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Mass Spec Ion Tuning Methods

An ion and mass spectrometry technology, applied in the field of mass spectrometry, can solve the problems of poor quantitative stability of trace components, increased labor maintenance costs, easy contamination of instruments, etc., to achieve optimal analysis stability, reduce human interference, and optimize analysis speed Effect

Active Publication Date: 2015-11-25
FOCUSED PHOTONICS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] 1. The instrument is easy to be polluted, and manual cleaning is required after contamination, which increases the cost of manual maintenance;
[0007] 2. Poor quantitative stability for trace components

Method used

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  • Mass Spec Ion Tuning Methods

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Effect test

Embodiment 1

[0035] figure 1 The flowchart of the mass spectrometry ion tuning method of the embodiment of the present invention is schematically given, such as figure 1 As shown, the tuning method includes ion ionization tuning, and the ion ionization tuning includes the following steps:

[0036] (A1) Select a reference gas, such as argon, helium, etc., and pass the reference gas into the mass spectrometer to obtain the ion signal intensity I corresponding to the reference gas 0 ;

[0037] (A2) During the measurement process, pass the reference gas into the mass spectrometer to obtain the ion signal intensity I corresponding to the reference gas 1 ;

[0038] (A3) If the I 1 ≥K·I 0 , K is a set constant, such as 0.8, the mass spectrometer detects the object to be tested;

[0039] If the I 1 0 , Increase the working voltage and filament working current of the ion source electrode of the mass spectrometer, and continue for a period of time, and then restore the original working voltage and current to...

Embodiment 2

[0052] An application example of the tuning method according to Embodiment 1 of the present invention. The measured gas contains H 2 (Concentration 20-50%), CO (concentration 20-50%), CO 2 (Concentration 50~70%), O 2 (Concentration 0.01~0.1%), the quantitative ions are M / Z2, M / Z28, M / Z44, M / Z32. Ar is used as the reference gas for ion ionization tuning, and its reference ion is M / Z40.

[0053] The tuning method specifically includes the following steps:

[0054] (B0) Set relevant tuning parameters:

[0055] The quantitative ion scan time of the measured component is set, assuming T respectively 1 =0.1s, T 2 =0.1s, T 3 =0.1s, T 4 = 0.3s, respectively the minimum scanning time;

[0056] The maximum scanning time of quantitative ions Tn=2s;

[0057] Ionization tuning times t;

[0058] Ionization tuning time T;

[0059] Maximum filament tuning current I Tuning ;

[0060] Filament working current I set up ;

[0061] The filament current increment is 0.1A;

[0062] Ion tuning signal-to-noise ...

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Abstract

The invention provides a mass spectrum ion tuning method. The mass spectrum ion tuning method comprises ion ionization tuning, wherein the ion ionization tuning comprises the following steps: (A1), selecting reference gas and introducing the reference gas into the mass spectrometer to acquire the ion signal intensity I0 corresponding to the reference gas; (A2), introducing the reference gas into the mass spectrometer in the measuring process to acquire the ion signal intensity I1 corresponding to the reference gas; and (A3), if the I1 is more than or equal to K.I0, detecting an object to be tested by using the mass spectrometer, wherein K is a set constant; and if the I1 is less than I.I0, increasing the work voltage of an ion source electrode of the mass spectrometer and the work current of a filament, continuing for a period of time and entering the step (A2). The mass spectrum ion tuning method has the advantages of high detection precision, high stability, long maintenance period, low maintenance cost and the like.

Description

Technical field [0001] The present invention relates to mass spectrometry analysis, in particular to a mass spectrometry ion tuning method. Background technique [0002] On-line mass spectrometry performs separation and detection according to different mass-to-charge ratios of different substances, and completes the quantitative analysis of the measured substances. The core part mainly includes ion source, quadrupole mass filter, detector and control module. Due to the needs of online analysis, the instrument must meet the following points: [0003] 1. Long-term stable operation, reducing manual maintenance; [0004] 2. The measured components are quantitatively accurate and have good long-term stability; [0005] currently existing problems [0006] 1. The instrument is easily contaminated, and manual cleaning is required after contamination, which increases the cost of manual maintenance; [0007] 2. The quantitative stability of trace components is poor. Summary of the invention [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/42
Inventor 张进伟郑利武任焱冯红年陈生龙顾海涛
Owner FOCUSED PHOTONICS
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