Application of fructan extract in preparing medicines, foods or health products for treating fatty liver

A technology of extract and fructan, which is applied in the field of application of fructan extract in the preparation of drugs, food or health products for the treatment of fatty liver, which can solve the problems of time-consuming, high cost, and inability to adapt to industrial production , to achieve the effect of reducing the number, alleviating hepatic steatosis, and significantly treating fatty liver

Inactive Publication Date: 2014-03-26
SHANGHAI ZHANGJIANG ENG RES CENT OF MODERN PREPARATION TECH OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current preparation methods for preparing fructan from Ophiopogon japonicus have defects such as time-consuming, high cost, and inability to adapt to industrial production, and cannot be mass-prepared
At the same time, in the prior art, there are few reports on the activity of fructan extracts in specific molecular weight ranges

Method used

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  • Application of fructan extract in preparing medicines, foods or health products for treating fatty liver
  • Application of fructan extract in preparing medicines, foods or health products for treating fatty liver
  • Application of fructan extract in preparing medicines, foods or health products for treating fatty liver

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 (preparation of fructan extract)

[0016] Take 20kg of dried Radix Ophiopogon japonicus (Sichuan Ophiopogon japonicus) root tuber, extract twice with 4 times the weight of 90% ethanol under reflux, discard the extract; extract twice with 10 times the amount of water, combine the water extract, and extract The solution was concentrated under reduced pressure to 1.0g / ml; the concentrated solution was added to 3 times the volume of 95% ethanol for precipitation, left to stand, and the precipitate was collected; the obtained supernatant was repeatedly precipitated by alcohol once, and the precipitate obtained by alcohol precipitation was combined twice. Freeze-drying is the fructan extract with a molecular weight in the range of 2500-8000. Get 4.62kg of fructan extract, the yield is: 15.4%. The structure was identified as fructan.

Embodiment 2

[0017] Embodiment 2 (preparation of fructan extract)

[0018] Take 30kg of dried Radix Ophiopogon japonicus (Sichuan Ophiopogon japonicus) tuber root, reflux extraction with 8 times the weight of 70% ethanol for 3 times, and discard the extract; The solution was concentrated under reduced pressure to 0.8g / ml; the concentrated solution of water extraction was precipitated by adding 5 times the volume of 80% ethanol for precipitation, left to stand, and the precipitate was collected; the obtained supernatant was repeatedly precipitated by alcohol once, and the precipitate obtained by alcohol precipitation was combined twice. Freeze-drying is the fructan extract with a molecular weight in the range of 2500-8000. Get 3.15kg of fructan extract, yield: 10.5%. The structure was identified as fructan.

Embodiment 3

[0019] Embodiment 3 (preparation of fructan extract)

[0020] Take 30kg of dried Radix Ophiopogon japonicus (Sichuan Ophiopogon japonicus) root tubers, extract once with 2 times the weight of 100% ethanol under reflux, and discard the extract; The solution was concentrated under reduced pressure to 1.2g / ml; the concentrated solution was added to 1 volume of 100% ethanol for precipitation, left to stand, and the precipitate was collected; the obtained supernatant was repeated alcohol precipitation once, and the precipitate obtained by alcohol precipitation was combined twice. Freeze-drying is the fructan extract with a molecular weight in the range of 2500-8000. Get 3.03kg of fructan extract, yield: 10.1%. The structure was identified as fructan. .

[0021] Known from embodiment 1-3, the yield of the fructan extract of embodiment 1 is the highest, therefore embodiment 1 is a preferred embodiment.

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Abstract

The invention discloses application of a fructan extract in preparing medicines, foods or health products for treating fatty liver. The molecular weight of the fructan extract is 2500-8000. The fructan extract is prepared by the following steps: extracting Sichuan ophiopogon root tuber with ethanol to remove impurities, extracting with water, carrying out ethanol fractional precipitation, and drying to obtain the fructan extract (the molecular weight is 2500-8000). The inspection on functions of the fructan extract by a diet-induced fat mouse model proves that the fructan extract has an obvious action of treating fatty liver.

Description

technical field [0001] The invention relates to a new application of a fructan extract, in particular to an application of a fructan extract in preparing medicine, food or health products for treating fatty liver. Background technique [0002] Fructan is a general term for a class of carbohydrates that are ubiquitous in nature and are mainly connected by glycosidic bonds of fructosyl fructose; each fructan molecule contains a molecule of glucose, and its molecular terminal is not reduced. sex. The structure of fructan is quite complicated according to the difference in the position of fructosyl transfer connection and the degree of polymerization among species. Because fructan basically does not decompose and is not digested and absorbed in the process of human mouth, stomach and small intestine. Therefore, it has better weight loss, blood sugar regulation, blood lipid lowering, prevention of heart and brain diseases; improvement of intestinal function, prevention of const...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/733A61P1/16A23L1/09C08B37/00A61K36/8968A23L29/30A23L33/125
Inventor 阮克锋冯怡从文娟王源林晓
Owner SHANGHAI ZHANGJIANG ENG RES CENT OF MODERN PREPARATION TECH OF TRADITIONAL CHINESE MEDICINE
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