A biochip based on grating guided mode resonance technology and its preparation method

A guided mode resonance, biochip technology, applied in measurement devices, phase influence characteristic measurement, instruments, etc., can solve the problems of unfavorable commercialization, large size and complex structure of biochips, and reduce blood extraction and heat generation. Tiny, volume-reducing effect

Active Publication Date: 2016-02-17
贵州中孚科技有限公司
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Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a biochip based on grating guided mode resonance technology and its preparation method, so as to solve the problem of large volume, high cost and complex structure of the biochip in the prior art. Although small in size and cheap in price, there are problems such as temperature compensation shortcomings

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  • A biochip based on grating guided mode resonance technology and its preparation method
  • A biochip based on grating guided mode resonance technology and its preparation method
  • A biochip based on grating guided mode resonance technology and its preparation method

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Embodiment

[0032] A biochip based on grating guided mode resonance technology (see attached figure 1 ), which includes a base layer 1, the upper surface of the base layer 1 is a titanium thin film layer 2, and the upper surface of the titanium thin film layer 2 is a grating waveguide layer.

[0033] The base layer 1 is quartz or glass.

[0034] The grating waveguide layer includes titanium dioxide medium 3 and low refractive index organic medium 4 , and the low refractive index organic medium 4 is filled between the titanium dioxide medium 3 .

[0035] The refractive index of the low-refractive-index organic medium 4 is 1.40-1.60, and the low-refractive-index organic medium 4 is polymethyl methacrylate PMMA film, polydimethylsiloxane PDMS film, polyacrylate film, or poly A mixture film composed of methyl methacrylate PMMA film, polydimethylsiloxane PDMS film, polyacrylate film and silane coupling agent.

[0036] The silane coupling agent is γ-glycidoxypropyltrimethoxysilane or γ-metha...

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Abstract

The invention discloses a biochip based on grating guided mode resonance technology and a preparation method thereof, which comprises a base layer (1), the upper surface of the base layer (1) is a titanium thin film layer (2), and the titanium thin film layer (2) The upper surface of the upper surface is a grating waveguide layer; the preparation method includes step 1, base layer coating, coating a titanium thin film layer (2) on the selected base layer (1); step 2, cleaning, cleaning the coated base Clean; step 3, grating processing, processing the base base cleaned in step 2 into a periodic grating of titanium dioxide and air in the array; step 4, cleaning the base base of the grating processed in step 3; step 5, processing step 4 The base of a good grating is chemically plated with a low-refractive-index organic medium; it solves the problems of large volume, high cost, and complex structure in the existing biochips, which do not use commercialization or are small in size and cheap in price. Problems such as temperature compensation shortcomings.

Description

technical field [0001] The invention belongs to biochip technology, in particular to a biochip based on grating guided mode resonance technology and a preparation method thereof. Background technique [0002] Current scientific research has found that in different stages of the disease, even in the early stage of the disease without any symptoms, the protein level in human body fluids has changed, which in turn affects the functions of organs, tissues and organisms, manifested as the occurrence of clinical diseases, Rapid and effective detection of protein levels in human body fluids is of great significance for the prevention, diagnosis and treatment of diseases. In addition, the traditional biochemical analysis technology requires complex procedures to detect protein levels, which is time-consuming and cannot achieve non-destructive testing. At the same time, it also brings great pain to the patient's body and mind, and increases the financial burden of the patient. [00...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/41G01N33/577
Inventor 白忠臣肖伟秦水介张正平
Owner 贵州中孚科技有限公司
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