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Liuwei Anxiao pharmaceutical composition and application of preparation thereof in preparation of drug for treating alcoholic hepatitis

A technology of alcoholic hepatitis and Liuwei Anxiao, which is applied in the field of medicine, can solve problems such as no research reports on the composition of Liuwei Anxiao, and achieve remarkable curative effect and wide clinical application

Active Publication Date: 2014-02-26
JINKE TIBETAN MEDICINE QINGHAI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are no relevant research reports on the application of Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of drugs for the treatment of alcoholic hepatitis in the above patents and literature

Method used

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  • Liuwei Anxiao pharmaceutical composition and application of preparation thereof in preparation of drug for treating alcoholic hepatitis

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1、 6

[0023] Experimental example 1. Preparation of Liuwei Anxiao pharmaceutical composition and its preparation

[0024] 1. Prescription: 75g of Tibetan wood incense, 300g of rhubarb, 150g of kaempferi, 375g of calcined northern cold water stone, 225g of myrobalan, 450g of alkali flower;

[0025] 2. Active ingredient preparation

[0026] (1) According to the composition of the raw material medicine, take the four medicinal materials of Zangmuxiang, Rhubarb, Shantou, and Myrobalan, and extract twice with 70% ethanol at reflux, each extraction time is 2 hours, and the solvent dosage is 10% of the weight of the medicinal material. Double the volume and filter to obtain drug residue A and extract A, extract A under reduced pressure to recover ethanol, concentrate, and dry to obtain extract A;

[0027] (2) The step (1) obtained by step (1) is the alkali flower composed of drug residue A and the raw material drug, and the calcined Beihan water stone composed of half of the raw material drug is d...

experiment example 2

[0033] Experimental example 2. Clinical observation on treatment of alcoholic hepatitis

[0034] In order to better understand the essence of the present invention, the following pharmacological tests and clinical observation tests are used to prove the role of Liuwei Anxiao pharmaceutical composition and its preparation in the "treatment of alcoholic hepatitis", and illustrate its new application in the pharmaceutical field.

[0035] Case admission criteria

[0036] According to the diagnostic criteria of alcoholic liver disease formulated by the Fatty Liver and Alcoholic Liver Disease Group of the Liver Disease Branch of the Chinese Medical Association in October 2010:

[0037] 1) Long-term drinking history, generally more than 5 years, equivalent to alcohol content, male ≥40g / d, female ≥20g / d, or history of heavy drinking within 2 weeks (> 80g / d);

[0038] 2) The increase of aspartate aminotransferase (AST) is significantly greater than the increase of alanine aminotransferase (ALT),...

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Abstract

The invention discloses a Liuwei Anxiao pharmaceutical composition and application of a preparation thereof in preparation of a drug for treating alcoholic hepatitis. The Liuwei Anxiao pharmaceutical composition comprises six medicine ingredients, namely, Tibet inula root, rheum officinale, rhizoma kaempferiae, fumed gypsum, fructus chebulae and tronae. The clinical test shows that the Liuwei Anxiao pharmaceutical composition can protect alcoholic liver injury and can also obviously improve AST (Aspartate Transaminase), ALT (Alanine Aminotransferase), GGT (Gamma Glutamyl Transpeptidase), TBiL (Total Bilirubin) and other biochemical indexes.

Description

Technical field [0001] The invention relates to the application of a Liuwei Anxiao pharmaceutical composition and its preparation in the preparation of a medicine for treating alcoholic hepatitis, and belongs to the field of medicine. Background technique [0002] Alcoholic hepatitis is a clinical type of alcoholic liver disease. It is a group of clinicopathological syndromes caused by massive necrosis of liver cells in a short period of time. It can occur on the basis of with or without cirrhosis, mainly manifested by elevated serum ALT and AST. And serum total bilirubin was significantly increased, which may be accompanied by fever and increased peripheral blood neutrophils. [0003] The main clinical manifestation of alcoholic hepatitis is the rapid appearance of jaundice. Other symptoms and signs include fever, ascites, and proximal muscle relaxation. Patients with severe alcoholic hepatitis may develop hepatic encephalopathy. Generally, patients with alcoholic hepatitis have ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P1/16A61K33/00A61K33/06
Inventor 彭坤邵成雷单玉刚付素心王海苹
Owner JINKE TIBETAN MEDICINE QINGHAI PROV
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