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Method for preparing oral solution of poplar flower

A poplar flower, oral liquid technology, applied in the directions of medical preparations, pharmaceutical formulations, plant raw materials, etc. containing active ingredients, to achieve good social and economic benefits, improve work efficiency and extraction rate, and reduce process water consumption.

Active Publication Date: 2014-05-07
河北康利动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with the traditional extraction method, the cellulose enzymatic hydrolysis method has the advantages of increasing the yield, saving energy, and reducing the amount of solvent used, but so far there has been no report on the use of cellulose enzymatic hydrolysis to extract poplar flowers

Method used

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  • Method for preparing oral solution of poplar flower
  • Method for preparing oral solution of poplar flower
  • Method for preparing oral solution of poplar flower

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] (1) Put 100g poplar flower into the extraction tank, add 400g water of poplar flower quality, stir and heat up to 45°C;

[0074] (2) 5g of cellulase in the extraction tank, adjust the pH value to 5.5, and enzymolyze at 45°C for 95 minutes;

[0075] (3) Filter the enzymatic hydrolysis solution, collect the filtrate, and obtain 105 mL of Yangshuhua oral solution.

[0076] The content of total flavonoids in this example was detected according to the determination method for detecting the content of total flavonoids in Yangshuhua oral liquid, and the extraction rate of total flavonoids was calculated to be 0.188%. According to the 2010 edition of "Chinese Veterinary Pharmacopoeia", the second part of Yangshuhua Oral Liquid quality standard inspection, all inspection results meet the requirements.

Embodiment 2

[0078] (1) Put 100g poplar flower into the extraction tank, add 500g water of poplar flower, stir and heat up to 45-50°C;

[0079] (2) Add 3g of cellulase to the extraction tank, adjust the pH to 5.1, and hydrolyze at 46°C for 110 minutes;

[0080] (3) Filter the enzymatic hydrolysis solution, collect the filtrate, and obtain 120 mL of Yangshuhua oral solution.

[0081] The content of total flavonoids in this example was detected according to the method for detecting the content of total flavonoids in Yangshuhua oral liquid, and the extraction rate of total flavonoids was calculated to be 0.181%. According to the 2010 edition of "Chinese Veterinary Pharmacopoeia", the second part of Yangshuhua Oral Liquid quality standard inspection, all inspection results meet the requirements.

Embodiment 3

[0083] (1) Put 100g poplar flowers into the extraction tank, add 600g water of poplar flowers, stir and heat up to 45-50°C;

[0084] (2) Add 7g of cellulase to the extraction tank, adjust the pH to 5.4, and hydrolyze at 48°C for 100 minutes;

[0085] (3) Filter the enzymatic hydrolysis solution, collect the filtrate, and obtain 130 mL of Yangshuhua oral solution.

[0086] The content of total flavonoids in this example was detected according to the method for detecting the content of total flavonoids in Yangshuhua oral liquid, and the extraction rate of total flavonoids was calculated to be 0.189%. According to the 2010 edition of "Chinese Veterinary Pharmacopoeia", the second part of Yangshuhua Oral Liquid quality standard inspection, all inspection results meet the requirements.

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Abstract

The invention discloses a method for preparing an oral solution of the poplar flower and belongs to the technical field of veterinary medicaments. The method comprises the following steps of: (1) putting the poplar flower into an extraction tank, adding water into the poplar flower, stirring, and increasing the temperature to 45-50 DEG C, wherein the water is 4-6 times of the mass of the poplar flower; (2) adding cellulose into the extraction tank, adjusting the pH value of the materials to 5.0-5.5, and hydrolyzing under the action of the cellulose for 90-120 minutes at the temperature of 45-50 DEG C, wherein the mass of the cellulose is 3-7% of that of the poplar flower; and (3) filtering a solution of enzymolysis, and collecting a filtrate to obtain the poplar-flower oral solution. The poplar flower is extracted by adopting the technology of hydrolyzing under the action of the cellulose, and a novel process for extracting the poplar flower is developed, thus the time spent in extracting the poplar flower is shortened, the heat consumption is reduced, the amount of water used in the process is reduced, and the purposes of saving energy, reducing emission, improving the work efficiency and the extraction efficiency are achieved. The method has good social and economic benefits.

Description

technical field [0001] The invention relates to the technical field of veterinary medicine, in particular to a preparation method of poplar flower oral liquid. Background technique [0002] The inflorescence of Populus populus canadensis Mench., a plant of the family Salicaceae, is rich in flavonoids, alkaloids, organic acids, vitamins, phenols and other ingredients. . Yangshuhua Oral Liquid is recorded in the 2010 edition of "Chinese Veterinary Pharmacopoeia" Part II, and it is mostly used clinically for diarrhea in pigs, sheep, and poultry. Modern pharmacological studies have shown that poplar flowers have antibacterial, antipyretic, anti-inflammatory, antidiarrheal and antidiarrheal effects. Traditional Yangshuhua oral liquid is prepared by soaking, heating and boiling, decocting, and concentration. The process takes a long time, consumes high heat energy, consumes a lot of process water, and has a low extraction rate. It takes more than ten hours to produce 1 ton of o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/76A61P31/04A61K133/00
Inventor 惠孝鑫赵凤玲冯继宗
Owner 河北康利动物药业有限公司
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