Neomycin sulfate fermentation method

A neomycin sulfate and fermenter technology, applied in the biological field, can solve problems such as unstable quality of peanut cakes, reduce the difficulty of fermentation process control and adjustment, reduce unqualified product returns, and improve supply reliability Effect
CN102965417AInactive Publication Date: 2013-03-13YICHANG SANXIA PHARMA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
YICHANG SANXIA PHARMA
Publication Date
2013-03-13
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a neomycin sulfate fermentation method. The method is characterized by comprising the following steps of: (1) culturing bevel spores: preparing the bevel spores from sandy soil spores; (2) culturing a bevel spore suspension: culturing the bevel spores for 4-12 days at the temperature of 28+ / -2 DEG C, thereby preparing the bevel spore suspension; (3) culturing in a seeding tank: putting the bevel spore suspension in the seeding tank for culturing, wherein the mass content of peanut meal in the seeding tank is 1-2% the mass of culture fluid in the seeding tank; (4) culturing in a fermentation tank: feeding the culture fluid cultured by the seeding tank to the fermentation tank for culturing, wherein the mass content of the peanut meal in culture fluid in the fermentation tank is 0-4% the mass of the culture fluid in the fermentation tank; and (5) diluting fermentation broth into diluted fermentation broth, thereby completing the fermentation step. The neomycin sulfate fermentation method provided by the invention has the advantages that the problem of quality instability of peanut cakes can be solved, and the fermentation production of neomycin is effectively guaranteed.
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Description

technical field

[0001] The invention relates to the field of biotechnology, in particular to a neomycin sulfate fermentation method. Background technique

[0002] The raw materials used in the existing domestic neomycin fermentation are mainly grain processing raw materials, such as broken rice, peanut cake, soybean cake, etc. In order to improve the bioavailability of these raw materials, the above raw materials usually need to be crushed and sieved , to make rice flour, peanut flour and soybean flour.

[0003] In order to save costs, at present, manufacturing enterprises have long used peanut cakes as raw materials for neomycin fermentation production. Peanut cakes are mainly the residues obtained after hot pressing or cold pressing of peanuts. Since peanut cakes are mostly produced in small farm workshops, there are Unstable quality, uneven quality, black peanut cakes due to lax processing control in small workshops (normal peanut cakes should be brown), the color of bla...

Claims

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