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Process for preparing rhodiola rosea extract with high antioxidant value using ultrafiltration method

A technology of oxidation value and Rhodiola rosea, which is applied in the direction of medical preparations containing active ingredients, anti-toxins, drug combinations, etc., and can solve the problems of limited application and anti-oxidation value that cannot meet the medicinal needs

Active Publication Date: 2014-01-15
NINGBO BEILUN EXCARE PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, according to the current extraction process, the antioxidant value of Rhodiola rosea extract cannot meet the medicinal needs, which limits its application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 1 kg of Rhodiola rosea raw material, dry it, the content of salidroside is 0.45%, and the content of rosavir is 1.05%. Pulverize with a traditional Chinese medicine pulverizer and pass through a 10-mesh sieve. At 50°C, 8L of 60% ethanol was used as the extraction solution, and the extraction was performed twice, and the extraction time was 3 hours each time, and the solid-liquid ratio was 1:8. The extract is filtered through a 100-mesh sieve, concentrated until the alcohol content of the concentrate is 5 degrees, and adsorbed to saturation by macroporous resin D101. Use 2 times column volume of 30% ethanol to elute first to remove less polar impurities, then use 3 times column volume to extract 80% ethanol for elution, and collect the eluate. The eluate is first filtered with a 0.45μm microporous membrane to remove tiny particles, then filtered through a 5nm ceramic membrane to remove impurities with a relative molecular weight above 100,000, and finally filtered ...

Embodiment 2

[0027] Take 1 kg of Rhodiola grandiflora as raw material, dry it, the content of salidroside is 0.75%, and the content of rosavir is 0.32%. Pulverize with a traditional Chinese medicine pulverizer and pass through a 10-mesh sieve. At 50°C, 8L of 60% ethanol was used as the extraction solution, and the extraction was performed twice, and the extraction time was 3 hours each time, and the solid-liquid ratio was 1:8. The extract is filtered through a 100-mesh sieve, concentrated until the alcohol content of the concentrate is 5 degrees, and adsorbed to saturation by macroporous resin D101. Use 2 times column volume of 30% ethanol to elute first to remove less polar impurities, then use 3 times column volume to extract 80% ethanol for elution, and collect the eluate. The eluate is first filtered with a 0.45μm microporous membrane to remove tiny particles, then filtered through a 5nm ceramic membrane to remove impurities with a relative molecular weight above 100,000, and finally ...

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Abstract

The invention relates to a process for preparing a rhodiola rosea extract with a high antioxidant value using the ultrafiltration method. The process comprises the following steps: (1) drying and crushing rhodiola rosea material to obtain crude powder, extracting with an ethanol solution, and then filtering and concentrating to obtain a concentrate; (2) adsorbing the concentrate via macroporous adsorbent resin, preparing elution solvents, eluting the resin with the solvents respectively, and collecting the eluates; (3) performing step-by-step membrane filtration on the eluates to obtain a target solution; (4) concentrating the target solution and then drying by the freeze-drying method, and producing the rhodiola rosea extract with a high antioxidant value. With adoption of the combination of the membrane filtration method and the freeze-drying method, a high content of rhodiola rosea extract with a high antioxidant value is obtained, and the rosavin content of the rhodiola rosea extract obtained by the method is 5-25%, the salidroside content is 5-20%, and the antioxidant value is 1000-2000 mumole TE / g.

Description

technical field [0001] The invention belongs to the field of preparation of Rhodiola rosea extract, in particular to a method for producing Rhodiola rosea extract with high antioxidant value by ultrafiltration. Background technique [0002] Rhodiola rosea (Rhodio Larosea) is the root and rhizome of Crassu Laceae (Crassu Laceae) Sedum genus (Rhodio La) plants. my country is the distribution center of Rhodiola, and more than 70 of the more than 90 species of Rhodiola in the world are distributed in my country. Southwest regions such as Sichuan, Tibet, and Yunnan are the main producing areas of Rhodio Lacrenuata (Hook.f.et Thomx.) H.Ohba, and Tibet has the largest output. [0003] There are many reports on the chemical components of Rhodiola daflora, such as: Bao Wenfang, Wu Weichun, Li Baohua. The anti-fatigue medicinal plant Rhodiola rosea [M]. People's Military Medical Press, 2003: 1-2, reported that Dahuahong Sedum mainly contains alcohols and their glycosides, flavonoids...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/41A61P39/06
Inventor 方燕李红李杲许阳史冬燕
Owner NINGBO BEILUN EXCARE PHARMA TECH
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