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Modification of chitosan and chelation for heavy metal of chitosan

A chitosan modification technology, applied in other chemical processes, chemical instruments and methods, etc., can solve problems such as high viscosity, poor molecular rigidity, and lack of pertinence in the adsorption of heavy metals

Inactive Publication Date: 2013-07-17
QINGDAO AGRI UNIV
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AI Technical Summary

Problems solved by technology

[0002] Chitosan has a strong adsorption capacity for metal ions. Due to its high viscosity and poor molecular rigidity, in an acidic solution, the amino group (-NH2) in the molecule is easily protonated (-NH3 + ) and dissolved, so that its application is limited, and the adsorption of heavy metals by chitosan lacks specificity

Method used

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  • Modification of chitosan and chelation for heavy metal of chitosan

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Embodiment Construction

[0009] 1. Preparation of Modified Chitosan

[0010] Dissolve 1g of chitosan in 4.8% lactic acid solution, dilute with water, add 6g of lactose, stir and react at room temperature for 3 hours, add 1.3g of sodium cyanoborohydride, then react at room temperature for 48 hours, dialyze and freeze Dry to obtain pure modified chitosan.

[0011] 2. Detection of lactose content in modified chitosan:

[0012] The content of lactose in lactose chitosan was determined by the phenol-sulfuric acid method, measured by a spectrophotometer, a standard curve was prepared by using standard lactose, and then the content of the samples was determined, and the content of lactose was calculated by the standard curve.

[0013] 3. Preparation of lead ion imprinted lactose chitosan

[0014] The lactose chitosan and lead acetate were stirred and reacted with water for 30 minutes to make it fully activated. After activation, polyethylene glycol-10000 with a mass fraction of 1% was added, s...

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Abstract

The technical problem solved by the invention is to develop an imprinting modified chitosan with the capability of chelating heavy metal. The imprinting modified chitosan disclosed by the invention has the effect of targeting active liver and is capable of effectively removing the heavy metal in the liver. The preparation method of the imprinting modified chitosan disclosed by the invention comprises the following steps: preparing modified chitosan, optimizing reaction conditions, detecting the purity of the modified chitosan, imprinting the modified chitosan, detecting the capability of the modified chitosan for removing lead under the in-vitro condition, determining the capability of removing lead via animal experiments, determining toxicity test of the imprinting modified chitosan and acquiring the imprinting modified chitosan with the capability of chelating the heavy metal.

Description

technical field [0001] The invention relates to a preparation method of imprinted modified chitosan with the ability to chelate heavy metals, including the modification of chitosan, the imprinted modified chitosan, the detection of the ability to chelate heavy metals, and the determination of the toxicity of the imprinted modified chitosan. It is used to chelate heavy metals in the body and reduce the content of heavy metals. Background technique [0002] Chitosan has a strong adsorption capacity for metal ions. Due to its high viscosity and poor molecular rigidity, in an acidic solution, the amino group (-NH2) in the molecule is easily protonated (-NH3 + ) and dissolved, so that its application is limited, and the adsorption of heavy metals by chitosan lacks specificity. [0003] Modified chitosan is to use the hydroxyl and amino groups on the chitosan repeating unit to carry out chemical modification such as crosslinking, grafting, esterification, acylation, etherificatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/08C08J9/26C08J3/24B01J20/24B01J20/30
Inventor 赵宏坤范颖华张炜满兆红都启晶姜彦君李凤梅
Owner QINGDAO AGRI UNIV
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