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Pharmaceutical composition containing total saponins and total alkaloids of caulophyllum robustum

A technology of total alkaloids and leaf peony is applied in the directions of drug combinations, medical preparations containing active ingredients, antipyretics, etc., which can solve the problem of no analgesic effect, achieve easy quality control, and improve the apoptosis rate. , good anti-inflammatory and immunomodulatory effects

Inactive Publication Date: 2014-03-26
匡海学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, peony leaves also contain a large amount of saponins, including saponins A, B, C, D, E, etc. Saponins have strong anti-inflammatory effects, but do not have analgesic effects

Method used

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  • Pharmaceutical composition containing total saponins and total alkaloids of caulophyllum robustum
  • Pharmaceutical composition containing total saponins and total alkaloids of caulophyllum robustum
  • Pharmaceutical composition containing total saponins and total alkaloids of caulophyllum robustum

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Take the coarse powder of peony-like medicinal materials, heat and reflux the medicinal materials with an appropriate amount of 50% ethanol to extract the medicinal materials, cool the extract overnight and filter, concentrate the filtrate on D101 macroporous adsorption resin, rinse with water first, then rinse with 30-70% ethanol, wash It can be obtained by deconcentrating and freeze-drying. The extract was detected by HPLC-ELSD method, the analysis condition was Agilent Extend-C18, and the mobile phase was H 2 O-CH 3 CN, the aqueous phase decreased linearly from 70% to 10% within 30 minutes; ELSD parameters: drift tube temperature 105°C, carrier gas flow rate 2.7L / min; Glycoside D, tospinine, and methylcytisine were detected components, and their contents were determined by external standard method. Among them, the content of saponins B, D, and G of Vitiligosinus saponins are 1%, 9%, and 27%, respectively, the content of lonticin D is 5%, and the content of phyllosi...

Embodiment 2

[0014] Example 2 Analgesic effect experiment of composition 1 (total alkaloids: total saponins of phyllosides=1:40) Female mice qualified for pain threshold screening were divided into random groups, and after fasting for 6 hours, three groups were divided into three groups: Different doses of total extracts were administered intragastrically, one group was intragastrically administered the same amount of normal saline, one group was intragastrically administered Qutong Tablets, and the other three groups were intragastrically administered 1‰ total alkaloids, 4% total saponins, 0.5‰ total alkaloids and A mixture of 2% total saponins was administered. Measure the pain threshold of mice before administration, 0.5, 1, 2, 3 and 4h after administration, and calculate as 60s if it exceeds 60s. The experimental results are shown in Table 1.

[0015] Table 1: Effects of test articles on the hot plate analgesic test of mice

[0016]

[0017] Note: Compared with the control group ...

Embodiment 3

[0018] Example 3 Anti-inflammatory effect experiment of composition 2 (total alkaloids of phyllosides: total saponins of phyllosides=1:30)

[0019] Male rats with a body weight of 140-160 g were randomly divided into groups according to body weight, with 10 rats in each group, administered by intragastric administration. Subcutaneously inject 0.1ml of 10% fresh egg white solution into the area of ​​the right hind foot of the rat to the ankle joint to induce inflammation, measure the volume of the inflamed foot at 0.5h, 1h, 2h, 4h, and 6h after the inflammation, and calculate the volume of each Changes in volume of right hind paw of rats before and after inflammation. The experimental results are shown in Table 2.

[0020] Table 2: Effects of the test items of Paeoniae foliaceae on paw swelling caused by egg white (X±s.n=10)

[0021]

[0022] Note: Compared with the control group * P** P<0.01

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Abstract

The invention discloses a pharmaceutical composition containing total saponins and total alkaloids of caulophyllum robustum. The total saponins and total alkaloids of the caulophyllum robustum serve as active ingredients, and are in the mass ratio of (1:10)-(1:100). The total saponins and total alkaloids of the caulophyllum robustum are combined organically, thereby achieving the effects of dispelling wind, eliminating dampness, resisting inflammation and relieving pain. As proved by experiments, the composition has an inhibiting effect on anti-non-specific and specific inflammation models, and has a strong pain relieving effect. The apoptosis rate of RA (Rheumatoid Arthritis) rat synovial cells can be increased remarkably, thereby preventing joints from being further damaged, effectively treating rheumatoid arthritis and achieving good inflammation resisting and immunoregulation effects. Moreover, a synergistic effect is achieved by combining alkaloids with saponin compounds. Being different from a Chinese medicinal compound prepared on the basis that decoction pieces are combined, the composition is more definite in chemical ingredients of which over 50 percent can be qualified and quantified accurately, thereby easily performing quality control and meeting the requirements of the modern pharmaceuticals industry.

Description

technical field [0001] The invention relates to a pharmaceutical composition containing total saponins and total alkaloids of Paeoniae botanica, the pharmaceutical composition contains a certain proportion of total alkaloids and total saponins of Paeoniae paeoniae, and is mainly used for treating rheumatism and rheumatoid Diseases, and combined application at the same time has the effect of attenuating toxicity and enhancing efficacy. Background technique [0002] Years of clinical practice have shown that the combination of traditional Chinese and Western medicine has a positive effect on the prevention and treatment of rheumatism and rheumatoid diseases. Traditional Chinese medicine is effective in alleviating symptoms, improving immune function and body condition, and improving the quality of life of patients. However, most of the anti-rheumatism and rheumatoid traditional Chinese medicines in the past are composed of large compound prescriptions, which are difficult to m...

Claims

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Application Information

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IPC IPC(8): A61K36/29A61P19/02A61P29/00
Inventor 匡海学李国玉吕邵娃王秋红夏永刚
Owner 匡海学
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