Praziquantel-mebendazole nanoemulsion oral liquid and preparation method thereof

A technology of mebendazole and oral emulsion, applied in the field of medicine, can solve the problems of poor bioavailability and water insolubility, and achieve the effects of improving anticorrosion performance, high thermodynamic stability and improving bioavailability

Active Publication Date: 2015-03-04
张晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the disadvantages of being insoluble in water and having poor bioavailability

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Accurately weigh 30.00g of Tween-80, 15.23g of ethanol, 15.00g of ethyl acetate, and 15.15g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 1.5g of praziquantel and 1.5g of mebendazole directly, stir thoroughly, then slowly add distilled water to it, and stir manually while adding distilled water. Add dropwise and keep stirring. When the system suddenly becomes thinner, a stable pale yellow transparent praziquantel-mesbendazole nanoemulsion oral liquid is produced, and its total weight is 100.0g.

Embodiment 2

[0036] Accurately weigh 30.00g of Tween-80, 24.00g of ethanol, 15.00g of ethyl acetate, and 18.00g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 0.1g of praziquantel and 0.1g of mebendazole directly, stir until they are completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will change. Viscous, continue to drop and stir continuously, when the system suddenly becomes thinner, what is produced at this time is a stable light yellow transparent praziquantel-Mbz nanoemulsion oral liquid, which is said to have a total weight of 100.0g.

Embodiment 3

[0038] Accurately weigh 21.00g of Tween-80, 21.00g of ethanol, 7.00g of ethyl acetate, and 7.00g of N,N-dimethylacetamide, put them into a beaker, and mix them thoroughly by manual stirring at room temperature of 20°C. Add 0.2g of praziquantel and 0.2g of mebendazole directly, stir until they are completely dissolved, then slowly add distilled water to it, and stir manually while adding distilled water. At the beginning, the viscosity of the system is small. As the amount of distilled water increases, the system will change. Viscous, continue to drop and stir continuously, when the system suddenly becomes thinner, what is produced at this time is a stable light yellow transparent praziquantel-Mbz nanoemulsion oral liquid, which is said to have a total weight of 100.0g.

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PUM

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Abstract

A praziquantel-mebendazole nanoemulsion oral liquid medication, the diameter of the droplets thereof being between 10 nm and 100 nm, and the nanoemulsion being made from raw materials in the following percentage by weight: 15.00%-30.00% of a surfactant, 15.23%-24.00% of a cosurfactant, 5.00%-15.00% of ethyl acetate, 5.00%-18.00% of N,N-dimethylacetamide, 0.10%-1.50% of praziquantel, 0.10%-1.50% of mebendazole and 5.80%-53.40% of distilled water, the sum of the components being 100%.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a new dosage form of praziquantel-mesbendazole, in particular to a transparent and stable praziquantel-mesbendazole nanoemulsion oral liquid. Background technique [0002] Parasitic diseases are common zoonotic diseases, and the development of new drugs to treat animal parasitic diseases plays an important role in ensuring the overall health of human beings and promoting the development of animal husbandry. [0003] Praziquantel is a broad-spectrum antiparasitic drug. It has a wide anti-helminth spectrum, and it also has killing effects on Schistosoma japonicum, Schistosoma haematobium, Schistosoma mansoni, paragonimiasis, clonorchis sinensis, hydatid, cysticercosis, sparganosis, fasciola zingiberi, tapeworm, etc. Since its inception, it has been widely used in the treatment and control of schistosomiasis due to its advantages of high efficiency, low toxicity and low price. Praziquantel ha...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4985A61K9/107A61K47/10A61K47/34A61K47/14A61P33/10A61K31/4184
CPCA61K47/14A61K9/107A61K47/10A61K31/4985A61K47/34A61K31/4184A61K9/1075A61K47/26A61P33/10A61K2300/00
Inventor 张晓燕
Owner 张晓燕
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