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Electro-microneedle integrated body for in-situ cutaneous gene transfer and method of manufacturing same

A technology of integrated body and microneedle, which is applied in the direction of skin-piercing electrodes, microneedle, electrotherapy, etc., can solve the problem of difficult preparation of monolithic integrated body, and achieve the effect of improving efficiency

Active Publication Date: 2014-05-28
RAPHAS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it is difficult to fabricate a monolithic assembly that integrates dissolvable microneedles and electroporation electrodes into one structure using the conventional forming method for fabricating dissolvable microneedles, i.e., microcasting.

Method used

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  • Electro-microneedle integrated body for in-situ cutaneous gene transfer and method of manufacturing same
  • Electro-microneedle integrated body for in-situ cutaneous gene transfer and method of manufacturing same
  • Electro-microneedle integrated body for in-situ cutaneous gene transfer and method of manufacturing same

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Embodiment Construction

[0020] Hereinafter, an electronic microneedle assembly and a manufacturing method thereof according to exemplary embodiments of the present invention will be described in detail with reference to the accompanying drawings.

[0021] figure 1 A flowchart showing a method for preparing an electronic microneedle assembly according to an embodiment of the present invention, figure 2 and image 3 An approximate perspective view of the electroporation electrode is shown, and Figure 4 and Figure 5 An approximate flowchart of the microneedle formation method is shown.

[0022] see Figure 1-Figure 5 , The method (M100) for preparing an electronic microneedle assembly according to an embodiment of the present invention includes: preparing an electroporation electrode (S10), preparing a mixed composition (S20), and forming a microneedle (S30).

[0023] The preparation of the electroporation electrode (S10) is the step of preparing the electrode for electroporation. The electropo...

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Abstract

The present invention relates to an electro-microneedle integrated body in which a dissolvable microneedle and an electricity transmitting electrode are integrated with each other to concentratedly and efficiently perform cutaneous gene release and gene introduction into target cells at a region to be treated, and a method of manufacturing same. The electro-microneedle integrated body according to the present invention includes: a base part; an electricity transmitting electrode including a plurality of electrode parts protruding from the base part, the electricity transmission electrode contacting skin of the human body to apply an electric field pulse; and a microneedle including a biocompatible and biodegradable viscous material and a dielectric material, the microneedle being attached to each of the electrode parts and inserted into the skin of the human body. Thus, the microneedle may be dissolved within the skin, and then, the electricity transmitting electrode applies the electric field pulse to a position in which the microneedle is inserted.

Description

technical field [0001] The invention relates to an electronic microneedle assembly and a preparation method of the electronic microneedle assembly, in which a dissolvable microstructure and an electroporation electrode are integrated into a structure for permeation at a treatment site Skin gene delivery. Background technique [0002] The purpose of gene delivery (gene transfer, delivery) and gene therapy is to replace genes in defective cells by introducing foreign genes into the human body, or to provide special functions by introducing needed genes to treat diseases or to study therapeutic models. In particular, gene transfer and gene therapy in the skin have attracted much attention due to the skin's accessibility and ease of monitoring, as well as the presence of various intradermal immune cells therein, however, the effective infusion of foreign genes into skin target cells and their stable In the study of expression delivery technology (gene delivery system), gene pen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61K48/00A61M5/158
CPCA61K9/0009A61K9/0021A61K48/0075A61M37/0015A61M2037/0046A61M2037/0053A61N1/042A61N1/0424A61N1/0476A61N1/0502A61K48/00A61M5/158A61M37/00A61N1/327B05D5/00
Inventor 丁炯一李光郑道铉金正东
Owner RAPHAS
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