New application of bis(α-furanoic acid)vanadyl as an anticancer drug

A technology of furancarboxylic acid and anti-lung cancer drugs, which is applied in the field of medicine and can solve the problems of aggravating drug side effects, failure of chemotherapy, and increased dosage of drugs

Inactive Publication Date: 2015-08-12
KUNMING INST OF PRECIOUS METALS +2
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Problems solved by technology

During chemotherapy, cancer cells are insensitive to previously used platinum drugs and develop drug resistance, and the generation of drug resistance seriously reduces the efficacy of drugs, leading to an increase in the dosage of drugs, which in turn aggravates the side effects of drugs , resulting in the failure of chemotherapy

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  • New application of bis(α-furanoic acid)vanadyl as an anticancer drug
  • New application of bis(α-furanoic acid)vanadyl as an anticancer drug
  • New application of bis(α-furanoic acid)vanadyl as an anticancer drug

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Embodiment Construction

[0013] The present invention will be further described below in conjunction with accompanying drawing and specific embodiment

[0014] (1) Synthesis of bis(α-furanoic acid)vanadyl (BFOV)

[0015] In the literature [Xie Mingjin, Liu Weiping, Li Ling, Chen Zhihe. Synthesis and antidiabetic activity of bis(α-furanoic acid)vanadyl. Chemical Journal, 2002, 60 (5): 892-896] on the basis of the laboratory preparation method reported, through optimization and improvement, obtain such as figure 1 The batch synthesis technique shown. Weigh 22.4 g, 0.2 mol) of a-furancarboxylic acid, dissolve it in 150 ml of water, add barium carbonate (19.7 g, 0.1 mol), and react at 45°C for 5 h to obtain a colorless clear solution (1). Accurately take the reserve 1.0 mol / L VOSO 4 Solution 101ml (equivalent to 0.101mol) is mixed with the above solution at room temperature and stirred until no free barium ions are detected with sodium sulfate. This reaction generally takes 3-4 hours. Filte...

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Abstract

The invention relates to a novel use of a vanadium complex-bis(α-furanoic acid)vanadyl as an anticancer drug. Vanadium is an essential trace element for the human body. Bis(α-furanoic acid) vanadyl is a vanadyl complex with the metabolite α-furanic acid of furfural in the human body as a ligand. It is a potential antidiabetic drug. Studies have found that α-furancarboxylic acid has a strong killing effect on cancer cells, and its IC50 is less than or equivalent to cisplatin. It has stronger activity on cancer cells resistant to cisplatin, and its toxicity to normal human cells is less than that of Cisplatin has less acute toxicity to mice than cisplatin. In addition, it has high water solubility and good stability in aqueous solution. Therefore, bis(α-furanoic acid)vanadyl can be used as an anticancer drug for the treatment of malignant tumors.

Description

technical field [0001] The invention relates to a novel use of a vanadium complex-bis(α-furanoic acid)vanadyl as an anticancer drug, and belongs to the technical field of medicine. Background technique [0002] Malignant cell tumors have always been a major disease that threatens human health and life. At present, clinical treatment mainly relies on three major methods, namely surgery, radiotherapy and chemotherapy, but the therapeutic effect is still very limited [Han Rui, Sun Yan. New Chemoprevention and drug treatment of cancer in the century. People's Military Medical Publishing House, Beijing: 2006, 3-11]. The basis of chemotherapy is anticancer drugs. Among more than 70 commonly used anticancer drugs, platinum drugs represented by the following cisplatin structural formula occupy an important position and have been widely used in lung cancer, ovarian cancer, colon cancer and other common First-line treatment of tumors, accounting for about 50% of all cancer chemothera...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/555A61P35/00
Inventor 刘伟平李艳李玲谌喜珠周宏宇高丽辉张静姜婧
Owner KUNMING INST OF PRECIOUS METALS
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