Derivative of nitrofuran medicament metabolites as well as high performance liquid chromatography fluorescence detection

A technology for nitrofuran and metabolites, which is applied in the field of preparation of nitrofuran drug metabolites

Inactive Publication Date: 2014-05-21
FUYANG NORMAL UNIVERSITY
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Problems solved by technology

However, its metabolites will remain in the body for a long time in

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  • Derivative of nitrofuran medicament metabolites as well as high performance liquid chromatography fluorescence detection
  • Derivative of nitrofuran medicament metabolites as well as high performance liquid chromatography fluorescence detection
  • Derivative of nitrofuran medicament metabolites as well as high performance liquid chromatography fluorescence detection

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Embodiment Construction

[0012] The preparation method step of the present invention is as follows

[0013] 1. Weigh 0.1128g of sodium methoxide, measure 0.23ml of methanol and 1.35ml of ethanolhydrazine, add them into a 50ml three-necked flask, and stir thoroughly for 20min to fully dissolve the sodium methoxide, and the flask is a colorless and transparent solution;

[0014] 2. Add 2.53ml of dimethyl carbonate, keep warm at 70°C for 1h, slowly stir and heat up to 75°C, open to reflux to distill methanol, reflux for 2h until methanol distillation is complete, and end the reaction to obtain AOZ synthesis liquid;

[0015] 3. Weigh 0.344g (20mmoL) 2-hydroxy-1-naphthaldehyde, dissolve it with 25mL ethanol, add this solution dropwise to the AOZ synthetic solution, pay attention to the speed when adding, about 3s a drop, add dropwise while stirring , the filtrate gradually became turbid, the solution was light yellow, refluxed at 70°C for 2 hours, the upper layer in the three-necked flask was a light yello...

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Abstract

The invention discloses a derivative of nitrofuran medicament metabolites as well as high performance liquid chromatography fluorescence detection. The method mainly comprises the following step that the derivative of the nitrofuran medicament metabolites is synthesized by matching sodium methylate, methyl alcohol and ethanol hydrazine according to certain dosage, and thus the liquid chromatography fluorescence detection is realized.

Description

technical field [0001] The invention relates to the preparation of a nitrofuran drug metabolite, in particular to a preparation method of a nitrofuran metabolite AOZ and the detection of AOZ by a high performance liquid chromatography fluorescence method. Background technique [0002] Nitrofurans are synthetic broad-spectrum antibacterial drugs with the basic structure of 5-nitrofuran, which are effective against most Gram-positive and Gram-negative bacteria, some fungi and protozoa. It has inhibitory effect and has been widely used in the prevention and treatment of animal infectious diseases such as poultry, livestock, aquatic products, and bees. However, the side effects of nitrofuran drugs have attracted people's attention. For example, furazolidone is very effective in treating enteritis and dysentery, and it is relatively economical. Therefore, some breeding enterprises use furazolidone as the main product for preventing animal diarrhea and cholera, and use it for a lo...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
Inventor 盛良全徐华杰杜娜娜刘昭第宋崇富陈明明胡小娟
Owner FUYANG NORMAL UNIVERSITY
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