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A pharmaceutical composition for preventing and treating gouty arthritis and its application

A technology for gouty arthritis and a composition, applied in the field of medicine, can solve the problem of no discovery of the biological activity of gouty arthritis after molarin, and achieve the effects of alleviating inflammatory response, slowing down the swelling of the foot, and reducing the content

Active Publication Date: 2016-01-06
NANTONG FINC PHARMA CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, by retrieving domestic and foreign literature, there is no literature report that pterostilbene has the biological activity of preventing and treating gouty arthritis.

Method used

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  • A pharmaceutical composition for preventing and treating gouty arthritis and its application
  • A pharmaceutical composition for preventing and treating gouty arthritis and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Experimental research on the anti-gouty arthritis of Mo pterostilbene in Example 1

[0016] 40 clean-grade Wistar male rats, weighing 18O-200g. The rats were randomly divided into the following four groups according to the circumference of the right hind foot and ankle: normal control group, model control group, high-dose and low-dose drug groups, with 10 rats in each group. Rats in each group were intragastrically given the corresponding test substance according to the following doses:

[0017] Normal control group: intragastric administration of 5% sodium carboxymethylcellulose solution, 1mL / 100g;

[0018] Model control group: intragastric administration of 5% sodium carboxymethylcellulose solution, 1mL / 100g;

[0019] Drug high-dose group: pterostilbene after oral administration, 30mg / kg;

[0020] Low-dose drug group: after gavage, pterostilbene, 60mg / kg;

[0021] Rats were administered once a day for a total of 6 weeks, with free access to food and water during t...

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and curing gouty arthritis and functions thereof. The composition is made of active ingredients and auxiliary materials, wherein the active ingredients include homopterocarpin. The pharmaceutical composition can relieve foot swelling caused by gouty arthritis, reduces the content of inflammatory factors FGE2 and NO in swollen foot tissue, and accordingly relieves inflammatory reactions of the foot tissue.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for preventing and treating gouty arthritis and its application. Background technique [0002] Gouty arthritis is an acute inflammatory reaction caused by the deposition of sodium urate microcrystals in the tissues around the joints. Clinically, the main manifestations are repeated attacks of joint redness, swelling, heat and pain, and increased urine uric acid and blood uric acid. Over time, tophi is deposited in the articular cartilage, joint deformity, and even kidney stones. This disease belongs to the category of Arthralgia Syndrome in the traditional medicine of the motherland, commonly known as stubborn arthralgia, blood arthralgia, etc. At present, there is no specific drug for the treatment of gouty arthritis. The main clinical treatments are colchicine, allopurinol and non-steroidal anti-inflammatory drugs. The curative effect ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61P19/02A61P19/06
Inventor 高举梅
Owner NANTONG FINC PHARMA CHEM
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