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Application of tekaning (Chinese character) in preparation of mitochondrial injury protective agent

A protective agent and mitochondrial technology, which is applied in the application field of tecanin in the preparation of drugs for inhibiting mitochondrial damage, food or health products, and can solve problems such as Parkinson's disease, nerve cell apoptosis and necrosis

Inactive Publication Date: 2014-06-25
何蓉蓉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of studies have proved that if the damaged mitochondria in dopaminergic neurons cannot be cleared by autophagy in time, the mitochondrial modulus potential will release apoptosis factors and enter the cytoplasm to cause apoptosis and necrosis of dopaminergic neurons, which will lead to the occurrence of Parkinson's disease

Method used

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  • Application of tekaning (Chinese character) in preparation of mitochondrial injury protective agent
  • Application of tekaning (Chinese character) in preparation of mitochondrial injury protective agent
  • Application of tekaning (Chinese character) in preparation of mitochondrial injury protective agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation of Teacrine dripping pills: Take 5.0g of the real compound Theacrine, mix well with 60009.5g of polyethylene glycol, melt at 80°C, cool in simethicone oil, drop into pills, Obtain 100 drop pills.

Embodiment 2

[0031] Preparation of Teacrine soft capsules: take 5.0 g of the real compound Theacrine, mix well with 45.0 g of vegetable oil, and send it into a soft capsule packaging machine to obtain 100 soft capsules.

Embodiment 3

[0033] Preparation of Teacrine Tablets: Take 5.0 g of the real compound Theacrine, add starch solution, granulate, compress into tablets, and pack separately to obtain 100 tablets.

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Abstract

The invention discloses application of a compound tekaning (Chinese character) with a structure in a formula (I) in the specification in preparation of a mitochondrial injury protective agent. In addition, the invention also discloses the mitochondrial injury protective agent of which the effective component is the compound tekaning with the structure in the formula (I). The application fully proves that the compound tekaning, and drugs, drinks or health products containing effective components of the compound tekaning can be used for effectively promoting expression of mitochondrial autophagy key signal molecules, and enhancing mitochondrial autophagy to inhibit the mitochondrial injury, so as to effectively clear mitochondrial dysfunction existing in cortical neuron, especially, dopaminergic neurons of the brain of which the mitochondrial mass is relatively low. Thus, the dopaminergic neuron is protected to play the roles of relieving parkinson's disease and the like and treating a nerve disease.

Description

technical field [0001] The present invention relates to the use of a compound Theacrine, in particular to the use of Theacrine in the preparation of drugs for inhibiting mitochondrial damage, food or health products. Background technique [0002] Parkinson's disease (PD) is a common neurodegenerative disease that can impair the motor function, language and writing abilities of patients. According to epidemiological statistics, the number of patients with Parkinson's disease in the world was 4.5 million in 2005. With the aging population, the incidence rate is increasing year by year, and the number of patients will increase to 9 million by 2030. Parkinson's disease has seriously troubled the quality of life of patients and brought heavy family and social burdens. Therefore, research on the treatment of Parkinson's disease has important social significance and broad market prospects. The pathological mechanism of Parkinson's disease is related to the selective necrosis of do...

Claims

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Application Information

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IPC IPC(8): A61K31/522A61P25/16A61P25/28A61P9/10A61P25/22A61P25/24A61P25/00A23L1/29A23L33/00
Inventor 何蓉蓉李怡芳栗原博李善宾
Owner 何蓉蓉
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