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Chronic lymphocytic leukemia (Cll) biomarkers

A biomarker, lymphocyte technology, applied in the field of biomarkers of chronic lymphocytic leukemia

Inactive Publication Date: 2013-06-12
F HOFFMANN LA ROCHE & CO AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, to date, none of these markers have shown true predictive significance for anti-CD20 antibody-based therapies in CLL

Method used

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  • Chronic lymphocytic leukemia (Cll) biomarkers
  • Chronic lymphocytic leukemia (Cll) biomarkers
  • Chronic lymphocytic leukemia (Cll) biomarkers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0246] Biomarkers to predict CLL response to CD20 antibody Materials and methods

[0247] sample:

[0248] Analysis of pretreatment patient samples from an international, multicenter, open-label phase III trial randomizing CLL patients to receive R-FC (rituximab plus fludarabine / cyclophosphamide) Or FC alone (fludarabine / cyclophosphamide). The main objective was to demonstrate better progression-free survival (PFS) of R-FC compared to FC alone. The study protocol was approved by the Institutional Review Board at the participating centers and all patients gave informed consent. Details of the trial design and eligibility criteria are described in Robak et al. J. Clin. Oncol. 28(10):1756-1765 (2010). Patients were selected for molecular genetic analysis of peripheral blood samples based on RNA availability and signed informed consent.

[0249] Pre-treatment peripheral blood mononuclear cell (PBMC) samples positively selected for CD19+ cells were available from n=301 patien...

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PUM

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Abstract

The present application describes chronic lymphocytic leukemia (CLL) biomarkers. In particular, the invention concerns miRNA151 3p, miRNA409 3p, PTK2, and / or PI3K as biomarkers for patient selection in CLL, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, and methods of advertising related thereto.

Description

[0001] related application [0002] This application claims priority under 35 USC §119 to U.S. Provisional Application No. 61 / 370,403, filed August 3, 2010, and U.S. Provisional Application No. 61 / 440,162, filed February 7, 2011, the contents of which are incorporated by reference in their entirety This article. field of invention [0003] The present invention relates to biomarkers for chronic lymphocytic leukemia (CLL). In particular, the present invention relates to miRNA1513p, miRNA4093p, PTK2, and PI3K as biomarkers for patient selection in CLL, methods of therapeutic treatment, articles of manufacture and methods for their preparation, diagnostic kits, and advertising related thereto method. Background of the invention [0004] Chronic lymphocytic leukemia (CLL) is the most common form of adult leukemia in the Western world. Like many other B-cell malignancies, CLL is characterized by the expression of the CD20 surface antigen and can thus be targeted by anti-CD20 t...

Claims

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Application Information

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IPC IPC(8): A61K39/395C07K16/28
CPCA61K39/39558A61K2039/505A61P35/02C07K2317/24C12Q1/6886C12Q2600/106C12Q2600/118C12Q2600/158C12Q2600/178G01N33/57426G01N2333/912A61K2300/00A61K39/395C07K16/28
Inventor D.多南G.杜查蒂厄-古延T.Q.古延G.帕勒莫M.维瑟R-F.叶
Owner F HOFFMANN LA ROCHE & CO AG