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A carbon dioxide microbubble ultrasound contrast agent

A technology of carbon dioxide and contrast agent, applied in the direction of echo/ultrasonic imaging agent, etc., can solve the problem of no adverse reactions observed, and achieve the effect of uniform size, clear display, and obvious light spots

Active Publication Date: 2014-10-29
上海中山医疗科技发展有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, previous clinical trials have also shown that in the 16 patients diagnosed with carbon dioxide microbubble cardiac angiography, no adverse reactions due to angiography were observed during the diagnosis process.

Method used

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  • A carbon dioxide microbubble ultrasound contrast agent
  • A carbon dioxide microbubble ultrasound contrast agent
  • A carbon dioxide microbubble ultrasound contrast agent

Examples

Experimental program
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Effect test

Embodiment 1

[0031] A kind of carbon dioxide microbubble ultrasonic contrast agent, is made up of No. 1 gas-generating solution and No. 2 gas-generating solution, and the No. 1 gas-generating solution is a sodium bicarbonate solution ( That is conventional medicinal 5% sodium bicarbonate [PH=8.0]). The No. 2 gas production solution is a vitamin C solution with a pH of 2.0 and a concentration of 0.05 g / ml. The vitamin C solution contains 0.001g / ml sodium sulfite and 0.0001g / ml edetate disodium. The No. 1 gas-generating solution is a commercially available product. The preparation method of the No. 2 gas-generating solution is as follows: add 5 grams of vitamin C, 0.1 gram of sodium sulfite, and 0.01 gram of disodium edetate into water for injection, and set the volume to 100 milliliters. After the chemical powder is fully dissolved, it is potted and sterilized for storage.

Embodiment 2

[0033] A kind of carbon dioxide microbubble ultrasonic contrast agent, is made up of No. 1 gas-generating solution and No. 2 gas-generating solution, and the No. 1 gas-generating solution is a sodium bicarbonate solution ( That is conventional medicinal 5% sodium bicarbonate [PH=8.0]). The No. 2 gas production solution is a vitamin C solution with a pH of 2.5 and a concentration of 0.04 g / ml. The vitamin C solution contains 0.001g / ml sodium sulfite and 0.0001g / ml edetate disodium. The No. 1 gas-generating solution is a commercially available product. The preparation method of the No. 2 gas-generating solution is as follows: add 4 grams of vitamin C, 0.1 gram of sodium sulfite, and 0.01 gram of disodium edetate into water for injection, and set the volume to 100 milliliters. After the chemical powder is fully dissolved, it is potted and sterilized for storage.

Embodiment 3

[0035] A kind of carbon dioxide microbubble ultrasonic contrast agent, is made up of No. 1 gas-generating solution and No. 2 gas-generating solution, and the No. 1 gas-generating solution is a sodium bicarbonate solution ( That is conventional medicinal 5% sodium bicarbonate [PH=8.0]). The No. 2 gas production solution is a vitamin C solution with a pH of 1.8 and a concentration of 0.06 g / ml. The vitamin C solution contains 0.001g / ml sodium sulfite and 0.0001g / ml edetate disodium. The No. 1 gas-generating solution is a commercially available product. The preparation method of the No. 2 gas-generating solution is as follows: add 6 grams of vitamin C, 0.1 gram of sodium sulfite, and 0.01 gram of edetate disodium into water for injection, set the volume to 100 milliliters, shake, and make After the chemical powder is fully dissolved, it is potted and sterilized for storage.

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Abstract

The invention provides a carbon dioxide microbubble ultrasonic pericardial cavity contrast medium, which is characterized by comprising a No. 1 aerogenesis solution and a No. 2 aerogenesis solution, wherein the No. 1 aerogenesis solution is a dicarbonate solution, and the No. 2 aerogenesis solution is a vitamin C solution. According to the invention, the No. 1 aerogenesis solution and the No. 2 aerogenesis solution respectively belong to a mild base and a weak acid, and generate numberless micro carbon dioxide bubbles after mixing, generate a strong echo on ultrasound image; the use amount of the No. aerogenesis solution and the No. 2 aerogenesis solution can be controlled by an checker as required; the purpose of right heart contrast is well obtained.

Description

technical field [0001] The invention relates to a carbon dioxide microbubble ultrasonic cardiac contrast agent. Background technique [0002] Echocardiography (cardiac ultrasound) is a simple, cheap, and highly operable real-time cardiovascular imaging method. It has important clinical significance for the diagnosis and treatment of cardiovascular diseases and is a commonly used first-line examination method. Under normal circumstances, the blood in the cardiac cavity, great vessels and myocardial tissue cannot be displayed by ultrasound, and there is no echo reflection, and a large amount of diagnostic information contained in it cannot be detected. Therefore, the acoustic contrast method came into being. Contrast-enhanced ultrasound can highlight blood flow that would otherwise not be visible. [0003] Cardiac acoustic contrast agents are divided into left heart contrast agents and right heart contrast agents. These two contrast agents are generally injected through peri...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/22
Inventor 程蕾蕾舒先红沈学东
Owner 上海中山医疗科技发展有限公司
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