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Preparation method and application of cold-fever tablet

An antipyretic tablet and extraction technology, which is applied in the field of preparation of cold antipyretic tablets, can solve the problems of large dosage, many impurities, and inconvenient taking for patients, and achieve the effect of reducing the dosage

Inactive Publication Date: 2013-03-20
刘殿华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of cold antipyretic tablets. However, the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , seriously affected the clinical application of this product

Method used

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  • Preparation method and application of cold-fever tablet

Examples

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Comparison scheme
Effect test

Embodiment 1

[0025] Take 168g of Radix Isatidis, 126g of Schizonepetae, 126g of Fist Ginseng, 126g of Pueraria Mirifica, and 126g of Bupleurum, add Bupleurum to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 150min, and the supercritical extract is obtained for later use; the rest of the traditional Chinese medicine is taken, pulverized, added with 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, the extraction power is 400W, and the extraction is performed twice, Combine the extracts for 4 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , ...

Embodiment 2

[0028] Take 168g of Radix Isatidis, 126g of Schizonepetae, 126g of Fist Ginseng, 126g of Pueraria Mirifica, and 126g of Bupleurum, add Bupleurum to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set aside; mix the abov...

Embodiment 3

[0031] Take 168g of Radix Isatidis, 126g of Schizonepetae, 126g of Fist Ginseng, 126g of Pueraria Mirifica, and 126g of Bupleurum, add Bupleurum to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extract , set aside; m...

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Abstract

The invention provides a preparation method and an application of a cold-fever tablet. The cold-fever tablet is prepared by using 168 g of isatis roots, 126 g of schizonepeta ears, 126 g of bistort roots, 126 g of pueraria mirifica and 126 g of radix bupleuri as raw material drugs via supercritical extraction and microwave-assisted extraction, so that puerarin content in the tablet is increased greatly. The invention also provides the application of the cold-fever tablet in preparing the drug of inhibiting cell proliferation of mouse melanoma lung metastatic lines B16-F10.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a cold-reducing fever tablet. Background technique [0002] Ganmao antipyretic tablet is recorded in the standard WS3-B-0448-90 of the Ministry of Health. It is made of 168g of Radix Radix, 126g of Schizonepetae, 126g of Quanshen, 126g of Pueraria Mirifica, and 126g of Bupleuri. It is used for sore limbs caused by internal heat and external cold, fever and fear of cold, runny nose, cough and itchy throat. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of cold antipyretic tablets, but the method of powdering and decocting in water is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. , Seriously affecting the clinical application of this product. C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K9/20A61P11/00A61P35/00A61P35/04
Inventor 不公告发明人
Owner 刘殿华
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