Praziquantel-mebendazole nanoemulsion oral liquid and preparation method thereof
A technology of mebendazole and oral emulsion, applied in the field of medicine, can solve the problems of poor bioavailability and water insolubility, and achieve the effects of improving anticorrosion performance, high thermodynamic stability and improving bioavailability
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Embodiment 1
[0034] Accurately weigh 30.00g of Tween-80, 15.23g of ethanol, 15.00g of ethyl acetate, and 15.15g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 1.5g of praziquantel and 1.5g of mebendazole directly, stir thoroughly, then slowly add distilled water to it, and stir manually while adding distilled water. Add dropwise and keep stirring. When the system suddenly becomes thinner, a stable pale yellow transparent praziquantel-mesbendazole nanoemulsion oral liquid is produced, and its total weight is 100.0g.
Embodiment 2
[0036] Accurately weigh 30.00g of Tween-80, 24.00g of ethanol, 15.00g of ethyl acetate, and 18.00g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 0.1g of praziquantel and 0.1g of mebendazole directly, stir until they are completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will change. Viscous, continue to drop and stir continuously, when the system suddenly becomes thinner, what is produced at this time is a stable light yellow transparent praziquantel-Mbz nanoemulsion oral liquid, which is said to have a total weight of 100.0g.
Embodiment 3
[0038] Accurately weigh 21.00g of Tween-80, 21.00g of ethanol, 7.00g of ethyl acetate, and 7.00g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 0.2g of praziquantel and 0.2g of mebendazole directly, stir until they are completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will change. Viscous, continue to drop and stir continuously, when the system suddenly becomes thinner, what is produced at this time is a stable light yellow transparent praziquantel-Mbz nanoemulsion oral liquid, which is said to have a total weight of 100.0g.
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