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Application of 8-propyl dicyan berberine in preparation of antitumor drug

An anti-tumor drug, the technology of berberine, applied in the field of chemical industry, can solve the problem of anti-tumor that has not been seen yet, and achieve the effect of inhibiting proliferation and inhibiting tumor.

Inactive Publication Date: 2013-06-05
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, so far, there have been no reports on the antitumor aspect of the compound

Method used

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  • Application of 8-propyl dicyan berberine in preparation of antitumor drug

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Experimental program
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Effect test

Embodiment Construction

[0017] experimental method:

[0018] 1. Cell recovery

[0019] 1) Take out the cryotube from the liquid nitrogen tank, put it directly into warm water at 37°C, and shake it from time to time to melt it as soon as possible.

[0020] 2) Take out the cryotube from the 37°C water bath, suck out the cell suspension with a pipette, pour into the centrifuge tube and add more than 10 times of culture medium, mix and centrifuge at low speed, discard the supernatant, and wash with culture medium again.

[0021] 3) After properly diluting with the culture medium, inoculate the culture bottle, place it in a 37°C incubator for static culture, replace the culture medium the next day, and continue the culture. Subculture when cultured to a certain concentration. PANC-1 cells were cultured in DMEM high-glucose medium containing 10% Gibico fetal bovine serum, SMMC-7721 and QGY cells were cultured in DMEM high-glucose medium containing 10% fetal bovine serum, and the medium contained 100U / ml ...

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Abstract

The invention belongs to the chemical industry field and the medicine field, and relates to an application of 8-propyl dicyan berberine in preparation of antitumor drugs. The invention provides the application of 8-propyl dicyan berberine in preparation of antitumor drugs, and the tumor cells comprise liver cancer cells, leukemia cells, lung adenocarcinoma cells, and pancreas cancer cells. The 8-propyl dicyan berberine belongs to a natural product, has little toxic and side effect, high bioavailability, and stable properties, and has clinical application value. The micromolecular compound of the invention can be developed as a new antitumor drug or its auxiliary component, has obvious tumor suppression effect, is green and environment-friendly, and provides a new approach and means for treating and curing tumors.

Description

technical field [0001] The invention belongs to the fields of chemical industry and medicine, and relates to the application of 8-propanedicyanoberberine in the preparation of antitumor drugs. Background technique [0002] 8-propanedicyanoberberine is an alkali derivative of 8,8-disubstituted-13,13a-dihydroberberine, and its structural formula is as follows: [0003] [0004] This compound was first reported in 1978 (The methylene signature of reduced isoquinolines: a PMR structural correlation..Heterocycles (1978), 9(2), 145-52.). In the following year, Moniot et al further described its chemical structure (Chemistry of 8-chloroberberine. Journal of Pharmaceutical Sciences (1979), 68(6), 705-8.) [0005] The Chinese invention patent application with the application number 200910049688.1 and the name "8,8-disubstituted-13,13a-dihydroberberine derivatives and their pharmaceutical compositions and uses" discloses the development of 8-propanedicyanoberberine Synthetic prep...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P35/00A61P35/02
Inventor 余龙刘祖龙胡立宏
Owner FUDAN UNIV
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