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Application of lycojaponicumin C in the preparation of drugs for treating lung cancer

A drug, lung cancer technology, applied in the field of anti-tumor drugs, can solve problems such as damage to normal tissues and cells, and achieve the effect of highlighting substantive characteristics

Active Publication Date: 2015-12-02
安徽网萌科技发展股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application.

Method used

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  • Application of lycojaponicumin C in the preparation of drugs for treating lung cancer
  • Application of lycojaponicumin C in the preparation of drugs for treating lung cancer
  • Application of lycojaponicumin C in the preparation of drugs for treating lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Embodiment 1: the preparation of the compound LycojaponicuminC tablet involved in the present invention:

[0013] Take 20 grams of compound Lycojaponicumin C, add 180 grams of conventional excipients for tablet preparation, mix well, and make 1000 tablets with a conventional tablet press.

Embodiment 2

[0014] Embodiment 2: the preparation of compound LycojaponicuminC capsules involved in the present invention:

[0015] Get 20 grams of compound Lycojaponicumin C, add conventional adjuvants such as starch 180 grams for preparing capsules, mix well, pack into capsules and make 1000 tablets.

[0016] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example

[0017] Experimental Example: LycojaponicuminC's Inhibitory Effect on the Proliferation of Lung Cancer Cells Cultured in Vitro and its Effect on Human Normal Cells

[0018] Take the lung cancer cells in the logarithmic growth phase (non-small cell lung cancer cell A 549 , large cell lung cancer cells NCI-H460, lung squamous cell carcinoma cells HTB-8, human lung squamous cell carcinoma cells QG-5) and human normal liver cells L02 were inoculated on 96-well culture plates, and the seeding volume per well was 3000-4000 cells / 100uL and 6000 cells / 100uL; aseptically collect 15mL of venous blood from healthy blood donors, anticoagulate with heparin, separate mononuclear cells by Ficoll density gradient centrifugation, prepare single cell suspension with RPMI1640 containing 10% fetal bovine serum, adjust Cell concentration was 2 x 10 5 cells / mL, inoculated in 96-well culture plate, 100uL per well. After 24 hours of cell culture on the above-mentioned culture plates, the experimenta...

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Abstract

The invention discloses an application of Lycojaponicumin C in the preparation of medicines for treating lung cancer. The compound shows good anti-lung cancer activity, can be used for the preparation of anti-lung cancer medicines and belongs to the technical field of new applications of medicines. The Lycojaponicumin C can be used for obviously inhibiting a non-small cell lung cancer cell A549, a large-cell lung cancer cell NCI-H460, a lung squamous carcinoma cell HTB-8 and a human lung epidermoid carcinoma cell QG-5 which are cultured in vitro, has a low inhibition effect on a human normal lung cell LO2 and a peripheral blood lymphocyte and shows up obvious selectivity. The application of the Lycojaponicumin C in the preparation of the medicines for treating the lung cancer is disclosed for the first time. As the skeleton type of the Lycojaponicumin C belongs to a brand-new skeleton type, the Lycojaponicumin C has unexpected strong inhibitory activity on the lung cancer cells.

Description

technical field [0001] The invention relates to the field of antitumor drugs, in particular to the application of LycojaponicuminC in the preparation of antitumor drugs. Background technique [0002] Malignant tumors are diseases that seriously threaten human life and health. Chemotherapy drugs commonly used in clinical practice can greatly damage normal tissues and cells while killing tumor cells, which limits its application. It has become the direction and urgent task of current anticancer drug research to find highly efficient and low toxic drugs for treating tumors. Finding high-efficiency, low-toxic anticancer drugs has been considered an effective way. [0003] The present invention has confirmed by experiment that LycojaponicuminC has the effect on non-small cell lung cancer cell A cultured in vitro. 549 , large cell lung cancer cell line NCI-H460, lung squamous cell carcinoma cell line HTB-8 and human lung squamous epithelial cell line QG-5 have significant inhibi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/438A61P35/00
Inventor 张红丽
Owner 安徽网萌科技发展股份有限公司
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