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Etoncoxib tablet and preparation method thereof

A technology of etoricoxib and former tablets, applied in the field of pharmaceutical preparations for treating arthritis and their preparation, can solve the problems of slow drug speed, slow tablet disintegration, etc., and achieves reduction of equipment and operation costs, high dissolution rate, good The effect of operability

Inactive Publication Date: 2014-08-13
朱金强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets prepared by wet granulation were slower to disintegrate and release drug into the dissolution medium at a slower rate

Method used

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  • Etoncoxib tablet and preparation method thereof
  • Etoncoxib tablet and preparation method thereof
  • Etoncoxib tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044]

[0045] Preparation method: pulverize the etoricoxib raw material with a jet mill, weigh 1000 tablets of the etoricoxib raw material of the prescribed amount, and set aside; adopt the method of increasing in equal amounts, first mix the etoricoxib raw material with the povidone of the prescribed amount Fully mix with carboxymethyl starch sodium, and then fully mix with the prescribed amount of microcrystalline cellulose, direct-pressed lactose, and magnesium stearate in turn; the mixed powder is tested for bulk density and angle of repose, and the weight of the tablet should be converted according to the content. , for tablet compression, adjust the hardness of the tablet to 2-3kg, and the difference in loading is ±5.0%.

Embodiment 2

[0047]

[0048] Preparation method: crush the raw material of etoricoxib with a jet mill, weigh 1000 tablets of the raw material of etoricoxib in the prescribed amount, and set aside; adopt the method of increasing the amount of equal amounts, first mix the raw material of etoricoxib with the prescribed amount of povidone Fully mix, and then fully mix with pregelatinized starch, sodium hydroxymethyl starch, microcrystalline cellulose, direct-pressed lactose, and magnesium stearate in sequence; Tablet weight, perform tablet compression, adjust the hardness of the tablet to 2-3kg, and the difference in filling capacity is ±5.0%.

Embodiment 3

[0050]

[0051]

[0052] Preparation method: pulverize the raw material of etoricoxib with a jet mill, weigh 1000 tablets of the raw material of etoricoxib in the prescribed quantity, and set aside; adopt the method of equal-quantity addition, first mix the raw material of etoricoxib with the carboxymethyl carboxymethyl of the prescribed quantity Starch sodium is fully mixed, and then fully mixed with pregelatinized starch, microcrystalline cellulose, direct-pressed lactose, and magnesium stearate in sequence; after the mixed powder is tested for angle of repose and bulk density, it should be converted according to the content. The weight of the tablet is pressed, and the hardness of the tablet is adjusted to 2-3 kg, and the difference in the filling amount is ±5.0%.

[0053] The dissolution curves of the above-mentioned examples were measured respectively, and the results are shown in Table 1.

[0054] Table 1 each embodiment sample stripping curve value

[0055]

...

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Abstract

The invention provides an etoncoxib tablet and a preparation method thereof. A direct powder tableting method is adopted, the production process is simple, the production period is shortened, and the equipment and running costs are reduced. The obtained etoncoxib tablet is excellent in appearance and smooth in technical process, has high operability, high product solubility and qualified content uniformity, and can reach high bioavailability in a human body to achieve a good curative effect.

Description

field of invention [0001] The invention relates to a pharmaceutical preparation for treating arthritis and a preparation method thereof, which belongs to medicine for orthopedic diseases, and in particular to an etoricoxib tablet and a preparation method thereof. Background of the invention [0002] Rheumatoid arthritis can occur at any age, mostly in 30-60 years old, 45 years old is the most common, with age, the incidence rate also increases, the incidence rate of women is significantly higher than that of men, the number of people suffering from different degrees of rheumatoid arthritis in my country at present Already close to 200 million people. According to a survey of people aged 15 and above in Shanghai, if the economic burden of disease caused by DALY losses is not included, the annual economic burden of disease caused by arthritis per capita is 74.59 yuan. The economic burden of disease caused by each major type of arthritis is: 778.63 yuan per capita for osteoarth...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/444A61K47/38A61P19/02A61P29/00
Inventor 朱金强王俊国邓念孙媛媛
Owner 朱金强
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