Natural pregnant mare conjugated estrogen purification and refinement method and application of nonionic nonpolar fine separation resin used by same

A combined estrogen and fine separation technology, which is applied in the purification and refining of natural pregnant horse combined estrogen and the application field of non-ionic and non-polar fine separation resin used, which can solve the problems of low yield, residue and low refining efficiency , to achieve the effect of simple steps and no peculiar smell

Inactive Publication Date: 2014-04-16
XINJIANG TEFENG PHARMA +1
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0014] The present invention provides a method for purifying and refining natural pregnant horse-conjugated estrogen and the application of the non-ionic and non-polar fine separation resin used; The polar fine separation resin is used for the purification and refining process engineering of extracting natural conjugated estrogen from pregnant horse urine; it overcomes the shortcomings of the existing technology and avoids the use of a large amount of toxic organic solvents for liquid-liquid extraction, environmental pollution and

Method used

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  • Natural pregnant mare conjugated estrogen purification and refinement method and application of nonionic nonpolar fine separation resin used by same
  • Natural pregnant mare conjugated estrogen purification and refinement method and application of nonionic nonpolar fine separation resin used by same

Examples

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Embodiment 1

[0048] Example 1, the purification method of natural pregnant horse-bound estrogen includes the first step of using non-ionic, non-polar fine separation resin to adsorb the starting liquid containing the pregnant horse-bound estrogen extract, and the second step using an eluting solvent from the loaded Elute on the non-ionic non-polar fine separation resin with bound estrogen mixture to obtain purified and refined bound estrogen mixture liquid,

[0049] Among them, the starting liquid containing the mixture of pregnant horse conjugated estrogen refers to: the solution prepared by dissolving the mixture of conjugated estrogen obtained from pregnant horse urine through solvent extraction in water or the combination obtained by passing pregnant horse urine through macroporous resin. A solution prepared by dissolving estrogen mixture in water.

Embodiment 2

[0050] Embodiment 2 differs from Embodiment 1 in that: the nonionic nonpolar fine separation resin is polystyrene divinylbenzene nonionic nonpolar fine separation resin.

Embodiment 3

[0051] Embodiment 3, the difference with the above-mentioned embodiment 2 is: the average particle diameter of polystyrene divinylbenzene non-ionic non-polar fine separation resin is 4 microns to 200 microns, and the specific surface area is 400 square meters per gram to 1000 m2 / g.

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Abstract

The invention relates to a natural pregnant mare conjugated estrogen purification and refinement method and application of a nonionic nonpolar fine separation resin used by the same. The method comprises the following steps: 1. adsorbing an initial liquid containing a pregnant mare conjugated estrogen crude extract by using a nonionic nonpolar fine separation resin; and 2. eluting the nonionic nonpolar fine separation resin carrying the conjugated estrogen mixture by using an eluting solvent to obtain the purified and refined conjugated estrogen mixture liquid. Compared with the prior art, the purity of the conjugated estrogen prepared by the method is up to 42.6-61.8%, and the total conjugated estrogen yield is 90.8-97.2%; and the conjugated estrogen has no peculiar smell and obviously lighter color (fine light yellow), which is very important for preparing the high-quality conjugated estrogen active pharmaceutical ingredient and preparation products. The method has the advantages of simple technique and high refinement efficiency, and is especially suitable for large-scale production.

Description

technical field [0001] The invention relates to the technical field of purifying and refining the crude extract of natural pregnant horse-conjugated estrogen by using a fine separation resin, and relates to a purification method for natural pregnant horse-conjugated estrogen and the application of the non-ionic and non-polar fine separation resin used therein. Background technique [0002] Conjugated estrogen drugs are mainly used in hormone replacement therapy (Hormone Replacement Therapy, HRT), to relieve any clinical symptoms of estrogen deficiency, to treat and prevent menopausal syndrome after women's physiological or artificial menopause, and to prevent and treat osteoporosis. The latest clinical research on osteoporosis, coronary heart disease and senile dementia found that early HRT can prevent coronary heart disease and senile dementia. Natural conjugated estrogens have been used for a long time for their good efficacy and tolerability. [0003] Conjugated estrogen...

Claims

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Application Information

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IPC IPC(8): A61K35/22A61P5/30A61P15/12A61P19/10A61P9/10A61P25/28
Inventor 高晓黎孔金金肖建民
Owner XINJIANG TEFENG PHARMA
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