A manufacturing and controlling method of a flexible micro-driver for controlling micro-nano particles includes the steps of manufacturing a patterning template of magnetic micro-nano particles,
coating the surface of a nonmagnetic substrate with polymers, making the polymers make contact with and embedded in the micro-nano particles on the surface of the patterning template to lift the patterning template and stretch the polymers into a
mushroom-shaped micro-nano column array, heating the patterning template to make the patterned magnetic micro-nano particles disengaged from a
hydrosol adhesion layer to obtain a flexible
mushroom-shaped micro-nano column array with magnetic micro-nano particles at the top end, namely, the flexible micro-driver, making to-be-controlled micro-nano particles drip onto the surface of the flexible
mushroom-shaped micro-nano column array, adjusting and controlling the position and the horizontal / vertical movement speed of a
magnet under the nonmagnetic substrate so that the translation, grabbing and
jumping of the micro-nano particles can be controlled, and adjusting and controlling the positions and rotating speeds of a pair of magnets on the nonmagnetic substrate so that the rotating of the micro-nano particles can be controlled. The flexible micro-driver is easy to manufacture and good in
controllability.