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Spicy nasal spraying nanoemulsion and preparation method thereof

A nano-emulsion and spicy technology, applied in the field of medicine, can solve the problems of prolongation of Q-T interval, cognitive and motor function impairment, easy to produce adverse reactions, etc., and achieve the effects of improving sneezing and reducing swelling of turbinates.

Active Publication Date: 2014-04-02
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above drugs can only relieve the symptoms of AR, among which topical glucocorticoids are the most cost-effective and are the first-line drugs
And long-term use of these drugs is prone to adverse reactions, including sneezing, dry nose, burning sensation, tingling sensation and epistaxis, depression of the central nervous system, short-term slowing of children's growth rate, impairment of cognitive and motor functions, Prolongation of the Q-T interval, etc.

Method used

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  • Spicy nasal spraying nanoemulsion and preparation method thereof
  • Spicy nasal spraying nanoemulsion and preparation method thereof
  • Spicy nasal spraying nanoemulsion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The preparation of embodiment 1 spicy nasal nanoemulsion

[0021] 1. Extraction of volatile oil

[0022] Mix magnolia magnolia, patchouli, cocklebur, and asarum (Magnolia magnolia and cocklebur are coarsely crushed to facilitate extraction), and mix them according to the ratio of 5:3:3:1, and add appropriate amount Soak in water for 3 hours, then make up 5 times the amount of water of the total mass of medicinal materials, and finally extract the volatile oil with a volatile oil extractor for 6 hours.

[0023] 2. Inclusion of volatile oil

[0024] Put 80 g of β-cyclodextrin into 1000 mL of pure water, stir at 60°C until fully dissolved, remove insoluble matter by filtration, and obtain a clear saturated solution of β-cyclodextrin. Take 5 mL of the volatile oil described in 1, add 5 times the volume of absolute ethanol to dilute evenly, slowly drop into the clear saturated solution of β-cyclodextrin, and stir for 2 hours until the inclusion is uniform. Finally, put it...

Embodiment 2

[0028] Embodiment 2 clinical research

[0029] 1. Clinical data

[0030] 1.1 Source of cases

[0031] The case came from the outpatient clinic of the Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, and 120 children who were diagnosed with allergic rhinitis in children with lung-qi deficiency and cold syndrome were selected as the research objects.

[0032] 1.2 Case selection

[0033] 1.2.1 Diagnostic criteria

[0034] (1) Western medicine diagnostic criteria

[0035] The diagnostic criteria were formulated with reference to the "Guidelines for the Diagnosis and Treatment of Allergic Rhinitis in Children" (2010, Chongqing).

[0036] ①Symptoms

[0037] More than 2 (including 2) symptoms such as watery nasal discharge, nasal itching, nasal congestion, and sneezing occurred, and the symptoms lasted or accumulated for more than 1 hour every day. May be accompanied by ocular symptoms such as eye itching and conjunctival hyperemia. Children with seve...

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Abstract

The invention discloses a spicy nasal spraying nanoemulsion and a preparation method thereof, relating to the field of medicines. The preparation method comprises the steps of extracting volatile oil from four traditional Chinese medicinal materials including flos magnoliae, pogostemon cablin, cocklebur fruits and asarum by using a volatile oil extractor; then, carrying out inclusion on the volatile oil to obtain an inclusion complex; finally, redissolving the inclusion complex into ethylparaben-contained ultrapure water to obtain the spicy nasal spraying nanoemulsion. The emulsion can be used for effectively relieving the symptoms such as sneeze, rhinorrhea, rhinobyon, rhinocnesmus and minor symptoms of allergic rhinitis in children, and relieving inferior nasal concha swelling; moreover, no side effects are found before and after patients are treated.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a spicy nasal nanoemulsion and a preparation method thereof. Background technique [0002] Allergic rhinitis, also known as allergic rhinitis (allergic rhinitisAR), is clinically characterized by sudden onset of nasal itching, sneezing, runny nose, and nasal congestion. It belongs to the category of "nasal rhinitis" in traditional Chinese medicine. The disease state of an illness is repeated, and the course of disease is longer, and nasal polyps and bronchial asthma are its common complication, and there is no radical cure method so far. The incidence of this disease is relatively high, and it is gradually increasing, which brings huge economic pressure and mental burden to society, family and individual. At present, modern medical treatment of AR generally includes staying away from allergens, drugs, immunity and surgical treatment. Drugs used for AR treatment mainly include antihistam...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K9/107A61P11/02A61P37/08
Inventor 韩新民付廷明吴拥军尹东奇杨江韩江田云龙袁海霞刘文侠
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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