A kind of pharmaceutical composition for treating cancer and its application

A composition and drug technology, applied in the field of pharmaceutical compositions for the treatment of cancer, can solve problems such as the lack of effective treatment drugs for peripheral neuropathy, and achieve the effects of delaying chronic cumulative neurotoxicity, no adverse reactions, and good patient compliance

Active Publication Date: 2015-11-25
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is currently no effective treatment for peripheral neuropathy caused by oxaliplatin

Method used

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  • A kind of pharmaceutical composition for treating cancer and its application
  • A kind of pharmaceutical composition for treating cancer and its application
  • A kind of pharmaceutical composition for treating cancer and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] Example 1: Study on the protective effect of herbal composition AC591 on oxaliplatin-induced peripheral neuropathy in rats.

[0063] 1. Experimental materials

[0064] Experimental drug: Oxaliplatin (Aiheng) injection (50 mg, batch number 1103211), purchased from Jiangsu Hengrui Medicine Co., Ltd.

[0065] Instruments: Vonfreyhairs pain tactile test kit (Stoelting, USA), Leica RM2135 rotary tissue slicer (Germany), ABI7500 fluorescent quantitative PCR instrument (ABI, USA).

[0066] Experimental animals: male WISTAR rats, weighing 180-200g, clean grade, purchased from Shanghai Slack Experimental Animal Center, and kept in the SPF-level experimental animal room of Jiangsu Institute of Traditional Chinese Medicine. The experimental temperature was controlled at 25±1°C, the lights were controlled for 12 hours of light and 12 hours of darkness, free drinking water and animal feed. The experiment was started after 7 days of feeding.

[0067] Preparation of oxaliplatin solut...

Embodiment 2

[0093] Example 2: Clinical observation of herbal composition AC591 in treating peripheral neurotoxicity induced by oxaliplatin.

[0094] 1. Clinical data:

[0095] There are 48 groups in this group, 30 males and 18 females, aged 30-70 years, with an average age of 52.5 years; 32 cases of colon cancer and 16 cases of rectal cancer. They were randomly divided into a treatment group of 24 cases and a control group of 24 cases. There was no significant difference in gender, age, and condition between the two groups (p>0.05), which were comparable. Inclusion criteria: ①Patients with clear cytological or pathological basis for diagnosis of colorectal cancer; ②All suitable for chemotherapy containing oxaliplatin; ③Kamofsky score>60 points; ④Blood routine, liver and kidney function, heart and lung function Normal; ⑤Estimated survival time > 3 months; ⑥Sign informed consent; ⑦Good compliance, obey doctor's arrangement, and accept doctor's follow-up. Exclusion criteria: ①Patients with...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for treating cancer, which includes: (1) herbal compositions derived from astragalus, cassia twig, peony, jujube and ginger or extracts of the above mixed herbal medicines; (2) one or more A chemotherapeutic compound. The invention also discloses the application of the above pharmaceutical composition in preparing drugs for treating human cancer and in preparing drugs for reducing the side effects of chemotherapy compounds in the human body. The pharmaceutical composition of the present invention can reduce peripheral neuropathy side effects caused by chemotherapy drugs, such as limb paresthesia, pain, cold skin, ant walking sensation, weakness in holding objects, etc., increase the limit of anti-cancer drugs, and enhance the efficacy of anti-cancer drugs.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating cancer and its application, belonging to the technical field of Chinese herbal medicine. Background technique [0002] In recent years, malignant tumors have become the second cause of death after cardiovascular and cerebrovascular diseases [1] . Currently, the main treatment methods for malignant tumors include surgery, radiotherapy and chemotherapy. Among them, chemotherapy acts on different links of tumor cell proliferation through drugs, thereby inhibiting or killing tumor cells, and has become an indispensable and important means in tumor treatment. Chemotherapy-induced peripheral neuropathy (CIPN) is one of the common side effects among the adverse reactions of anti-tumor chemotherapy drugs, mainly manifested as symmetrical numbness of fingers and toes, mechanical or cold-induced abnormalities Pain, progressive burning pain, myalgia, tingling and other symptoms. CIPN widely ex...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P35/00A61K33/24A61K31/475A61K31/337A61K31/282
CPCA61K36/9068A61K31/555A61K36/481A61K36/54A61K36/65A61K36/725A61P35/00A61K2300/00
Inventor 曹鹏成小兰霍介格王小宁胡镜清蔡雪婷杨洋胡春萍魏国立
Owner LUNAN PHARMA GROUP CORPORATION
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