A biochip based on grating guided mode resonance technology and its preparation method
A guided mode resonance, biochip technology, applied in measurement devices, phase influence characteristic measurement, instruments, etc., can solve the problems of unfavorable commercialization, large size and complex structure of biochips, and reduce blood extraction and heat generation. Tiny, volume-reducing effect
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[0032] A biochip based on grating guided mode resonance technology (see attached figure 1 ), which includes a base layer 1, the upper surface of the base layer 1 is a titanium thin film layer 2, and the upper surface of the titanium thin film layer 2 is a grating waveguide layer.
[0033] The base layer 1 is quartz or glass.
[0034] The grating waveguide layer includes titanium dioxide medium 3 and low refractive index organic medium 4 , and the low refractive index organic medium 4 is filled between the titanium dioxide medium 3 .
[0035] The refractive index of the low-refractive-index organic medium 4 is 1.40-1.60, and the low-refractive-index organic medium 4 is polymethyl methacrylate PMMA film, polydimethylsiloxane PDMS film, polyacrylate film, or poly A mixture film composed of methyl methacrylate PMMA film, polydimethylsiloxane PDMS film, polyacrylate film and silane coupling agent.
[0036] The silane coupling agent is γ-glycidoxypropyltrimethoxysilane or γ-metha...
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