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Purpose of benzo indolium containing compound LTH02 in treating multi-drug resistant bacterial infection diseases

A technology of benzindolium and compounds, applied in the field of medicine, can solve problems such as inability to kill and drug resistance of pathogenic bacteria

Inactive Publication Date: 2013-07-31
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, due to the widespread use of antibacterial drugs in clinical practice, pathogenic bacteria have developed resistance to multiple antibacterial drugs including quinolones at the same time, and even "super bacteria" that cannot be killed by existing antibacterial drugs have emerged

Method used

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  • Purpose of benzo indolium containing compound LTH02 in treating multi-drug resistant bacterial infection diseases
  • Purpose of benzo indolium containing compound LTH02 in treating multi-drug resistant bacterial infection diseases
  • Purpose of benzo indolium containing compound LTH02 in treating multi-drug resistant bacterial infection diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0011] Embodiment: antibacterial test

[0012] 1. Reagents and instruments

[0013] The iodide (10mg) of compound LTH02 is purchased from Holland Specs Company; Beef extract peptone medium is prepared by the laboratory; Gentamicin (BIOSHARP, Amresc00304); Levofloxacin (Shandong Lukang Chenxin Pharmaceutical Co., Ltd.); Analysis Pure DMSO (Nanjing Chemical Reagent Co., Ltd.), etc.; test bacteria: quinolone-sensitive Escherichia coli (gyrA is not mutated, efflux pump gene test is negative, provided by Ningbo First Hospital), quinolone-resistant Escherichia coli (Ser83Leu, Asp87Asn , efflux pump gene test was negative, provided by Ningbo First Hospital), multi-drug resistant Escherichia coli; main instruments: SW-CJ-1D single-person purification workbench, PYX-DHS water-proof electric heating constant temperature incubator, ZHWY111B Constant temperature shaker, autoclave.

[0014] 2. Preparation of compound stock solution and bacterial suspension

[0015] After weighing, LTH02...

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Abstract

The invention belongs to a field of pharmacy, and relates to a purpose of benzo indolium containing compound LTH02 in treating multi-drug resistant bacterial infection diseases. The benzo indolium containing compound LTH02 has relatively strong inhibition effect on clinically separated multi-drug resistant Escherichia coli, and can be used for researching novel and effective antibiosis medicament and treating the multi-drug resistant bacterial infection diseases. The antibiosis medicament can be prepared into tablet, pill, capsule, suspending agent, emulsion, injection or dries pulvis. The benzo indolium containing compound LTH02 has a chemical structure as shown in a formula I.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of a benzindolium-containing compound LTH02 for treating multidrug-resistant bacterial infectious diseases. Background technique [0002] Bacterial infectious disease is a common and frequently-occurring disease. It is an acute systemic infection caused by pathogenic bacteria or opportunistic pathogenic bacteria invading the blood circulation to produce toxins and other metabolites. Severe infection can even lead to septic shock. , the case fatality rate is as high as 30% to 70%. In recent years, due to the widespread clinical use of antibacterial drugs, pathogenic bacteria have developed resistance to multiple antibacterial drugs including quinolones at the same time, and even "super bacteria" that cannot be killed by existing antibacterial drugs have appeared . Infectious diseases caused by multi-drug resistant bacteria are difficult to treat, and have become the main pathoge...

Claims

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Application Information

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IPC IPC(8): C07D209/60A61K31/403A61P31/04
CPCY02A50/30
Inventor 林克江黄振桂尤启冬
Owner CHINA PHARM UNIV
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