Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch

A technology of microneedle arrays and metal flakes, which is applied in the fields of medical cosmetic devices and medicine, can solve problems such as difficulty in accurate control of drug dosage and influence on curative effect, achieve good drug application effect, improve drug efficacy or beauty and beauty effects, and effectively treat The effect of time and cost performance improvement

Active Publication Date: 2015-05-20
SHANGHAI RUNTONG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the structure of the microneedle array using the metal substrate is hard and the human skin is soft, the two are not easy to be in close contact with the fitting parts of the body, which will inevitably lead to a considerable number of microneedles hanging in the air and unable to penetrate the skin. The actual dosage of transdermal administration is difficult to control accurately, which has a serious impact on the efficacy

Method used

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  • Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch
  • Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch
  • Metal micro-needle array flexible patch, transdermal applicator and transdermal application patch

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Figure 1-Figure 9 The metal microneedle array flexible patch provided by the present invention is shown, the patch includes a flexible substrate 1, and at least two are arranged at a certain distance and fixed on the surface of the flexible substrate 1 or partially embedded in the flexible substrate 1. The metal microneedle module in the flexible substrate 1, the metal microneedle module is a metal sheet 3 with protruding microneedles 2 at the edge, or a metal sheet fixed on the needle seat 4 with protruding microneedles 2 at the edge The sheet 3, or the discrete metal microneedle 2 fixed on the needle base 4, the microneedle 2 is perpendicular to the surface of the flexible substrate 1, and the tip of the microneedle 2 protrudes outward. Through the metal microneedle array flexible patch, the patch can conform to the surface of the drug application site, ensuring that the microneedles 2 can penetrate the drug application skin at the same time, and improve the effect o...

Embodiment 2

[0054] Figure 10 and Figure 9 A cross-sectional view of the structure of the transdermal drug delivery device using the metal microneedle array flexible patch provided by the present invention, the transdermal drug delivery device includes a metal microneedle array flexible patch and a base 9, and one end of the base 9 is The patch fixing surface, the other end is the handle 10 for operation, the patch fixing surface is a flat or arc-shaped curved surface, and the metal microneedle array flexible patch is permanently or detachably fixed on the patch fixing surface , or the metal microneedle array flexible patch is partially embedded in the patch fixing surface.

[0055] exist Figure 10 Among them, the metal microneedle array flexible patch is fixed on the planar patch fixing surface at one end of the base 9, and the tip structure of the microneedle 2 is different from the previous figures, specifically the tip structure with a slope.

[0056] Figure 11 Transdermal drug...

Embodiment 3

[0060] An embodiment of the present invention provides a transdermal drug delivery patch based on the metal microneedle array flexible patch, which consists of a metal microneedle array flexible patch and a transdermal patch covering it, wherein the transdermal The patches contain one or more medicinal ingredients or beauty and skin care products with therapeutic, health care or beauty care effects. Preferably, the transdermal patch is only covered on the protruding microneedles or needle tips of the metal microneedle array flexible patch, which can not only save precious medicine, but also easily control the amount of medicine entering the skin. The grooves and holes on the microneedle can not only be used to store more drugs, but also can effectively avoid the problem of drug falling out of the body during the process of piercing the skin. A variety of common physical or chemical methods such as dipping, coating, fumigation and deposition can be used to cover the transdermal...

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Abstract

The invention discloses a metal micro-needle array flexible patch, a transdermal applicator and a transdermal application patch. The metal micro-needle array flexible patch comprises a flexible substrate and at least two metal micro-needle modules which are arranged at certain intervals and fixed on the bottom surface of the flexible substrate or partially inset in the flexible substrate. Each metal micro-needle module is a metal sheet with projecting micro-needles on the edge, or a metal sheet fixed on a needle holder and provided with projecting micro-needles on the edge, or composed of metal micro-needles separately erected and fixed on a needle holder. The micro-needles are perpendicular to the surface of the flexible substrate and are hollow or solid metal micro-needles with a tip pointing out. The micro-needle array is organically combined with the flexible substrate, so that medicine is allowed to directly pass corneum to quickly enter the human body. The metal micro-needle array flexible patch is comfortable to use and evident in efficacy.

Description

technical field [0001] The invention relates to the technical fields of medical beauty equipment and medicine, in particular to a metal microneedle array flexible patch, a transdermal drug delivery device and a transdermal drug delivery patch. Background technique [0002] Transdermal drug delivery system, also known as transdermal therapeutic system, refers to a class of preparations in which drugs are absorbed through the skin through capillaries and enter the systemic circulation at a certain rate to produce drug effects. Compared with traditional drug delivery methods, transdermal drug delivery has many advantages: it can produce persistent, constant and controllable blood drug concentration, significantly improve the activity of drugs with a short half-life due to rapid metabolism in the body, and avoid the liver's first It minimizes toxic and side effects; it is painless, non-invasive or minimally invasive, and patients can take their own medicine or interrupt the medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0023
Inventor 岳瑞峰王燕
Owner SHANGHAI RUNTONG MEDICAL TECH CO LTD
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