Laser Raman technique-based glucometer

Abstract

The invention relates to a laser Raman technique-based glucometer and relates to the field of medical detecting instruments, biological medical detection and health monitoring. The laser Raman technique-based glucometer comprises a power source, a laser source, a Raman spectral signal acquisition module, a signal processing circuit, a master control chip and a data analysis and display system. Molecular vibration and rotation structural information is obtained by the analysis on Raman scattering generated by mutual action of specific-wavelength laser and a measured object and the analysis by Raman spectral analysis technique, so that qualitative and quantitative analysis is quick, simple, repeatable and lossless. Raman spectrum of glucose molecules is well specific, fundamental frequency spectral lines are clear, and recognition is easy. Raman spectrum is non-sensitive to polar materials such as water, and interference by Raman spectrum of the water in near-infrared areas is avoided effectively. Samples need not be pretreated, and in-situ measurement is available.

Description

technical field [0001] The invention relates to the fields of medical testing instruments, biomedical testing and health monitoring, in particular to a blood glucose meter based on laser Raman technology. Background technique [0002] With the changes in people's diet structure and life rhythm and the increase of population aging, the incidence of diabetes is increasing rapidly. According to the report of "World Health Statistics 2012", one in ten people in the world suffers from diabetes, diabetes and its complications COVID-19 has become a serious public health problem all over the world. At present, there is no method to completely treat diabetes. Clinically, frequent monitoring of blood sugar concentration is mainly used to guide medication. Detection of blood sugar concentration is the key to the diagnosis and treatment of diabetes, and it is also an effective measure to prevent diabetic complications. Currently widely used blood glucose detection methods include: veno...

AI Technical Summary

Problems solved by technology

However, the use of near-infrared spectroscopy for non-invasive detection of blood sugar has the following problems: 1. The near-infrared spectrum contains the double frequency and weak combined frequency vibrations of the stretching and bending vibrations of -OH, -CH and -NH, so it has low absorption coefficient and wide bandwidth. The low selection characteristics of absorption peaks, and the diversity of -CH and -NH groups in biomolecules lead to serious overlap of spectral peaks, making spectral identification and quantitative analysis difficult; 2. Severe light scattering of near-infrared light; 3. The near-infrared absorption spectrum of water is very similar to the near-infrared absorption spectrum of glucose, so the spectral interference caused by changes in water is relatively serious

However, individual differences in body temperature and the relationship between changes in blood sugar concentration and fever have a greater impact on the test results

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