58 results about "Renal lesion" patented technology

The invention provides berberine and panax notoginseng saponins and use of a composition using berberine and panax notoginseng saponins as effective components in preparing medicines for preventing and treating diabetes mellitus and complications thereof. The complications of diabetes mellitus are selected from diabetic cardiac abnormalities, diabetic renal lesions, diabetic retinopathy, diabetic peripheral neuropathy and diabetic vasculopathy.

The present invention provides pharmaceuticals or cosmetics, which prevent sclerotic lesions causing apoptosis, degeneration, fibrosis and atrophy, and repair and regenerate the lesions selectively, comprising a compound which preferentially increases regeneration-promoting macrophages and a method for screening the compound which preferentially increases regeneration-promoting macrophages. Pharmaceuticals or cosmetics of the present invention are useful for renal lesions, pancreatic lesions and skin lesions, because these induce regeneration-promoting immunocompetent cells lesion-selectively against organ tissue disorders and cause repair and regeneration thereof.

The invention belongs to the Chinese medicine field, in particular to a Chinese medicine for treating gout disease; the invention is characterized in that the proportion of the raw herbal materials of the invention by weight is: 15-20 parts of Chinese atractylodes, 15-18 parts of phellodendron, 15-20 parts of twotooth achyranthes root, 10-13 parts of akebiaquinata, 6-10 parts of Indian Buead peel, 8-12 parts of fourstamen stephania root, 9-13 parts of cortex lycii radicis, 10-18 parts of alismatis, 18-32 parts of semen plantaginis, and 3-8 parts of crocodile bones. The product of the invention has the functions of clearing heat, eliminating dampness, activating blood circulation, removing stagnated blood, inducing diuresis for removing edema, tonifying the kidney and nourishing the liver and removing bruise for relieving pain, can reduce serum uric acid, treat gouty arthritis, prevent the deformity caused by arthritis and prevent renal lesions, prevent urate calculi and gout calculi from being formed, and so on; thus the suffering of patients can be relieved.

The invention relates to the medicinal application of NAM, specifically to application of NAM to preparation of drugs used for preventing and treating diabetic nephropathy and regulating blood pressure, belonging to the field of compounds. The experimental results of intervention of NAM in type 2 diabetes model mice prove NAM has obvious protective effect on diabetic kidneys and can alleviate therenal fibrosis, inflammations and oxidative stress in diabetic mice, and the protection effect is achieved independent of blood sugar reduction and weight improvement. Further, NAM can be used for preparing drugs for preventing and treating diabetic nephropathy and regulating blood pressure. The application of NAM in the invention provides a novel target and a novel idea for clinical prevention and treatment of diabetic nephropathy and improvement of renal lesions, and further proves that the improvement of renal oxidative stress plays an important role in the prevention and treatment of diabetic nephropathy.

The invention discloses a renal failure early-warning method and system based on urine specific gravity and urine volume monitoring. The method includes the steps: acquiring the urine specific gravity and stepping urine monitoring indexes of different patients, and building a database; performing training on a probabilistic neural network; calculating the urine specific gravity and the stepping urine monitoring indexes of the treated patients by the aid of the trained probabilistic neural network to obtain early-warning results. According to the method and the system, the detected urine specific gravity and the detected stepping urine monitoring indexes are analyzed, the probability of renal damage can be forecasted, renal lesions is timely discovered at the early stage of renal asymptomatic damage, and effective help is provided for clinic and early treatment.

The invention discloses a structurally modified urinal set comprising at least one urinal connected with a flusher, at least one a detection sensor and at least one display device. The detection sensors disposed on the urinals are connected with the urinals. The display devices are connected with the detection sensors. Each display device is in information connection with a data base. Therefore, the urinal set can screen and detect flow volume, flow speed and ingredients of urine of a user when the user urinates; if the urine of the user fails to continuously touch the detection sensors, the display devices remind the user to see a doctor as soon as possible to prevent renal lesions, and vice versa. Therefore, each urinating record is stored through the cloud data base. The urinal set also has the practical advancement that the urinal set can be connected with a user's phone to allow for real-time diagnosis and notification for physical states.

The invention provides application of an ACAT1 gene as well as an interferent of the ACAT1 gene or protein, and a product applying the interferent, and relates to the technical field of medical engineering. According to experimental finding, the expression of the ACAT1 gene provided by the invention in the renal lesion area of a patient suffering from IgA kidney disease is sharply increased, and the kidney disease can be diagnosed through specific detection on the ACAT1 gene. Meanwhile, the interferent of the ACAT1 has the effect of inhibiting the expression of the ACAT1 gene or protein, and the interferent of the ACAT1 gene serves as a medicine and can achieve the effect of preventing and / or treating the IgA kidney disease. Therefore, the ACAT1 gene can serve as a new biomarker and can beapplied to diagnosis of the kidney disease; the corresponding interferent of the ACAT1 gene or protein can serve as a novel medicine and has potential prevention and treatment value on the IgA kidneydisease.

The invention discloses a pill for treating gout, comprising the following ingredients in parts by weight: 8-12 parts of radix aconiti preparata, 3-7 parts of rhizoma acori graminei, 2-6 parts of semen strychni, 2-12 parts of Tibetan saffron, 6-8 parts of golden cypress, 7-10 parts of akebiaquinata, 5-6 parts of radix angelicae, 3-8 parts of frankincense, 6-8 parts of myrrh, 8-10 parts of radix angelicae pubescentis, 6-8 parts of gastrodia elata, 7-12 parts of rhizoma atractylodis, 3-8 parts of pericarpium citri reticulatae and 2-8 parts of platycodon grandiflorum. The pill has the functions of clearing heat and promoting diuresis, invigorating the blood circulation to remove bruise, inducing diuresis to alleviate edema, tonifying kidney and nourishing liver, and removing the bruise to relieve pain, well reduce blood uric acid, treats gouty arthritis, prevents arthritis deformans and renal lesions, and prevents the formation of uric acid stone and tartaric disease, thus relieving the pain of a patient.

The present invention discloses a traditional Chinese medicine preparation for treating diabetic nephropathy, which is prepared from rhubarb polysaccharides, the total flavone of scutellaria root, total alkaloids of rhizoma coptis, and pharmaceutically acceptable auxiliary materials. Pharmacodynamic trials proved that the present invention has the effects of decreasing the blood glucose of the normal mouse, reducing the area under blood glucose concentration curve, and improving the sugar tolerance of the mouse; the present invention can improve the multi-food, the will drink, and the polyuriasymptoms of diabetic nephropathy model rats, reduce urinary protein and urinary albumin, decrease glycosylated hemoglobin, serum cholesterol and serum triglyceride, decrease overhigh creatinine clearance rate, reducing the renal index, alleviate the renal lesion, and have the effect for antagonizing early diabetic nephropathy. In addition, the present invention also discloses a preparation methodof the traditional Chinese medicine preparation and application in preparing a medicament for preventing and controlling diabetic nephropathy.

The invention discloses a method for preparing a kidney-tonifying product through cordyceps sinensis. The cordyceps sinensis can adjust renal functions, alleviate renal lesions of chronic diseases, improve renal functions, reduce renal damage caused by toxicants, and adjust a hematopoietic function. The kidney-tonifying product is mainly prepared from the following raw materials: the cordyceps sinensis, rhizoma dioscoreae, gordon euryale seed, eucommia bark and fructus lycii according to the formula ratio of the cordyceps sinensis to the rhizoma dioscoreae to the gordon euryale seed to the eucommia bark to the fructus lycii of (3-15):(10-25):(10-25):(10-25):(3-15); 1000g of meat is added to the raw materials; the mixture is prepared into a stewed product.

The invention provides an oral traditional Chinese medicine for treating gout and tophi. Gout refers to a group of genetically related diseases of disturbance of purine metabolism, comprises primary gout and secondary gout and has the clinical characteristics of hyperuricemia as well as gouty arthritis, tophi and renal lesions caused by hyperuricemia. Gout always occurs after liquor drinking for the first time, patients often have intense pain in toe joints at midnight, the toe joints get red, swollen and hot, great toes of 60% of the patients are under attack during first occurrence, attack can also spread to other joints, and repeated occurrence is possible. The oral traditional Chinese medicine for treating gout and the tophi comprises raw materials in parts by weight as follows: 6 parts of bulb of edible tulip, 12 parts of os sepiae, 4 parts of baking soda, 3 parts of inonotus obliquus, 5 parts of radix et rhizoma nardostachyos, 5 parts of herba lycopodii, 6 parts of scandent schefflera stem and leaf, 3 parts of radix salviae miltiorrhizae, 3 parts of radix angelicae sinensis, 4 parts of peach flower, 5 parts of radix glycyrrhizae, 5 parts of rhizoma ligustici, 3 parts of rhizoma cyperi and 3 parts of caulis cucurbitae. The invention applies to the oral traditional Chinese medicine for treating gout and the tophi.

The present invention discloses a traditional Chinese medicine preparation for treating diabetic nephropathy, which is prepared from rhubarb polysaccharides, the total flavone of scutellaria root, total alkaloids of rhizoma coptis, and pharmaceutically acceptable auxiliary materials. Pharmacodynamic trials proved that the present invention has the effects of decreasing the blood glucose of the normal mouse, reducing the area under blood glucose concentration curve, and improving the sugar tolerance of the mouse; the present invention can improve the multi-food, the will drink, and the polyuria symptoms of diabetic nephropathy model rats, reduce urinary protein and urinary albumin, decrease glycosylated hemoglobin, serum cholesterol and serum triglyceride, decrease overhigh creatinine clearance rate, reducing the renal index, alleviate the renal lesion, and have the effect for antagonizing early diabetic nephropathy. In addition, the present invention also discloses a preparation method of the traditional Chinese medicine preparation and application in preparing a medicament for preventing and controlling diabetic nephropathy.

The invention discloses a uric acid-lowering composition, which is composed of, by weight, 8-22 parts of mango, 5-14 parts of Yunnan Hovenia Thunb., 4-9 parts of cherry and 3-8 parts of Poria cocos. The composition has effects of neutralizing excessive acidic substances, regulating acid-base balance of body, promoting uric acid excretion, reducing uric acid level of serum and preventing renal lesions, metabolic diseases and cardiovascular disease caused by high uric acid content, and is suitable for those who suffer from gout, obesity, lithangiuria, ''three high''(hypertension, hyperglycemia and hyperlipemia) and the like. The preparation technology is simple and feasible, and is suitable for industrial production and market promotion and application.

Provided is a method of administering a vesicular monoamine transporter 2 (VMAT2) inhibitor to a subject in need thereof, wherein the subject has severe renal impairment.

The invention provides berberine and panax notoginseng saponins and use of a composition using berberine and panax notoginseng saponins as effective components in preparing medicines for preventing and treating diabetes mellitus and complications thereof. The complications of diabetes mellitus are selected from diabetic cardiac abnormalities, diabetic renal lesions, diabetic retinopathy, diabetic peripheral neuropathy and diabetic vasculopathy.

The invention provides application of an ACAT1 gene as well as an interferent of the ACAT1 gene or protein, and a product applying the interferent, and relates to the technical field of medical engineering. According to experimental finding, the expression of the ACAT1 gene provided by the invention in the renal lesion area of a patient suffering from IgA kidney disease is sharply increased, and the kidney disease can be diagnosed through specific detection on the ACAT1 gene. Meanwhile, the interferent of the ACAT1 has the effect of inhibiting the expression of the ACAT1 gene or protein, and the interferent of the ACAT1 gene serves as a medicine and can achieve the effect of preventing and / or treating the IgA kidney disease. Therefore, the ACAT1 gene can serve as a new biomarker and can beapplied to diagnosis of the kidney disease; the corresponding interferent of the ACAT1 gene or protein can serve as a novel medicine and has potential prevention and treatment value on the IgA kidneydisease.

The invention relates to the technical field of medical evaluation, and discloses a kidney function evaluation method and system and a storage medium. The method comprises the following steps: acquiring medical detection data of a detected object, extracting sample data, and determining key indexes related to renal functions; inputting the sample data into a machine learning model, outputting a predicted value of the key index, and defining the detection object of which the predicted value does not meet a preset range as a risk object; the method comprises the following steps: acquiring and identifying target areas of various medical image data, extracting key areas from the target areas, calculating an ability score of each key area, and screening effective areas from the key areas based on the ability scores; acquiring a target kidney image of the risk object, dividing the target kidney image into a plurality of image blocks, identifying a key area of each image block, defining the key area as a first area, matching the first area with the effective area, and evaluating the kidney lesion degree of the risk object based on a matching score. The accuracy of kidney function evaluation is improved.

The invention relates to lalang grass rhizome polysaccharide for reducing uric acid as well as a preparation method and application thereof, and relates to the field of medicines. By reducing the activity of xanthine oxidase, increasing the expression of OAT1 and OAT3 proteins in the kidney, regulating and controlling the activity of antioxidant enzymes in the body, inhibiting the release of inflammatory factors, inhibiting the generation of uric acid and reducing the level of serum uric acid, the lalang grass rhizome polysaccharide has a good treatment effect on hyperuricemia and can effectively delay the renal lesion process.

The invention discloses a berberine nano material as well as a preparation method and application thereof, and belongs to the technical field of nano materials. According to the preparation method provided by the invention, EGCG and BBR are combined with a specific nano-carrier to obtain the berberine nano-material capable of remarkably improving the water solubility of berberine and greatly improving the bioavailability of the berberine, and then the berberine nano-material can be accurately enriched at a renal lesion part through a targeted modification technology, so that the bioavailability of the berberine is greatly improved. The treatment effect on kidney diseases is enhanced, and meanwhile, the distribution of medicines in other organs is reduced, so that the side effects are reduced. The preparation method disclosed by the invention is simple and convenient, industrial production is convenient to realize, and the prepared product provides an efficient, safe and economical novel drug delivery scheme for clinical treatment of kidney diseases.

The invention discloses an application of miR-5189-5p as a medicine target point to medicines for treating diabetes and nephropathy, and particularly provides a treatment target point for potentiallytreating diabetes and renal lesions. The expression level of the miR-5189-5p is increased by a traditional Chinese medicine namely trigonelline, the expression of a target gene HIF1AN is restrained, and the restraining condition of AMPK route proteins and autophagy correlation factors in glomerular mesangium cells under high-sugar induction can be improved, so that the relative protein expressionlevel of p-AMPK, SIRT1, LC3B and Beclin-1 is increased, the expression level of P62 is reduced, the autophagy function is adjusted, and the protecting effect on glomerular mesangium cells under the high-sugar induction can be exerted. The miR-5189-5p has the beneficial effects that excessive proliferation of the glomerular mesangium cells under the high-sugar induction can be improved, the expression of the target gene HIF1AN is restrained, AMPK routes are activated, and the autophagy function is adjusted. The miR-5189-5p can be used as the medicine target point to be applied to treatment medicines for treating diabetes and nephropathy.

The invention relates to the field of medicine recipes, in particular to a traditional Chinese medicine for treating lupous nephritis. The traditional Chinese medicine is characterized by comprising the following active ingredients in parts by weight: 5-9 parts of saururus chinensis, 2-5 parts of densefruit pittany root-bark, 2-4 parts of cynanchum atratum, 5-8 parts of glabrous sarcandra herb, 5-8 parts of holly leaves, 5-8 parts of perfoliote knotweed herb, 6-9 parts of herba glechomae, 5-8 parts of dayflower, 6-9 parts of herba fibraureae recisae, 4-7 parts of centella, 2-4 parts of starjasmine stem, 2-3 parts of lycopodium clavatum, 1-3 parts of burdock, 2-4 parts of lobelia, 2-4 parts of flatstem milkvetch seed, 2-4 parts of cacumen biotae, 3-5 parts of chicory, 2-4 parts of rhizoma curculiginis, 2-4 parts of cortex acanthopanacis, 1-3 parts of epimedium, 1-3 parts of saussurea involucrate, 5-9 parts of carthamus tinctorius, 1-3 parts of semen allii tuberosi, 1-2 parts of exocarpium, 1-2 parts of sword beans and 1-2 parts of gecko. Gecko is dried in monopack and ground, water is added to soak the remaining active ingredients, residues are removed after boiling to obtain a filterate, the gecko ground in monopack is placed, and the filtrate and the gecko are mixed uniformly. The traditional Chinese medicine can effectively control lupous to act and inhibit renal lesions progress, and is effective to lupous nephritis in early and later periods.

The invention discloses a traditional She medicine containing traditional Chinese medicine prescription for patients suffering from blood stasis syndromes of high blood pressure accompanied with target organ damage. The traditional She medicine containing traditional Chinese medicine prescription for patients suffering from blood stasis syndromes of high blood pressure accompanied with target organ damage is characterized by comprising the following components in parts by weight of 5-15 parts of Shiliangcha, 10-15 parts of Gagoulu, 25-35 parts of radix salviae miltiorrhizae, 10-20 parts of tree peony bark, 25-35 parts of dry motherwort, 10-15 parts of radix paeoniae rubra, 6-13 parts of rhizoma gastrodiae, 10-20 parts of ramuli umcariae cum uncis, 10-20 parts of grassleaf sweetflag rhizomes, 10-20 parts of radix cyathulae and 1-2 parts of scalded leech powder. For patients suffering from ventricular hypertrophy, 15-25 parts of radix astragali and 10-20 parts of raw haws are added; forpatients suffering from renal damage, 10-20 parts of prepared rhizoma polygonati and 25-35 parts of centella are added; and for patients suffering from carotid artery damage, 25-35 parts of radix puerariae is added.

The present invention relates to a method of identification and quantification of proteins, isoforms of angiotensin I converting enzymes (ACE), 190-kDa, specially of 90kDa in tissues, cells and biological fluids, specially in urine, genetic marker and prognostic agent of hypertension and primary or secondary renal lesion and kit for using in the diagnosis, risk stratification and therapeutical decision in arterial hypertension. One the aims of the present invention is to check the potential of the 90 kDa isoform as a hypertension genetic marker isoform and as a prognostic for hypertension.

The present invention discloses a method and system for guiding the planning of ablation of a renal lesion, which relates to the technical field of ablation guidance planning. The method and system for guiding the planning of ablation of a renal lesion include the following specific steps: acquiring the anatomical structure of the kidney based on image acquisition, extracting key features from the acquired multi-source images, extracting and identifying the edge of the tumor, identifying the edge of the tumor based on the acquired key features, and generating an optimal ablation path that avoids the key structure. The present invention acquires the anatomical structure of the kidney through multiple CT and ICE images to reduce the error in identifying the boundary of the tumor, and aligns the multi-source images based on a deformation field algorithm to further improve the accuracy of identifying the boundary of the tumor. In the actual ablation process, the multi-source images are fused with an electromagnetic sensor to monitor the deviation of the ablation needle tip.

The invention discloses a kidney sclerosis proportion analysis method and system based on an MRI image, and belongs to the technical field of medical image processing, and the method comprises the steps: carrying out the MRI imaging sequence selection according to the kidney lesion characteristics of a patient; performing image acquisition on the kidney of the patient based on the MRI imaging sequence to obtain different MRI imaging sequence images; the MRI imaging sequence images are fused, and a multi-modal image is obtained; preprocessing the multi-modal image, wherein the preprocessing comprises pixel-by-pixel signal intensity correction, histogram equalization, adaptive filtering and non-local mean denoising; carrying out image segmentation on the preprocessed multi-modal image to obtain a binary image comprising a hardened region and a normal region; and obtaining the kidney sclerosis proportion based on the binary image. According to the method, the recognition accuracy and the quantification precision of the kidney sclerosis area can be improved, the kidney sclerosis degree can be evaluated more accurately, powerful support is provided for clinical research, and the medical level is improved.

The invention relates to a deep learning-based type-2 diabetes renal lesion image classification method; aiming at the urgent demand of intelligent classification and statistics of diabetes renal lesion, the method comprises the following steps: acquiring a renal lesion image of a diabetic patient, and carrying out pre-processing such as marking and normalization on the renal lesion image of the diabetic patient; processing the renal lesion image of the diabetic patient by using a neural network method, automatically detecting the renal lesion category of the diabetic patient, and outputting a detection result. The invention can assist doctors in diagnosis of lesion recognition of the diabetic kidney, greatly improves the recognition efficiency, is particularly suitable for large-scale recognition, screening and statistics of the diabetic kidney lesion, helps to reduce the working pressure and burden of inspection personnel, reduces the consumption of human resources, and the invention can better serve areas with shortage of medical resources.

The invention provides an application of alkannic acid in preparation of a medicine for treating lupus nephritis, the structural formula of the alkannic acid is as shown in the specification, and the invention also provides an application of the alkannic acid in preparation of a medicine for reducing kidney macrophage infiltration caused by lupus nephritis. Experiments find that alkannic acid can reduce expression of lupus autoantibodies and cytokines, reduce macrophage infiltration and deposition of immune globulin and the like, a new method is provided for treating lupus nephritis, and the problem of innate immune cell infiltration of lupus nephritis, which is a therapeutic drug participating in an important process of renal lesion, is effectively solved.

This invention discloses an 8–18 nm covalently bonded pH-responsive biomass active pharmaceutical ingredient (API), its preparation method, and its applications. The API has a three-layer covalently bonded core-shell structure, is free of free small molecules, and exhibits excellent structural stability. It is prepared from bamboo-derived biomass raw materials such as modified bile acid-bamboo flavonoid cocrystal complex, modified bamboo polysaccharides, and galactose oligosaccharides. The product has a particle size of 8–18 nm, a PDI < 0.21, a Zeta potential of -8.0 to -11.0 mV, and possesses pH-targeted drug release characteristics within the renal lesion microenvironment. Under normal physiological conditions, the drug leakage rate is less than 3.2%, and the in vivo biodegradation rate exceeds 99.1% within 72 hours. It exhibits no tissue accumulation and high safety. This invention targets the common pathological features of renal oxidative stress, chronic inflammation, and immune dysregulation in viral renal failure and renal cancer, exerting therapeutic effects through antioxidant, anti-inflammatory, renal tubular barrier repair, and immune regulation mechanisms. This invention employs a room-temperature pure aqueous phase reaction combined with a two-stage ultrafiltration process, ensuring mild conditions, batch stability, and suitability for industrial mass production.