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Medicinal composition with liver protecting function and preparation method of medicinal composition

A technology of composition and liver function, which is applied in the direction of drug combination, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of uneven active ingredient content, cumbersome production process, and complicated ingredients in soft capsules, and achieve the goal of promoting liver function. Cell repair, solve the effect of cumbersome extraction process and simple operation

Active Publication Date: 2014-04-23
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0022] The invention provides a pharmaceutical composition with hepatoprotective function and its preparation method to solve the problems of complex ingredients, cumbersome production process and uneven content of active ingredients in the produced soft capsules in the existing prescription

Method used

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  • Medicinal composition with liver protecting function and preparation method of medicinal composition

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Effect test

Embodiment 1

[0048] The preparation of embodiment 1 soft capsule of the present invention

[0049] The amount of each component has a better curative effect within the following weight ranges:

[0050] 28 parts of sea buckthorn, 32 parts of kudzu root, 22 parts of gardenia, 19 parts of nutmeg.

[0051] Composition extract of the present invention can be obtained by following preparation method:

[0052] ① Take seabuckthorn, crush it, pass through a 40-mesh sieve, and use CO 2 Supercritical extraction of effective components, extraction temperature 35°C, extraction pressure 25MPa, extraction time 3h, extraction flow rate 18kg / h, to obtain oily active ingredients;

[0053] ②Mix kudzu root, gardenia and nutmeg, crush them, pass through a 20-mesh sieve, add 8 times the volume of 50% ethanol for extraction, extract twice, each time for 4 hours, concentrate the extract, and dry to dry powder;

[0054] ③ After combining the obtained above-mentioned active ingredient extracts, dissolve them in...

Embodiment 2

[0055] Embodiment 2: the preparation of soft capsule of the present invention

[0056] The amount of each component has a better curative effect within the following weight ranges:

[0057] 33 parts of sea buckthorn, 42 parts of kudzu root, 27 parts of gardenia, 22 parts of nutmeg.

[0058] Composition extract of the present invention can be obtained by following preparation method:

[0059] ① Take seabuckthorn, crush it, pass through a 60-mesh sieve, and use CO 2 Supercritical extraction of effective components, extraction temperature 38°C, extraction pressure 33MPa, extraction time 3.5h, extraction flow rate 20kg / h, to obtain oily active ingredients;

[0060] ② Mix kudzu root, gardenia and nutmeg, crush them, pass through a 40-mesh sieve, add 10 times the volume of ethanol with a concentration of 65%, extract, extract 3 times, each time for 5 hours, concentrate the extract, and dry to dry powder;

[0061] ③ After combining the obtained above-mentioned active ingredient e...

Embodiment 3

[0062] Embodiment 3: the preparation of soft capsule of the present invention

[0063] The amount of each component has a better curative effect within the following weight ranges:

[0064] 38 parts of sea buckthorn, 52 parts of kudzu root, 32 parts of gardenia, 25 parts of nutmeg.

[0065] Composition extract of the present invention can be obtained by following preparation method:

[0066] ① Take seabuckthorn, crush it, pass through a 60-mesh sieve, and use CO 2 Supercritical extraction of effective components, extraction temperature 40°C, extraction pressure 40MPa, extraction time 4h, extraction flow rate 22kg / h, to obtain oily active ingredients;

[0067] ②Mix kudzu root, gardenia and nutmeg, crush them, pass through a 60-mesh sieve, add 12 times the volume of 80% ethanol for extraction, extract 3 times, each time for 6 hours, concentrate the extract, and dry to dry powder;

[0068] ③ After combining the obtained above-mentioned active ingredient extracts, dissolve them ...

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Abstract

The invention relates to a medicinal composition with a liver protecting function and a preparation method of the medicinal composition, and belongs to the field of traditional Chinese medicine. The medicinal composition is prepared from the following raw medicines by weight: 28 to 38 parts of sea buckthorn, 32 to 52 parts of puerarin, 22 to 32 parts of gardenia and 19 to 25 parts of nutmeg, and an optimum dosage form of the medicinal composition is a soft capsule. Dialectical theories are adopted and scientific compatibility and formula of the medicines are utilized to prepare the medicinal composition according to theories of the traditional Chinese medicine and physiological characteristics of the liver, and functional pharmacological experiments prove that a health-care product provided by the invention has good functions of protecting the liver, promoting the liver cell to be repaired, and improving the liver function and regeneration, and the medicine is safe and reliable.

Description

technical field [0001] The invention belongs to the fields of medicine, food and health products, and in particular relates to a pharmaceutical composition with hepatoprotective effect. Background technique [0002] Due to the high pressure of life and the deterioration of the living and working environment, the number of people with liver damage caused by exposure to chemical poisons (such as alcohol and other toxic substances) is also increasing. Among them, alcoholism and alcoholism are gradually increasing. Chemical liver injury is also increasing among workers in the pharmaceutical synthesis and chemical production industries. Patients with acute and chronic hepatitis caused by chemical liver damage are also increasing, seriously affecting people's physical and mental health. There are various liver-protecting drugs and health care products on the market at present. However, while the existing liver-protecting drugs and health products protect people's liver, they also...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P1/16
Inventor 金向群杨悦婧宋岐刘京硕宋伶俐
Owner JILIN UNIV
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