Microcrystalline Cellulose 130g

[0041] Sucrose 54g

[0042] Magnesium Stearate 15g

[0043] The concentration is 65% ethanol solution 20g

[0044] Make 1000 capsules, each capsule is 0.3g.

[0045] b) Pass step a) 81g zaltoprofen, 150g microcrystalline cellulose, 54g sucrose through a 20-100 mesh sieve;

[0046] c) Mix step b) zaltoprofen, microcrystalline cellulose, and sucrose evenly, and add a soft material made of ethanol with a concentration of 65%;

[0047] d) Soft materials are granulated with a 10-40 mesh sieve, and air-dried at 50-60°C;

[0048] e) Sieve 10-60 mesh, add 15g of magnesium stearate, and mix well;

[0049] f) Capsules are filled and packaged.

Embodiment 3

[0051] Capsules for arthritis are made using the following steps:

[0052] a) Formula: (Specification 80mg)

[0053] Zaltobuprofen 81g

[0054] Starch 60g

[0055] Microcrystalline Cellulose 124g

[0056] Magnesium Stearate 15g

[0057] The concentration is 10% starch slurry 20g

[0058] Make 1000 capsules, each capsule is 0.3g.

[0059] b) Pass step a) 81g zaltoprofen, 60g starch, and 144g microcrystalline cellulose through a 20-100 mesh sieve;

[0060] c) Mix step b) Zaltobuprofen, starch, and microcrystalline cellulose evenly, and add starch slurry with a concentration of 10% to make a soft material;

[0061] d) Soft materials are granulated with a 10-40 mesh sieve, and air-dried at 50-60°C;

[0062] e) Sieve 10-60 mesh, add 15g of magnesium stearate, and mix well;

[0063] f) Capsules are filled and packaged.

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PUM

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Abstract

The invention discloses a medicinal composition containing zaltoprofen and a capsule preparation method thereof. The medicinal composition containing the zaltoprofen has the efficacies of treating chronic rheumotoid arthrosis, deforming arthritis, lower back pain, periarthritis of shoulder, neck, shoulder and wrist syndrome as well as anti-inflammatory analgesic efficacies after surgery, trauma and tooth extraction. The medicinal composition is formed by processing through a scientific and reasonable production process. The medicinal composition has the advantages of definite functions, controllable quality and safety in taking. The medicinal composition is simple in preparation method and can be prepared by conventional equipment.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a pharmaceutical composition containing zaltoprofen and a method for preparing capsules thereof. Background technique [0002] Arthritis generally refers to inflammatory diseases that occur in human joints and their surrounding tissues, and can be divided into dozens of types. There are more than 100 million arthritis patients in my country, and the number is increasing. The clinical manifestations are joint redness, swelling, heat, pain, dysfunction and joint deformity. In severe cases, it will lead to joint disability and affect the quality of life of patients. [0003] The relationship between arthritis and the environment, especially infection, cannot be ignored. Post-streptococcal arthritis, reactive arthritis, and infectious arthritis are all directly related to infection. Pathogenic bacterial infection may also be one of the inducing factors of autoimmune diseases such as rheum...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/38A61P29/00A61P19/02
Inventor 唐永红钱博
Owner XIAN TAKOMED PHARMA TECH
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