Medical composition for treating diabetes mellitus and complications thereof

A technology for diabetes and complications, applied in the field of traditional Chinese medicine, can solve the problems of difficult control of western medicine, serious side effects and drug resistance, and achieve good results

Active Publication Date: 2015-03-25
吉林省中药制剂工程研究中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The treatment of diabetes in modern medicine mainly includes insulin secretion promoters, α-glucosidase inhibitors, growth factor antagonists, angiotensin-converting enzyme inhibitors, etc., such as insulin, biguanides, sulfonylureas, etc., but most of them have severe Side effects and drug resistance; with the prolongation of the course of diabetes, various chronic complications will appear to varying degrees, and once complications occur, it is difficult for Western medicine to control them

Method used

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  • Medical composition for treating diabetes mellitus and complications thereof
  • Medical composition for treating diabetes mellitus and complications thereof
  • Medical composition for treating diabetes mellitus and complications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Take 2500g of Coptis rhizome root, crush it, soak it with 8 times the amount of 75% ethanol, recover most of the ethanol, concentrate and place the remaining ethanol, filter, add hydrochloric acid to the filtrate to adjust the pH to 2, precipitate, place, and extract 3 times, each time for 2 hours , and the filtered yellow precipitates were combined to obtain berberine.

[0021] Take 2500g of notoginseng roots or leaves, add 10 times the amount of water to decoct three times, 1.5 hours each time, filter, combine the filtrate, concentrate, place it, take the supernatant, add it to the processed D 101 On the macroporous adsorption resin column, wash with water, then wash with 20% ethanol, and finally elute with 70% ethanol, collect the eluate, recover ethanol, concentrate, dry under reduced pressure, and refine with ethanol to obtain the total saponins of Panax notoginseng .

[0022] By weight, take 240 parts of berberine (berberine) and 60 parts of total saponins of Pan...

experiment example

[0025] 1. Effects on rat diabetic nephropathy model

[0026] After one week of adaptive feeding, the rats were randomly divided into a blank control group (10 rats) and a model group. After fasting and drinking for 12 hours, the model group was injected with streptozotocin (STZ) 50 mg / kg once through the abdominal cavity, and three days later, the fasting blood glucose was measured to be greater than 16.7 mmol / L by taking blood from the tail vein. volume of saline as a control. One week later, 50 diabetic rats whose blood sugar was still not lower than this level were randomly divided into a drug administration test group and a model group and began to administer drugs. The test was divided into six groups, and the administration group was administered intragastrically once a day. The blank control group was given distilled water 10ml / kg every day, the model control group was given distilled water 10ml / kg every day, the metformin hydrochloride group was given metformin hydro...

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Abstract

The invention provides berberine and panax notoginseng saponins and use of a composition using berberine and panax notoginseng saponins as effective components in preparing medicines for preventing and treating diabetes mellitus and complications thereof. The complications of diabetes mellitus are selected from diabetic cardiac abnormalities, diabetic renal lesions, diabetic retinopathy, diabetic peripheral neuropathy and diabetic vasculopathy.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to the application of a pharmaceutical composition of berberine (berberine) and Panax notoginseng saponins in preventing and treating diabetes and its complications. Background technique [0002] Diabetes mellitus is a metabolic disease characterized by chronically elevated blood glucose levels, caused by defects in insulin secretion and / or action. Its morbidity and mortality are increasing year by year. According to the statistics of the World Health Organization, the number of diabetic patients in the world has reached 176 million in 2000, and it is estimated that the number of patients will double to 370 million by 2030. Diabetes is not a single disease, but a syndrome caused by multiple causes. It is the result of multiple factors including genetic and environmental factors. Insulin is synthesized and secreted by pancreatic β cells, and reaches various tis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4375A61K36/258A61P3/10A61P9/00A61P13/12A61P9/10
Inventor 徐惠波温富春
Owner 吉林省中药制剂工程研究中心有限公司
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