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Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation

A technology of scalar coupling and localized spectrum, which is applied in the field of obtaining single-pixel one-dimensional localized spectrum that eliminates scalar coupling modulation, can solve the problems of signal amplitude and phase distortion, signal quantization error, etc., and achieve the goal of removing signal amplitude and phase Distorted, well localized effect

Inactive Publication Date: 2014-03-19
XIAMEN UNIV
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Problems solved by technology

Scalar coupling modulation will cause the distortion of the signal amplitude and phase, and then cause the error of signal quantization

Method used

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  • Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation
  • Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation
  • Method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation

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Embodiment Construction

[0031] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0032] In this embodiment, a Varian Varian500MHz magnetic resonance instrument equipped with a three-dimensional gradient field is used. Sample 1 is a casing sample composed of 1mol / L threonine plus γ-aminobutyric acid solution, sample 2 is a brain model solution, and sample 3 is Actual porcine brains were loaded into NMR tubes to form samples. The pulse sequence used is a one-dimensional localized spectral pulse sequence that can eliminate scalar coupling modulation, such as figure 1 shown; and a standard fixed-point resolved spectrum sequence, such as figure 2 shown.

[0033] refer to figure 1 , for sample 1, respectively measure the 90-degree and 180-degree radio frequency pulse widths of the sample, and use the measured 90-degree hard radio frequency pulse in the x direction to drive the magnetization vector from the Z direction to the XY plane. A h...

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Abstract

The invention provides a method for obtaining single voxel one-dimensional localization spectra capable of eliminating scalar coupling modulation. A same-direction 90-degree radio-frequency pulse is added between two spin echo modules to form a hard pulse scalar coupling re-aggregation module and a soft pulse scalar coupling re-aggregation module, the interval t between the pulses in the re-aggregation modules is set according to the coupling system condition included in a sample, and when the t and scalar coupling constant J product is much smaller than 1, the scalar coupling re-aggregation modules can eliminate scalar coupling modulation effects caused by various coupling systems. The soft pulse scalar coupling re-aggregation module completes voxel selection by combining with selecting layers and destroy gradients. According to the method, by the aid of the obtained one-dimensional localization spectra, signal amplitude and phase distortions caused by scalar coupling modulation can be prevented, perfect signals are obtained, and spectrogram attribution analysis is facilitated.

Description

technical field [0001] The invention relates to a method for obtaining a single-pixel one-dimensional localized spectrum, in particular to a method for obtaining a single-pixel one-dimensional localized spectrum that eliminates scalar coupling modulation. Background technique [0002] Localized nuclear magnetic resonance spectroscopy (MRS), as a supplementary tool to magnetic resonance imaging (MRI), has important applications in the study of living tissues. MRS can selectively and non-invasively measure the chemical composition and structure in the tissue, the change of the chemical environment and the existing form of molecules in the living body. This information is a bridge between biochemical changes and disease pathology, which is beyond the reach of any previous imaging technology. acquired. Fixed-point resolution spectrum (Bottomley PA.Spatial Localization in NMR Spectroscopy in Vivo.Annals of the New York Academy of Sciences1987;508(1):333-348.) and stimulated echo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01R33/465
Inventor 林雁勤林良杰韦芝良陈忠
Owner XIAMEN UNIV
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