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Preparation method of ginseng-monkshood-salvia miltiorrhiza freeze-dried oral preparation

An oral preparation, the technology of Shenfudan, applied in the field of medicine, can solve the problems of slow absorption, large side effects of western medicine, inconvenient use of traditional Chinese medicine injections, etc., and achieve the effect of less impurities, high safety, and uniform and stable drug quality

Inactive Publication Date: 2014-06-18
哈药集团中药二厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a kind of Shenfu Dan in order to solve the existing problems of large side effects of western medicine commonly used in the existing market, certain restrictions of traditional Chinese medicine injection due to inconvenient use, and slow absorption of tablets and granules. Preparation method of freeze-dried oral preparation

Method used

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  • Preparation method of ginseng-monkshood-salvia miltiorrhiza freeze-dried oral preparation

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specific Embodiment approach 1

[0040] Specific embodiment one: the preparation method of a kind of Shenfudan freeze-dried oral preparation of the present embodiment is completed according to the following steps:

[0041] Step 1: Prepare red ginseng extract:

[0042] Described red ginseng extract is made by following method:

[0043]Crush 300-600 parts by weight of red ginseng medicinal materials into coarse powder, add 8-10 times the amount of ethanol with a mass percentage of 50%-70% to reflux extract three times, each time for 1.5-2 hours, filter, combine the filtrate, and recover Ethanol solution until it has no alcohol smell, then concentrate to a relative density of 1.1, centrifuge the filtrate for 30-40 minutes, take the supernatant and pass it through DM-101 macroporous resin, wash with 4-6 times the column volume of water, and then wash with 6- 8 times the column volume and mass percentage content of 50-70% ethanol for elution, collect the eluate, recover the ethanol until it has no alcohol smell, ...

specific Embodiment approach 2

[0069] Specific embodiment two: the difference between this embodiment and specific embodiment one is: the extraction method of the red ginseng extract described in step one is:

[0070] Crush 300-500 parts by weight of red ginseng medicinal materials into coarse powder, add 8-9 times the amount of ethanol with a mass percentage of 60%-70% to reflux extract three times, each time for 1.5-2 hours, filter, combine the filtrate, and recover Ethanol solution until there is no alcohol smell, concentrate to a relative density of 1.1, centrifuge for 30-35 minutes, take the supernatant and pass through DM-101 macroporous resin, wash with 4-5 times column volume of water, and then wash with 6-7 times column volume Elute with 60%-70% ethanol by mass, collect the eluate, recover the ethanol until it has no alcohol smell, then concentrate the eluate to a relative density of 1.06 to obtain the red ginseng extract. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0071] Specific embodiment three: the difference between this embodiment and specific embodiment one or two is: the extraction method of the red ginseng extract described in step one is:

[0072] Crush 300-400 parts by weight of red ginseng medicinal materials into coarse powder, add 8-9 times the amount of ethanol with a mass percentage of 65%-70% to reflux extract three times, each time for 1.5-2 hours, filter, combine the filtrate, and recover Ethanol solution until there is no alcohol smell, concentrate to a relative density of 1.1, centrifuge for 30-35 minutes, take the supernatant through DM-101 macroporous resin, wash with 4-4.5 times the column volume of water, and then wash with 6-4.5 times the column volume Elute with 60%-70% ethanol by mass, collect the eluate, recover the ethanol until it has no alcohol smell, then concentrate the eluate to a relative density of 1.06 to obtain the red ginseng extract. Others are the same as in the first or second embodiment.

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Abstract

The invention discloses a preparation method of a ginseng-monkshood-salvia miltiorrhiza freeze-dried oral preparation, and relates to a preparation method of an oral preparation, and the ginseng-monkshood-salvia miltiorrhiza freeze-dried oral preparation is used for solving the existing problems that common Western medicines in the existing market are high in side effect, traditional Chinese medicine injection is subjected to a certain restriction due to inconvenient use, and other dosage forms such as tablet and granule are slow to absorb. The preparation method comprises the following steps: I, preparing a red ginseng extracting solution; II, preparing a monkshood extracting solution; III, preparing a salvia miltiorrhiza extracting solution; IV, mixing the red ginseng extracting solution, the monkshood extracting solution and the salvia miltiorrhiza extracting solution, and freeze-drying a clear paste by virtue of a freeze-drying technology to obtain the ginseng-monkshood-salvia miltiorrhiza freeze-dried oral preparation. The novel oral freeze-dried preparation disclosed by the invention is used for treating chronic cardiac failure and is capable of meeting urgent clinical needs. The preparation preserves experience accumulation of traditional medicines to the greatest extent. The preparation method is simple in three medicine extracting processes, relatively high in extract purity, low in impurity content, high in safety, more uniform and stable in medicine quality and applicable to industrial production. The preparation method disclosed by the invention is applicable to field of preparation of oral preparation.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to a freeze-dried oral preparation for treating chronic heart failure. Background technique [0002] Cardiovascular disease is the most common disease that threatens human health. Cardiovascular disease ranks among the top three causes of death worldwide, and its incidence rate ranks first in China. In recent years, as the incidence of cardiovascular disease has increased year by year, heart failure patients have become an important part of clinical diseases. Heart failure (referred to as heart failure), also known as "myocardial failure", refers to the inability of the heart to pump out the blood supply commensurate with venous return and body tissue metabolism. It is one of the common clinical diseases and frequently-occurring diseases. With the updating of heart failure treatment guidelines in modern medicine, the innovation of treatment methods and the transformation of treatment...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/714A61K9/19A61P9/04
Inventor 凌雪宇赵鲁元栾韦伯曹明珠曲林刘文亮单钰毓井维洋李文春李殿明王英新
Owner 哈药集团中药二厂
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